Dual role of proliferating cell nuclear antigen monoubiquitination in facilitating Fanconi anemia-mediated interstrand crosslink repair

Abstract The Fanconi anemia (FA) repair pathway governs repair of highly genotoxic DNA interstrand crosslinks (ICLs) and relies on translesion synthesis (TLS). TLS is facilitated by REV1 or site-specific monoubiquitination of proliferating cell nuclear antigen (PCNA) (PCNA-Ub) at lysine 164 (K164)....

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Bibliographic Details
Published in:	PNAS nexus Vol. 3; no. 7; p. pgae242
Main Authors:	Shah, Ronak, Aslam, Muhammad Assad, Spanjaard, Aldo, de Groot, Daniel, Zürcher, Lisa M, Altelaar, Maarten, Hoekman, Liesbeth, Pritchard, Colin E J, Pilzecker, Bas, van den Berk, Paul C M, Jacobs, Heinz
Format:	Journal Article
Language:	English
Published:	US Oxford University Press 01.07.2024
Subjects:	Anemia Antigens Biological, Health, and Medical Sciences Care and treatment Cell cycle Crosslinking Decision making DNA repair Embryo fibroblasts Fanconi syndrome Fanconi's anemia Genetic aspects Genotoxicity Immunoprecipitation Lysine MSH2 protein MSH6 protein Mutants Mutation Physiological aspects Proliferating cell nuclear antigen Replication Spectrometry Ubiquitination Netherlands PCNA monoubiquitination mismatch repair replication stress Fanconi anemia interstrand crosslink
ISSN:	2752-6542, 2752-6542
Online Access:	Get full text
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