Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage

Translesion synthesis (TLS) provides a highly conserved mechanism that enables DNA synthesis on a damaged template. TLS is performed by specialized DNA polymerases of which polymerase (Pol) κ is important for the cellular response to DNA damage induced by benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide...

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Bibliographic Details
Published in:	Nucleic acids research Vol. 43; no. 1; pp. 282 - 294
Main Authors:	Wit, Niek, Buoninfante, Olimpia Alessandra, van den Berk, Paul C.M., Jansen, Jacob G., Hogenbirk, Marc A., de Wind, Niels, Jacobs, Heinz
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01.01.2015
Subjects:	Animals Ataxia Telangiectasia Mutated Proteins - metabolism Cell Survival Cells, Cultured Checkpoint Kinase 1 DNA Damage DNA Replication DNA-Directed DNA Polymerase - genetics DNA-Directed DNA Polymerase - physiology Genome Integrity, Repair and Methyl Methanesulfonate - toxicity Mice, Knockout Mutation Proliferating Cell Nuclear Antigen - genetics Proliferating Cell Nuclear Antigen - metabolism Protein Kinases - metabolism S Phase Ubiquitination
ISSN:	0305-1048, 1362-4962, 1362-4962
Online Access:	Get full text
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