Brain-derived neurotrophic factor as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?

Introduction: Central sensitization is a form of maladaptive neuroplasticity underlying many chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash, headache, chronic pelvic pain syndrome and some forms of osteoarthritis, low back pain, epicondylitis, shoulder pain and cancer pai...

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Vydáno v:Expert opinion on therapeutic targets Ročník 19; číslo 4; s. 565 - 576
Hlavní autoři: Nijs, Jo, Meeus, Mira, Versijpt, Jan, Moens, Maarten, Bos, Inge, Knaepen, Kristel, Meeusen, Romain
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Informa UK, Ltd 01.04.2015
Informa Healthcare
Témata:
Animals
Brain-Derived Neurotrophic Factor - metabolism
Central Nervous System Sensitization - physiology
chronic pain
Chronic Pain - physiopathology
Chronic Pain - therapy
Combined Modality Therapy
descending inhibition
exercise
Humans
long-term potentiation
Molecular Targeted Therapy
Neuralgia - physiopathology
Neuralgia - therapy
Neuronal Plasticity - physiology
neuropathic
pharmacotherapy
Signal Transduction - physiology
neuropathic
exercise
chronic pain
descending inhibition
pharmacotherapy
long-term potentiation
ISSN:1472-8222, 1744-7631, 1744-7631
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Abstract Introduction: Central sensitization is a form of maladaptive neuroplasticity underlying many chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash, headache, chronic pelvic pain syndrome and some forms of osteoarthritis, low back pain, epicondylitis, shoulder pain and cancer pain. Brain-derived neurotrophic factor (BDNF) is a driving force behind neuroplasticity, and it is therefore crucial for neural maintenance and repair. However, BDNF also contributes to sensitization of pain pathways, making it an interesting novel therapeutic target.Areas covered: An overview of BDNF's sensitizing capacity at every level of the pain pathways is presented, including the peripheral nociceptors, dorsal root ganglia, spinal dorsal horn neurons, and brain descending inhibitory and facilitatory pathways. This is followed by the presentation of several potential therapeutic options, ranging from indirect influencing of BDNF levels (using exercise therapy, anti-inflammatory drugs, melatonin, repetitive transcranial magnetic stimulation) to more specific targeting of BDNF's receptors and signaling pathways (blocking the proteinase-activated receptors 2-NK-κβ signaling pathway, administration of phencyclidine for antagonizing NMDA receptors, or blockade of the adenosine A2A receptor).Expert opinion: This section focuses on combining pharmacotherapy with multimodal rehabilitation for balancing the deleterious and therapeutic effects of BNDF treatment in chronic pain patients, as well as accounting for the complex and biopsychosocial nature of chronic pain.
AbstractList Introduction: Central sensitization is a form of maladaptive neuroplasticity underlying many chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash, headache, chronic pelvic pain syndrome and some forms of osteoarthritis, low back pain, epicondylitis, shoulder pain and cancer pain. Brain-derived neurotrophic factor (BDNF) is a driving force behind neuroplasticity, and it is therefore crucial for neural maintenance and repair. However, BDNF also contributes to sensitization of pain pathways, making it an interesting novel therapeutic target. Areas covered: An overview of BDNF's sensitizing capacity at every level of the pain pathways is presented, including the peripheral nociceptors, dorsal root ganglia, spinal dorsal horn neurons, and brain descending inhibitory and facilitatory pathways. This is followed by the presentation of several potential therapeutic options, ranging from indirect influencing of BDNF levels (using exercise therapy, anti-inflammatory drugs, melatonin, repetitive transcranial magnetic stimulation) to more specific targeting of BDNF's receptors and signaling pathways (blocking the proteinase-activated receptors 2-NK-κβ signaling pathway, administration of phencyclidine for antagonizing NMDA receptors, or blockade of the adenosine A2A receptor). Expert opinion: This section focuses on combining pharmacotherapy with multimodal rehabilitation for balancing the deleterious and therapeutic effects of BNDF treatment in chronic pain patients, as well as accounting for the complex and biopsychosocial nature of chronic pain.
