Brain-derived neurotrophic factor as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?

Introduction: Central sensitization is a form of maladaptive neuroplasticity underlying many chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash, headache, chronic pelvic pain syndrome and some forms of osteoarthritis, low back pain, epicondylitis, shoulder pain and cancer pai...

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Veröffentlicht in:Expert opinion on therapeutic targets Jg. 19; H. 4; S. 565 - 576
Hauptverfasser: Nijs, Jo, Meeus, Mira, Versijpt, Jan, Moens, Maarten, Bos, Inge, Knaepen, Kristel, Meeusen, Romain
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Informa UK, Ltd 01.04.2015
Informa Healthcare
Schlagworte:
Animals
Brain-Derived Neurotrophic Factor - metabolism
Central Nervous System Sensitization - physiology
chronic pain
Chronic Pain - physiopathology
Chronic Pain - therapy
Combined Modality Therapy
descending inhibition
exercise
Humans
long-term potentiation
Molecular Targeted Therapy
Neuralgia - physiopathology
Neuralgia - therapy
Neuronal Plasticity - physiology
neuropathic
pharmacotherapy
Signal Transduction - physiology
neuropathic
exercise
chronic pain
descending inhibition
pharmacotherapy
long-term potentiation
ISSN:1472-8222, 1744-7631, 1744-7631
Online-Zugang:Volltext
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Abstract Introduction: Central sensitization is a form of maladaptive neuroplasticity underlying many chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash, headache, chronic pelvic pain syndrome and some forms of osteoarthritis, low back pain, epicondylitis, shoulder pain and cancer pain. Brain-derived neurotrophic factor (BDNF) is a driving force behind neuroplasticity, and it is therefore crucial for neural maintenance and repair. However, BDNF also contributes to sensitization of pain pathways, making it an interesting novel therapeutic target.Areas covered: An overview of BDNF's sensitizing capacity at every level of the pain pathways is presented, including the peripheral nociceptors, dorsal root ganglia, spinal dorsal horn neurons, and brain descending inhibitory and facilitatory pathways. This is followed by the presentation of several potential therapeutic options, ranging from indirect influencing of BDNF levels (using exercise therapy, anti-inflammatory drugs, melatonin, repetitive transcranial magnetic stimulation) to more specific targeting of BDNF's receptors and signaling pathways (blocking the proteinase-activated receptors 2-NK-κβ signaling pathway, administration of phencyclidine for antagonizing NMDA receptors, or blockade of the adenosine A2A receptor).Expert opinion: This section focuses on combining pharmacotherapy with multimodal rehabilitation for balancing the deleterious and therapeutic effects of BNDF treatment in chronic pain patients, as well as accounting for the complex and biopsychosocial nature of chronic pain.
AbstractList Introduction: Central sensitization is a form of maladaptive neuroplasticity underlying many chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash, headache, chronic pelvic pain syndrome and some forms of osteoarthritis, low back pain, epicondylitis, shoulder pain and cancer pain. Brain-derived neurotrophic factor (BDNF) is a driving force behind neuroplasticity, and it is therefore crucial for neural maintenance and repair. However, BDNF also contributes to sensitization of pain pathways, making it an interesting novel therapeutic target. Areas covered: An overview of BDNF's sensitizing capacity at every level of the pain pathways is presented, including the peripheral nociceptors, dorsal root ganglia, spinal dorsal horn neurons, and brain descending inhibitory and facilitatory pathways. This is followed by the presentation of several potential therapeutic options, ranging from indirect influencing of BDNF levels (using exercise therapy, anti-inflammatory drugs, melatonin, repetitive transcranial magnetic stimulation) to more specific targeting of BDNF's receptors and signaling pathways (blocking the proteinase-activated receptors 2-NK-κβ signaling pathway, administration of phencyclidine for antagonizing NMDA receptors, or blockade of the adenosine A2A receptor). Expert opinion: This section focuses on combining pharmacotherapy with multimodal rehabilitation for balancing the deleterious and therapeutic effects of BNDF treatment in chronic pain patients, as well as accounting for the complex and biopsychosocial nature of chronic pain.
Introduction: Central sensitization is a form of maladaptive neuroplasticity underlying many chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash, headache, chronic pelvic pain syndrome and some forms of osteoarthritis, low back pain, epicondylitis, shoulder pain and cancer pain. Brain-derived neurotrophic factor (BDNF) is a driving force behind neuroplasticity, and it is therefore crucial for neural maintenance and repair. However, BDNF also contributes to sensitization of pain pathways, making it an interesting novel therapeutic target.Areas covered: An overview of BDNF's sensitizing capacity at every level of the pain pathways is presented, including the peripheral nociceptors, dorsal root ganglia, spinal dorsal horn neurons, and brain descending inhibitory and facilitatory pathways. This is followed by the presentation of several potential therapeutic options, ranging from indirect influencing of BDNF levels (using exercise therapy, anti-inflammatory drugs, melatonin, repetitive transcranial magnetic stimulation) to more specific targeting of BDNF's receptors and signaling pathways (blocking the proteinase-activated receptors 2-NK-κβ signaling pathway, administration of phencyclidine for antagonizing NMDA receptors, or blockade of the adenosine A2A receptor).Expert opinion: This section focuses on combining pharmacotherapy with multimodal rehabilitation for balancing the deleterious and therapeutic effects of BNDF treatment in chronic pain patients, as well as accounting for the complex and biopsychosocial nature of chronic pain.
