Rare versus common variants in pharmacogenetics: SLCO1B1 variation and methotrexate disposition

Methotrexate is used to treat autoimmune diseases and malignancies, including acute lymphoblastic leukemia (ALL). Inter-individual variation in clearance of methotrexate results in heterogeneous systemic exposure, clinical efficacy, and toxicity. In a genome-wide association study of children with A...

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Veröffentlicht in:	Genome research Jg. 22; H. 1; S. 1
Hauptverfasser:	Ramsey, Laura B, Bruun, Gitte H, Yang, Wenjian, Treviño, Lisa R, Vattathil, Selina, Scheet, Paul, Cheng, Cheng, Rosner, Gary L, Giacomini, Kathleen M, Fan, Yiping, Sparreboom, Alex, Mikkelsen, Torben S, Corydon, Thomas J, Pui, Ching-Hon, Evans, William E, Relling, Mary V
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.01.2012
Schlagworte:	Adolescent Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - pharmacokinetics Child Child, Preschool Clinical Trials as Topic Cohort Studies Exons Female Haplotypes Humans Infant Male Methotrexate - administration & dosage Methotrexate - pharmacokinetics Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Organic Anion Transporters - genetics Organic Anion Transporters - metabolism Pharmacogenetics - methods Polymorphism, Single Nucleotide Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Solute Carrier Organic Anion Transporter Family Member 1b1
ISSN:	1549-5469, 1549-5469
Online-Zugang:	Weitere Angaben
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