Central sensitization is a form of maladaptive neuroplasticity underlying many chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash, headache, chronic pelvic pain syndrome and some forms of osteoarthritis, low back pain, epicondylitis, shoulder pain and cancer pain. Brain-derived neurotrophic factor (BDNF) is a driving force behind neuroplasticity, and it is therefore crucial for neural maintenance and repair. However, BDNF also contributes to sensitization of pain pathways, making it an interesting novel therapeutic target. An overview of BDNF's sensitizing capacity at every level of the pain pathways is presented, including the peripheral nociceptors, dorsal root ganglia, spinal dorsal horn neurons, and brain descending inhibitory and facilitatory pathways. This is followed by the presentation of several potential therapeutic options, ranging from indirect influencing of BDNF levels (using exercise therapy, anti-inflammatory drugs, melatonin, repetitive transcranial magnetic stimulation) to more specific targeting of BDNF's receptors and signaling pathways (blocking the proteinase-activated receptors 2-NK-κβ signaling pathway, administration of phencyclidine for antagonizing NMDA receptors, or blockade of the adenosine A2A receptor). This section focuses on combining pharmacotherapy with multimodal rehabilitation for balancing the deleterious and therapeutic effects of BNDF treatment in chronic pain patients, as well as accounting for the complex and biopsychosocial nature of chronic pain.
Introduction: Central sensitization is a form of maladaptive neuroplasticity underlying many chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash, headache, chronic pelvic pain syndrome and some forms of osteoarthritis, low back pain, epicondylitis, shoulder pain and cancer pain. Brain-derived neurotrophic factor (BDNF) is a driving force behind neuroplasticity, and it is therefore crucial for neural maintenance and repair. However, BDNF also contributes to sensitization of pain pathways, making it an interesting novel therapeutic target.Areas covered: An overview of BDNF's sensitizing capacity at every level of the pain pathways is presented, including the peripheral nociceptors, dorsal root ganglia, spinal dorsal horn neurons, and brain descending inhibitory and facilitatory pathways. This is followed by the presentation of several potential therapeutic options, ranging from indirect influencing of BDNF levels (using exercise therapy, anti-inflammatory drugs, melatonin, repetitive transcranial magnetic stimulation) to more specific targeting of BDNF's receptors and signaling pathways (blocking the proteinase-activated receptors 2-NK-κβ signaling pathway, administration of phencyclidine for antagonizing NMDA receptors, or blockade of the adenosine A2A receptor).Expert opinion: This section focuses on combining pharmacotherapy with multimodal rehabilitation for balancing the deleterious and therapeutic effects of BNDF treatment in chronic pain patients, as well as accounting for the complex and biopsychosocial nature of chronic pain.
Central sensitization is a form of maladaptive neuroplasticity underlying many chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash, headache, chronic pelvic pain syndrome and some forms of osteoarthritis, low back pain, epicondylitis, shoulder pain and cancer pain. Brain-derived neurotrophic factor (BDNF) is a driving force behind neuroplasticity, and it is therefore crucial for neural maintenance and repair. However, BDNF also contributes to sensitization of pain pathways, making it an interesting novel therapeutic target.INTRODUCTIONCentral sensitization is a form of maladaptive neuroplasticity underlying many chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash, headache, chronic pelvic pain syndrome and some forms of osteoarthritis, low back pain, epicondylitis, shoulder pain and cancer pain. Brain-derived neurotrophic factor (BDNF) is a driving force behind neuroplasticity, and it is therefore crucial for neural maintenance and repair. However, BDNF also contributes to sensitization of pain pathways, making it an interesting novel therapeutic target.An overview of BDNF's sensitizing capacity at every level of the pain pathways is presented, including the peripheral nociceptors, dorsal root ganglia, spinal dorsal horn neurons, and brain descending inhibitory and facilitatory pathways. This is followed by the presentation of several potential therapeutic options, ranging from indirect influencing of BDNF levels (using exercise therapy, anti-inflammatory drugs, melatonin, repetitive transcranial magnetic stimulation) to more specific targeting of BDNF's receptors and signaling pathways (blocking the proteinase-activated receptors 2-NK-κβ signaling pathway, administration of phencyclidine for antagonizing NMDA receptors, or blockade of the adenosine A2A receptor).AREAS COVEREDAn overview of BDNF's sensitizing capacity at every level of the pain pathways is presented, including the peripheral nociceptors, dorsal root ganglia, spinal dorsal horn neurons, and brain descending inhibitory and facilitatory pathways. This is followed by the presentation of several potential therapeutic options, ranging from indirect influencing of BDNF levels (using exercise therapy, anti-inflammatory drugs, melatonin, repetitive transcranial magnetic stimulation) to more specific targeting of BDNF's receptors and signaling pathways (blocking the proteinase-activated receptors 2-NK-κβ signaling pathway, administration of phencyclidine for antagonizing NMDA receptors, or blockade of the adenosine A2A receptor).This section focuses on combining pharmacotherapy with multimodal rehabilitation for balancing the deleterious and therapeutic effects of BNDF treatment in chronic pain patients, as well as accounting for the complex and biopsychosocial nature of chronic pain.EXPERT OPINIONThis section focuses on combining pharmacotherapy with multimodal rehabilitation for balancing the deleterious and therapeutic effects of BNDF treatment in chronic pain patients, as well as accounting for the complex and biopsychosocial nature of chronic pain.