Central sensitization is a form of maladaptive neuroplasticity underlying many chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash, headache, chronic pelvic pain syndrome and some forms of osteoarthritis, low back pain, epicondylitis, shoulder pain and cancer pain. Brain-derived neurotrophic factor (BDNF) is a driving force behind neuroplasticity, and it is therefore crucial for neural maintenance and repair. However, BDNF also contributes to sensitization of pain pathways, making it an interesting novel therapeutic target. An overview of BDNF's sensitizing capacity at every level of the pain pathways is presented, including the peripheral nociceptors, dorsal root ganglia, spinal dorsal horn neurons, and brain descending inhibitory and facilitatory pathways. This is followed by the presentation of several potential therapeutic options, ranging from indirect influencing of BDNF levels (using exercise therapy, anti-inflammatory drugs, melatonin, repetitive transcranial magnetic stimulation) to more specific targeting of BDNF's receptors and signaling pathways (blocking the proteinase-activated receptors 2-NK-κβ signaling pathway, administration of phencyclidine for antagonizing NMDA receptors, or blockade of the adenosine A2A receptor). This section focuses on combining pharmacotherapy with multimodal rehabilitation for balancing the deleterious and therapeutic effects of BNDF treatment in chronic pain patients, as well as accounting for the complex and biopsychosocial nature of chronic pain.
Central sensitization is a form of maladaptive neuroplasticity underlying many chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash, headache, chronic pelvic pain syndrome and some forms of osteoarthritis, low back pain, epicondylitis, shoulder pain and cancer pain. Brain-derived neurotrophic factor (BDNF) is a driving force behind neuroplasticity, and it is therefore crucial for neural maintenance and repair. However, BDNF also contributes to sensitization of pain pathways, making it an interesting novel therapeutic target.INTRODUCTIONCentral sensitization is a form of maladaptive neuroplasticity underlying many chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash, headache, chronic pelvic pain syndrome and some forms of osteoarthritis, low back pain, epicondylitis, shoulder pain and cancer pain. Brain-derived neurotrophic factor (BDNF) is a driving force behind neuroplasticity, and it is therefore crucial for neural maintenance and repair. However, BDNF also contributes to sensitization of pain pathways, making it an interesting novel therapeutic target.An overview of BDNF's sensitizing capacity at every level of the pain pathways is presented, including the peripheral nociceptors, dorsal root ganglia, spinal dorsal horn neurons, and brain descending inhibitory and facilitatory pathways. This is followed by the presentation of several potential therapeutic options, ranging from indirect influencing of BDNF levels (using exercise therapy, anti-inflammatory drugs, melatonin, repetitive transcranial magnetic stimulation) to more specific targeting of BDNF's receptors and signaling pathways (blocking the proteinase-activated receptors 2-NK-κβ signaling pathway, administration of phencyclidine for antagonizing NMDA receptors, or blockade of the adenosine A2A receptor).AREAS COVEREDAn overview of BDNF's sensitizing capacity at every level of the pain pathways is presented, including the peripheral nociceptors, dorsal root ganglia, spinal dorsal horn neurons, and brain descending inhibitory and facilitatory pathways. This is followed by the presentation of several potential therapeutic options, ranging from indirect influencing of BDNF levels (using exercise therapy, anti-inflammatory drugs, melatonin, repetitive transcranial magnetic stimulation) to more specific targeting of BDNF's receptors and signaling pathways (blocking the proteinase-activated receptors 2-NK-κβ signaling pathway, administration of phencyclidine for antagonizing NMDA receptors, or blockade of the adenosine A2A receptor).This section focuses on combining pharmacotherapy with multimodal rehabilitation for balancing the deleterious and therapeutic effects of BNDF treatment in chronic pain patients, as well as accounting for the complex and biopsychosocial nature of chronic pain.EXPERT OPINIONThis section focuses on combining pharmacotherapy with multimodal rehabilitation for balancing the deleterious and therapeutic effects of BNDF treatment in chronic pain patients, as well as accounting for the complex and biopsychosocial nature of chronic pain.
