Population-based screening for breast and ovarian cancer risk due to BRCA1 and BRCA2

In the Ashkenazi Jewish (AJ) population of Israel, 11% of breast cancer and 40% of ovarian cancer are due to three inherited founder mutations in the cancer predisposition genes BRCA1 and BRCA2. For carriers of these mutations, risk-reducing salpingo-oophorectomy significantly reduces morbidity and...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 111; no. 39; p. 14205
Main Authors:	Gabai-Kapara, Efrat, Lahad, Amnon, Kaufman, Bella, Friedman, Eitan, Segev, Shlomo, Renbaum, Paul, Beeri, Rachel, Gal, Moran, Grinshpun-Cohen, Julia, Djemal, Karen, Mandell, Jessica B, Lee, Ming K, Beller, Uziel, Catane, Raphael, King, Mary-Claire, Levy-Lahad, Ephrat
Format:	Journal Article
Language:	English
Published:	United States 30.09.2014
Subjects:	Adult Aged Aged, 80 and over Breast Neoplasms - epidemiology Breast Neoplasms - genetics Female Genes, BRCA1 Genes, BRCA2 Genetic Carrier Screening Genetic Predisposition to Disease Genetic Testing - methods Genetics, Population Humans Israel - epidemiology Jews - genetics Male Middle Aged Ovarian Neoplasms - epidemiology Ovarian Neoplasms - genetics Risk Factors genomics
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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