Author Bos, Inge
Moens, Maarten
Knaepen, Kristel
Meeusen, Romain
Nijs, Jo
Versijpt, Jan
Meeus, Mira
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  surname: Nijs
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  organization: Pain in Motion international research group
– sequence: 2
  givenname: Mira
  surname: Meeus
  fullname: Meeus, Mira
  email: Jo.Nijs@vub.ac.be, Jo.Nijs@vub.ac.be
  organization: Pain in Motion international research group
– sequence: 3
  givenname: Jan
  surname: Versijpt
  fullname: Versijpt, Jan
  email: Jo.Nijs@vub.ac.be, Jo.Nijs@vub.ac.be
  organization: University Hospital Brussels, Department of Neurology and Center for Neurosciences
– sequence: 4
  givenname: Maarten
  surname: Moens
  fullname: Moens, Maarten
  email: Jo.Nijs@vub.ac.be, Jo.Nijs@vub.ac.be
  organization: University Hospital Brussels, Department of Neurosurgery and Center for Neurosciences
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  givenname: Inge
  surname: Bos
  fullname: Bos, Inge
  email: Jo.Nijs@vub.ac.be, Jo.Nijs@vub.ac.be
  organization: Vrije Universiteit Brussel, Department of Human Physiology, Faculty of Physical Education and Physiotherapy
– sequence: 6
  givenname: Kristel
  surname: Knaepen
  fullname: Knaepen, Kristel
  email: Jo.Nijs@vub.ac.be, Jo.Nijs@vub.ac.be
  organization: Vrije Universiteit Brussel, Department of Human Physiology, Faculty of Physical Education and Physiotherapy
– sequence: 7
  givenname: Romain
  surname: Meeusen
  fullname: Meeusen, Romain
  email: Jo.Nijs@vub.ac.be, Jo.Nijs@vub.ac.be
  organization: Vrije Universiteit Brussel, Department of Human Physiology, Faculty of Physical Education and Physiotherapy
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25519921$$D View this record in MEDLINE/PubMed
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exercise
chronic pain
descending inhibition
pharmacotherapy
long-term potentiation
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Snippet Introduction: Central sensitization is a form of maladaptive neuroplasticity underlying many chronic pain disorders, including neuropathic pain, fibromyalgia,...
Central sensitization is a form of maladaptive neuroplasticity underlying many chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash,...
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SubjectTerms Animals
Brain-Derived Neurotrophic Factor - metabolism
Central Nervous System Sensitization - physiology
chronic pain
Chronic Pain - physiopathology
Chronic Pain - therapy
Combined Modality Therapy
descending inhibition
exercise
Humans
long-term potentiation
Molecular Targeted Therapy
Neuralgia - physiopathology
Neuralgia - therapy
Neuronal Plasticity - physiology
neuropathic
pharmacotherapy
Signal Transduction - physiology
Title Brain-derived neurotrophic factor as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?
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https://www.ncbi.nlm.nih.gov/pubmed/25519921
https://www.proquest.com/docview/1662637530
Volume 19
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