Author Bos, Inge
Moens, Maarten
Knaepen, Kristel
Meeusen, Romain
Nijs, Jo
Versijpt, Jan
Meeus, Mira
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  surname: Meeus
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  organization: Pain in Motion international research group
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  surname: Versijpt
  fullname: Versijpt, Jan
  email: Jo.Nijs@vub.ac.be, Jo.Nijs@vub.ac.be
  organization: University Hospital Brussels, Department of Neurology and Center for Neurosciences
– sequence: 4
  givenname: Maarten
  surname: Moens
  fullname: Moens, Maarten
  email: Jo.Nijs@vub.ac.be, Jo.Nijs@vub.ac.be
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  organization: Vrije Universiteit Brussel, Department of Human Physiology, Faculty of Physical Education and Physiotherapy
– sequence: 6
  givenname: Kristel
  surname: Knaepen
  fullname: Knaepen, Kristel
  email: Jo.Nijs@vub.ac.be, Jo.Nijs@vub.ac.be
  organization: Vrije Universiteit Brussel, Department of Human Physiology, Faculty of Physical Education and Physiotherapy
– sequence: 7
  givenname: Romain
  surname: Meeusen
  fullname: Meeusen, Romain
  email: Jo.Nijs@vub.ac.be, Jo.Nijs@vub.ac.be
  organization: Vrije Universiteit Brussel, Department of Human Physiology, Faculty of Physical Education and Physiotherapy
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25519921$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1186/1744-8069-10-28
10.1111/j.1749-6632.2002.tb04251.x
10.1007/s00281-011-0289-1
10.1016/j.bbi.2010.09.025
10.1007/s11357-014-9704-6
10.1016/j.bbi.2010.02.009
10.1016/S0304-3959(02)00053-2
10.1097/AJP.0b013e3181a68a040
10.1111/j.1600-0838.2011.01375.x
10.1016/j.pain.2010.09.030
10.1007/s11926-005-0021-z
10.36076/ppj.2012/15/ES205
10.1523/JNEUROSCI.5679-03.2004
10.1002/j.1532-2149.2014.499.x
10.1016/j.bbr.2014.07.001
10.1186/1744-8069-10-46
10.1097/AJP.0b013e31826f9a71
10.36076/ppj.2013/16/291
10.1016/j.clinph.2014.05.021
10.1111/head.12081
10.1016/j.expneurol.2010.01.003
10.1016/j.jaci.2005.11.049
10.1007/s10194-008-0061-7
10.1155/2010/487279
10.1016/j.archger.2012.06.003
10.1016/j.jpain.2014.05.001
10.1016/j.brainresbull.2011.08.008
10.1152/ajpregu.00525.2009
10.1016/j.pain.2013.02.025
10.2147/JPR.S63527
10.1016/S0140-6736(14)60130-6
10.1016/j.apmr.2013.03.029
10.1186/1471-2474-15-227
10.1155/2013/429815
10.2165/00007256-200029020-00002
10.1016/S1474-4422(05)70099-5
10.1016/j.neures.2005.06.008
10.1097/ACO.0b013e32833c348b
10.1097/AJP.0b013e31823dd333
10.2165/11534530-000000000-00000
10.1093/geronb/gbu096
10.1586/ern.12.41
10.3389/fncir.2014.00062
10.1523/JNEUROSCI.3686-05.2006
10.1152/jn.00116.2013
10.1016/j.biopsycho.2011.02.002
10.1523/JNEUROSCI.0846-13.2013
10.1016/j.pain.2010.06.021
10.1016/j.pneurobio.2008.04.004
10.1016/S0304-3959(00)00245-1
10.1016/j.neuroscience.2014.05.044
10.1097/ALN.0000000000000220
10.1016/j.math.2009.12.001
10.1016/j.pain.2008.05.018
10.1038/nature04223
10.1523/JNEUROSCI.2152-13.2014
10.1007/s00296-013-2786-0
10.1002/syn.21735
10.1016/S0304-3959(02)00264-6
10.1186/1744-8069-9-49
10.2522/ptj.20110290
10.1016/j.pain.2011.03.030
10.1111/j.1365-2362.2011.02575.x
10.1113/jphysiol.2006.121111
10.2522/ptj.20120253
10.1371/journal.pone.0070921
10.1038/sj.gt.3301814
10.1074/jbc.M114.580381
10.1016/j.jneuroim.2004.06.009
10.1111/j.1365-2796.2010.02228.x
10.1016/j.neuint.2014.06.004
10.1124/mol.113.086496
10.1007/978-3-642-45106-5_9
10.1016/j.pain.2009.10.032
10.1192/bjp.bp.111.107037
10.1038/nrn3379
10.1007/s10067-012-2085-2
10.1111/j.1525-1403.2012.00527.x
10.1523/JNEUROSCI.0256-08.2008
10.1186/ar2743
10.1016/S0301-0082(02)00009-6
10.1002/j.1532-2149.2012.00193.x
10.1007/s11916-005-0021-8
10.1016/j.semarthrit.2014.01.001
10.1002/jnr.23254
10.1016/j.ejpain.2008.02.002
10.1016/j.jpsychires.2006.02.007
10.1002/dneu.20605
10.1016/j.expneurol.2012.01.021
10.1016/j.apmr.2012.06.026
10.1016/j.pharmthera.2013.01.004
10.1371/journal.pone.0051149
10.1007/s00018-008-8428-0
10.2340/16501977-0595
10.1111/j.1468-2982.2009.01914.x
10.1016/S1016-8478(23)10716-3
10.1111/j.1471-4159.2005.03045.x
10.1097/BRS.0b013e3182387fb4
10.1016/j.jpain.2011.11.006
10.1016/j.pain.2014.01.010
10.1016/j.pain.2013.05.040
10.1046/j.1460-9568.2003.02848.x
10.1016/j.semarthrit.2011.08.001
10.1007/s10067-008-0910-4
10.1682/JRRD.2004.06.0065
10.1007/s004010000268
10.1016/j.jbspin.2011.03.019
10.36076/ppj.2014/17/447
10.1093/brain/awt334
10.4061/2011/650685
10.1097/00001756-200109170-00041
10.1016/j.bbr.2007.12.022
10.1016/j.jpain.2012.07.005
10.1016/j.neuropharm.2014.04.006
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descending inhibition
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long-term potentiation
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References Merighi A (CIT0062) 2008; 85
CIT0074
Lavertu G (CIT0049) 2014; 137
Guo W (CIT0068) 2006; 26
Seifert F (CIT0026) 2009; 66
McCarthy KF (CIT0045) 2013; 16
Nijs J (CIT0076) 2014
Zhou LJ (CIT0053) 2010; 148
CIT0070
Liu S (CIT0125) 2013
Brewer KL (CIT0072) 2014; 8
Perrotta A (CIT0009) 2010; 30
Pecina M (CIT0073) 2014; 34
Terkelsen AJ (CIT0018) 2014; 120
Nockher WA (CIT0031) 2006; 117
Smith JP (CIT0084) 2014; 8
Cejas PJ (CIT0059) 2000; 86
Van Houdenhove B (CIT0091) 2005; 7
Schwertner A (CIT0117) 2013; 154
Hoffman MD (CIT0104) 2005; 42
Staud R (CIT0021) 2008; 12
Simao AP (CIT0038) 2014; 34
Murakami S (CIT0094) 2005; 53
Cheng CF (CIT0131) 2014; 155
van Wilgen CP (CIT0013) 2013; 23
Kras JV (CIT0044) 2013; 91
Nijs J (CIT0011) 2012; 42
Simons LE (CIT0082) 2012; 25
Lever I (CIT0061) 2003; 18
Schwedt TJ (CIT0080) 2013; 53
Herbert J (CIT0092) 2012; 201
Novkovic T (CIT0036) 2014
Meeus M (CIT0105) 2010; 42
CIT0002
CIT0126
Eaton MJ (CIT0060) 2002; 9
Kuo HK (CIT0086) 2005; 4
Fernandez-Carnero J (CIT0015) 2009; 25
CIT0008
Jiang Y (CIT0033) 2010; 2010
CIT0093
Nijs J (CIT0098) 2014; 384
Nijs J (CIT0103) 2012; 15
Cruz Duarte P (CIT0055) 2012; 234
Khasar SG (CIT0089) 2008; 28
Forsgren S (CIT0111) 2011; 2011
Katanuma Y (CIT0124) 2014; 68
Daenen L (CIT0064) 2013; 32
CIT0099
Ferrini F (CIT0051) 2013; 2013
Coelho FG (CIT0115) 2013; 56
Zhuo M (CIT0028) 2007; 23
Kim JY (CIT0079) 2013; 154
Teasell RW (CIT0101) 2010; 15
Pillastrini P (CIT0100) 2012; 79
McLean SA (CIT0090) 2011; 36
Li Y (CIT0047) 2014; 75
Karlsson H (CIT0087) 2010; 24
Allen SJ (CIT0129) 2013; 138
Wall B (CIT0001) 1994
Cagnie B (CIT0027) 2014; 44
Bao Y (CIT0032) 2014; 10
Merighi A (CIT0054) 2008; 68
Lefaucheur JP (CIT0120) 2014; 125
Diniz BS (CIT0035) 2014; 69
Dall’Agnol L (CIT0123) 2014; 15
Nijs J (CIT0017) 2014; 17
Coombes BK (CIT0014) 2012; 28
Zhang Z (CIT0067) 2013; 84
Takeda M (CIT0040) 2013; 9
Hadjikhani N (CIT0078) 2013; 29
Paul TM (CIT0004) 2012; 93
Smith PA (CIT0030) 2014; 283
Grimsholm O (CIT0041) 2008; 27
Lefaucheur JP (CIT0119) 2001; 12
Rothmeier AS (CIT0128) 2012; 34
Staud R (CIT0063) 2012; 12
Barrientos RM (CIT0085) 2004; 155
Amadesi S (CIT0127) 2004; 24
Zanette SA (CIT0043) 2014; 10
Forti LN (CIT0116) 2014; 36
Geng SJ (CIT0048) 2010; 222
CIT0037
Kaya S (CIT0118) 2013; 16
Price DD (CIT0010) 2002; 99
Li Z (CIT0077) 2013; 8
Nijs J (CIT0020) 2010; 15
Seifert T (CIT0112) 2010; 298
Van Oosterwijck J (CIT0005) 2013; 17
Suarez-Roca H (CIT0029) 2008; 189
Tak LM (CIT0097) 2011; 87
Laske C (CIT0042) 2007; 41
Lewis GN (CIT0065) 2012; 13
Meeus M (CIT0107) 2014
Raphael KG (CIT0025) 2009; 23
Ferrer I (CIT0034) 2001; 101
Meyer RA (CIT0003) 1995
Van Oosterwijck J (CIT0110) 2010; 268
Meeus M (CIT0023) 2008; 139
Lapirot O (CIT0071) 2011; 152
Van Oosterwijck J (CIT0109) 2012; 13
Lluch E (CIT0016) 2014; 18
Lluch Girbes E (CIT0007) 2013; 93
Filatova E (CIT0024) 2008; 9
Pereira DS (CIT0114) 2013; 94
Constandil L (CIT0056) 2011; 86
Lannersten L (CIT0106) 2010; 151
Kattoor J (CIT0081) 2013; 8
Hill KT (CIT0083) 2014; 272
Generaal E (CIT0095) 2014; 15
Chen JJ (CIT0130) 2014; 24
Tomotsuka N (CIT0046) 2014; 7
Wu J (CIT0088) 2013; 33
CIT0058
Roussel NA (CIT0006) 2013; 29
CIT0057
Lamy JC (CIT0122) 2013; 110
Koltyn KF (CIT0108) 2000; 29
Tao W (CIT0039) 2014; 289
Lu B (CIT0075) 2014; 220
Gomes WF (CIT0113) 2014; 34
Tao W (CIT0069) 2014; 289
O’Connell NE (CIT0121) 2014; 4
Schlereth T (CIT0019) 2014
McNair PJ (CIT0102) 2009; 11
Le Bars D (CIT0066) 1990; 36
Coull JA (CIT0050) 2005; 438
Yarnitsky D (CIT0022) 2010; 23
Zhou LJ (CIT0052) 2011; 25
Riedel W (CIT0096) 2002; 966
Meeus M (CIT0012) 2012; 41
References_xml – volume: 10
  start-page: 28
  year: 2014
  ident: CIT0032
  publication-title: Mol Pain
  doi: 10.1186/1744-8069-10-28
– volume: 966
  start-page: 483
  year: 2002
  ident: CIT0096
  publication-title: Ann N Y Acad Sci
  doi: 10.1111/j.1749-6632.2002.tb04251.x
– volume: 34
  start-page: 133
  issue: 1
  year: 2012
  ident: CIT0128
  publication-title: Semin Immunopathol
  doi: 10.1007/s00281-011-0289-1
– volume: 25
  start-page: 322
  issue: 2
  year: 2011
  ident: CIT0052
  publication-title: Brain Behav Immun
  doi: 10.1016/j.bbi.2010.09.025
– volume: 36
  start-page: 9704
  issue: 5
  year: 2014
  ident: CIT0116
  publication-title: Age (Dordr)
  doi: 10.1007/s11357-014-9704-6
– volume: 24
  start-page: 868
  issue: 6
  year: 2010
  ident: CIT0087
  publication-title: Brain Behav Immun
  doi: 10.1016/j.bbi.2010.02.009
– volume: 99
  start-page: 49
  issue: 1
  year: 2002
  ident: CIT0010
  publication-title: Pain
  doi: 10.1016/S0304-3959(02)00053-2
– volume: 25
  start-page: 555
  issue: 7
  year: 2009
  ident: CIT0015
  publication-title: Clin J Pain
  doi: 10.1097/AJP.0b013e3181a68a040
– volume: 23
  start-page: 149
  year: 2013
  ident: CIT0013
  publication-title: Scand J Med Sci Sports
  doi: 10.1111/j.1600-0838.2011.01375.x
– ident: CIT0002
  doi: 10.1016/j.pain.2010.09.030
– volume: 7
  start-page: 365
  issue: 5
  year: 2005
  ident: CIT0091
  publication-title: Curr Rheumatol Rep
  doi: 10.1007/s11926-005-0021-z
– volume: 15
  start-page: ES205
  issue: 3
  year: 2012
  ident: CIT0103
  publication-title: Pain Physician
  doi: 10.36076/ppj.2012/15/ES205
– volume: 24
  start-page: 4300
  issue: 18
  year: 2004
  ident: CIT0127
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.5679-03.2004
– volume: 18
  start-page: 1367
  year: 2014
  ident: CIT0016
  publication-title: Eur J Pain
  doi: 10.1002/j.1532-2149.2014.499.x
– volume: 272
  start-page: 175
  year: 2014
  ident: CIT0083
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2014.07.001
– year: 2014
  ident: CIT0107
  publication-title: Pain Pract
– volume: 10
  start-page: 46
  year: 2014
  ident: CIT0043
  publication-title: Mol Pain
  doi: 10.1186/1744-8069-10-46
– volume: 29
  start-page: 625
  issue: 7
  year: 2013
  ident: CIT0006
  publication-title: Clin J Pain
  doi: 10.1097/AJP.0b013e31826f9a71
– volume: 16
  start-page: 291
  issue: 4
  year: 2013
  ident: CIT0118
  publication-title: Pain Physician
  doi: 10.36076/ppj.2013/16/291
– volume: 125
  start-page: 2150
  issue: 11
  year: 2014
  ident: CIT0120
  publication-title: Clin Neurophysiol
  doi: 10.1016/j.clinph.2014.05.021
– volume: 53
  start-page: 737
  issue: 5
  year: 2013
  ident: CIT0080
  publication-title: Headache
  doi: 10.1111/head.12081
– year: 2014
  ident: CIT0036
  publication-title: Hippocampus
– volume: 222
  start-page: 256
  issue: 2
  year: 2010
  ident: CIT0048
  publication-title: Exp Neurol
  doi: 10.1016/j.expneurol.2010.01.003
– volume: 117
  start-page: 583
  issue: 3
  year: 2006
  ident: CIT0031
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2005.11.049
– volume: 9
  start-page: 295
  issue: 5
  year: 2008
  ident: CIT0024
  publication-title: J Headache Pain
  doi: 10.1007/s10194-008-0061-7
– volume: 15
  start-page: 313
  issue: 5
  year: 2010
  ident: CIT0101
  publication-title: Pain Res Manag
  doi: 10.1155/2010/487279
– volume: 56
  start-page: 10
  issue: 1
  year: 2013
  ident: CIT0115
  publication-title: Arch Gerontol Geriatr
  doi: 10.1016/j.archger.2012.06.003
– volume: 15
  start-page: 845
  issue: 8
  year: 2014
  ident: CIT0123
  publication-title: J Pain
  doi: 10.1016/j.jpain.2014.05.001
– volume: 86
  start-page: 454
  issue: 5
  year: 2011
  ident: CIT0056
  publication-title: Brain Res Bull
  doi: 10.1016/j.brainresbull.2011.08.008
– volume: 298
  start-page: R372
  issue: 2
  year: 2010
  ident: CIT0112
  publication-title: Am J Physiol Regul Integr Comp Physiol
  doi: 10.1152/ajpregu.00525.2009
– volume: 154
  start-page: 874
  issue: 6
  year: 2013
  ident: CIT0117
  publication-title: Pain
  doi: 10.1016/j.pain.2013.02.025
– volume: 7
  start-page: 415
  year: 2014
  ident: CIT0046
  publication-title: J Pain Res
  doi: 10.2147/JPR.S63527
– volume: 384
  start-page: 109
  issue: 9938
  year: 2014
  ident: CIT0098
  publication-title: Lancet
  doi: 10.1016/S0140-6736(14)60130-6
– volume: 94
  start-page: 1443
  issue: 8
  year: 2013
  ident: CIT0114
  publication-title: Arch Phys Med Rehabil
  doi: 10.1016/j.apmr.2013.03.029
– volume: 15
  start-page: 227
  year: 2014
  ident: CIT0095
  publication-title: BMC Musculoskelet Disord
  doi: 10.1186/1471-2474-15-227
– volume: 2013
  start-page: 429815
  year: 2013
  ident: CIT0051
  publication-title: Neural Plast
  doi: 10.1155/2013/429815
– volume: 8
  start-page: 121
  year: 2014
  ident: CIT0084
  publication-title: Front Behav Neurosci
– volume: 29
  start-page: 85
  issue: 2
  year: 2000
  ident: CIT0108
  publication-title: Sports Med
  doi: 10.2165/00007256-200029020-00002
– volume: 4
  start-page: 371
  issue: 6
  year: 2005
  ident: CIT0086
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(05)70099-5
– volume: 53
  start-page: 129
  issue: 2
  year: 2005
  ident: CIT0094
  publication-title: Neurosci Res
  doi: 10.1016/j.neures.2005.06.008
– volume: 23
  start-page: 611
  issue: 5
  year: 2010
  ident: CIT0022
  publication-title: Curr Opin Anaesthesiol
  doi: 10.1097/ACO.0b013e32833c348b
– volume: 4
  start-page: Cd008208
  year: 2014
  ident: CIT0121
  publication-title: Cochrane Database Syst Rev
– volume: 28
  start-page: 595
  issue: 7
  year: 2012
  ident: CIT0014
  publication-title: Clin J Pain
  doi: 10.1097/AJP.0b013e31823dd333
– ident: CIT0093
  doi: 10.2165/11534530-000000000-00000
– volume: 69
  start-page: 845
  issue: 6
  year: 2014
  ident: CIT0035
  publication-title: J Gerontol B Psychol Sci Soc Sci
  doi: 10.1093/geronb/gbu096
– volume: 12
  start-page: 577
  issue: 5
  year: 2012
  ident: CIT0063
  publication-title: Expert Rev Neurother
  doi: 10.1586/ern.12.41
– volume: 8
  start-page: 62
  year: 2014
  ident: CIT0072
  publication-title: Front Neural Circuits
  doi: 10.3389/fncir.2014.00062
– year: 2014
  ident: CIT0076
  publication-title: Man Ther
– volume: 26
  start-page: 126
  issue: 1
  year: 2006
  ident: CIT0068
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.3686-05.2006
– volume: 110
  start-page: 109
  issue: 1
  year: 2013
  ident: CIT0122
  publication-title: J Neurophysiol
  doi: 10.1152/jn.00116.2013
– volume: 87
  start-page: 183
  issue: 2
  year: 2011
  ident: CIT0097
  publication-title: Biol Psychol
  doi: 10.1016/j.biopsycho.2011.02.002
– volume: 33
  start-page: 12447
  issue: 30
  year: 2013
  ident: CIT0088
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0846-13.2013
– volume: 25
  start-page: 22199
  issue: 10
  year: 2012
  ident: CIT0082
  publication-title: Hum Brain Mapp
– volume: 151
  start-page: 77
  issue: 1
  year: 2010
  ident: CIT0106
  publication-title: Pain
  doi: 10.1016/j.pain.2010.06.021
– volume: 85
  start-page: 297
  issue: 3
  year: 2008
  ident: CIT0062
  publication-title: Prog Neurobiol
  doi: 10.1016/j.pneurobio.2008.04.004
– volume: 86
  start-page: 195
  issue: 1
  year: 2000
  ident: CIT0059
  publication-title: Pain
  doi: 10.1016/S0304-3959(00)00245-1
– volume: 283
  start-page: 107
  year: 2014
  ident: CIT0030
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2014.05.044
– volume: 120
  start-page: 1225
  issue: 5
  year: 2014
  ident: CIT0018
  publication-title: Anesthesiology
  doi: 10.1097/ALN.0000000000000220
– volume: 15
  start-page: 135
  issue: 2
  year: 2010
  ident: CIT0020
  publication-title: Man Ther
  doi: 10.1016/j.math.2009.12.001
– volume: 139
  start-page: 439
  issue: 2
  year: 2008
  ident: CIT0023
  publication-title: Pain
  doi: 10.1016/j.pain.2008.05.018
– volume: 438
  start-page: 1017
  issue: 7070
  year: 2005
  ident: CIT0050
  publication-title: Nature
  doi: 10.1038/nature04223
– volume: 34
  start-page: 5874
  issue: 17
  year: 2014
  ident: CIT0073
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2152-13.2014
– volume: 29
  start-page: 29
  year: 2013
  ident: CIT0078
  publication-title: Cephalalgia
– volume: 34
  start-page: 841
  issue: 6
  year: 2014
  ident: CIT0113
  publication-title: Rheumatol Int
  doi: 10.1007/s00296-013-2786-0
– volume: 68
  start-page: 257
  issue: 6
  year: 2014
  ident: CIT0124
  publication-title: Synapse
  doi: 10.1002/syn.21735
– ident: CIT0057
  doi: 10.1016/S0304-3959(02)00264-6
– volume: 9
  start-page: 49
  year: 2013
  ident: CIT0040
  publication-title: Mol Pain
  doi: 10.1186/1744-8069-9-49
– ident: CIT0099
  doi: 10.2522/ptj.20110290
– volume: 152
  start-page: 1821
  issue: 8
  year: 2011
  ident: CIT0071
  publication-title: Pain
  doi: 10.1016/j.pain.2011.03.030
– volume: 42
  start-page: 203
  issue: 2
  year: 2012
  ident: CIT0011
  publication-title: Eur J Clin Invest
  doi: 10.1111/j.1365-2362.2011.02575.x
– ident: CIT0126
  doi: 10.1113/jphysiol.2006.121111
– volume: 93
  start-page: 842
  issue: 6
  year: 2013
  ident: CIT0007
  publication-title: Phys Ther
  doi: 10.2522/ptj.20120253
– start-page: 13
  volume-title: Textbook of pain
  year: 1995
  ident: CIT0003
– volume: 8
  start-page: e70921
  issue: 8
  year: 2013
  ident: CIT0077
  publication-title: PLoS
  doi: 10.1371/journal.pone.0070921
– volume: 9
  start-page: 1387
  issue: 20
  year: 2002
  ident: CIT0060
  publication-title: Gene Ther
  doi: 10.1038/sj.gt.3301814
– volume: 289
  start-page: 22196
  issue: 32
  year: 2014
  ident: CIT0069
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M114.580381
– volume: 155
  start-page: 119
  issue: 1
  year: 2004
  ident: CIT0085
  publication-title: J Neuroimmunol
  doi: 10.1016/j.jneuroim.2004.06.009
– volume: 268
  start-page: 265
  issue: 3
  year: 2010
  ident: CIT0110
  publication-title: J Intern Med
  doi: 10.1111/j.1365-2796.2010.02228.x
– volume: 36
  start-page: 329
  issue: 6
  year: 1990
  ident: CIT0066
  publication-title: Neurochirurgie
– volume: 75
  start-page: 96
  year: 2014
  ident: CIT0047
  publication-title: Neurochem Int
  doi: 10.1016/j.neuint.2014.06.004
– volume: 84
  start-page: 511
  issue: 4
  year: 2013
  ident: CIT0067
  publication-title: Mol Pharmacol
  doi: 10.1124/mol.113.086496
– volume: 220
  start-page: 223
  year: 2014
  ident: CIT0075
  publication-title: Handb Exp Pharmacol
  doi: 10.1007/978-3-642-45106-5_9
– volume: 148
  start-page: 148
  issue: 1
  year: 2010
  ident: CIT0053
  publication-title: Pain
  doi: 10.1016/j.pain.2009.10.032
– volume: 201
  start-page: 313
  issue: 4
  year: 2012
  ident: CIT0092
  publication-title: Br J Psychiatry
  doi: 10.1192/bjp.bp.111.107037
– ident: CIT0037
  doi: 10.1038/nrn3379
– volume: 32
  start-page: 23
  issue: 1
  year: 2013
  ident: CIT0064
  publication-title: Clin Rheumatol
  doi: 10.1007/s10067-012-2085-2
– volume: 16
  start-page: 519
  issue: 6
  year: 2013
  ident: CIT0045
  publication-title: Neuromodulation
  doi: 10.1111/j.1525-1403.2012.00527.x
– volume: 28
  start-page: 5721
  issue: 22
  year: 2008
  ident: CIT0089
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0256-08.2008
– volume: 11
  start-page: R98
  issue: 3
  year: 2009
  ident: CIT0102
  publication-title: Arthritis Res Ther
  doi: 10.1186/ar2743
– ident: CIT0070
  doi: 10.1016/S0301-0082(02)00009-6
– volume: 17
  start-page: 299
  issue: 3
  year: 2013
  ident: CIT0005
  publication-title: Eur J Pain
  doi: 10.1002/j.1532-2149.2012.00193.x
– ident: CIT0008
  doi: 10.1007/s11916-005-0021-8
– volume: 2010
  start-page: 372423
  year: 2010
  ident: CIT0033
  publication-title: Mediators Inflamm
– volume: 44
  start-page: 68
  issue: 1
  year: 2014
  ident: CIT0027
  publication-title: Semin Arthritis Rheum
  doi: 10.1016/j.semarthrit.2014.01.001
– volume: 91
  start-page: 1312
  issue: 10
  year: 2013
  ident: CIT0044
  publication-title: J Neurosci Res
  doi: 10.1002/jnr.23254
– volume: 12
  start-page: 1078
  issue: 8
  year: 2008
  ident: CIT0021
  publication-title: Eur J Pain
  doi: 10.1016/j.ejpain.2008.02.002
– year: 2014
  ident: CIT0019
  publication-title: Eur J Pain
– volume: 41
  start-page: 600
  issue: 7
  year: 2007
  ident: CIT0042
  publication-title: J Psychiatr Res
  doi: 10.1016/j.jpsychires.2006.02.007
– volume: 68
  start-page: 457
  issue: 4
  year: 2008
  ident: CIT0054
  publication-title: Dev Neurobiol
  doi: 10.1002/dneu.20605
– volume: 234
  start-page: 466
  issue: 2
  year: 2012
  ident: CIT0055
  publication-title: Exp Neurol
  doi: 10.1016/j.expneurol.2012.01.021
– volume: 93
  start-page: 2206
  issue: 12
  year: 2012
  ident: CIT0004
  publication-title: Arch Phys Med Rehabil
  doi: 10.1016/j.apmr.2012.06.026
– volume: 24
  start-page: 2089
  issue: 6
  year: 2014
  ident: CIT0130
  publication-title: Biomed Mater Eng
– volume: 138
  start-page: 155
  issue: 2
  year: 2013
  ident: CIT0129
  publication-title: Pharmacol Ther
  doi: 10.1016/j.pharmthera.2013.01.004
– volume: 8
  start-page: 26
  issue: 2
  year: 2013
  ident: CIT0081
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0051149
– volume: 66
  start-page: 375
  issue: 3
  year: 2009
  ident: CIT0026
  publication-title: Cell Mol Life Sci
  doi: 10.1007/s00018-008-8428-0
– volume: 42
  start-page: 884
  issue: 9
  year: 2010
  ident: CIT0105
  publication-title: J Rehabil Med
  doi: 10.2340/16501977-0595
– volume: 30
  start-page: 272
  issue: 3
  year: 2010
  ident: CIT0009
  publication-title: Cephalalgia
  doi: 10.1111/j.1468-2982.2009.01914.x
– volume: 23
  start-page: 259
  issue: 3
  year: 2007
  ident: CIT0028
  publication-title: Mol Cells
  doi: 10.1016/S1016-8478(23)10716-3
– ident: CIT0058
  doi: 10.1111/j.1471-4159.2005.03045.x
– volume: 36
  start-page: S226
  issue: 25
  year: 2011
  ident: CIT0090
  publication-title: Spine (Phila Pa 1976)
  doi: 10.1097/BRS.0b013e3182387fb4
– volume: 13
  start-page: 242
  issue: 3
  year: 2012
  ident: CIT0109
  publication-title: J Pain
  doi: 10.1016/j.jpain.2011.11.006
– volume: 155
  start-page: 906
  issue: 5
  year: 2014
  ident: CIT0131
  publication-title: Pain
  doi: 10.1016/j.pain.2014.01.010
– volume: 154
  start-page: 1792
  issue: 9
  year: 2013
  ident: CIT0079
  publication-title: Pain
  doi: 10.1016/j.pain.2013.05.040
– volume: 18
  start-page: 1169
  issue: 5
  year: 2003
  ident: CIT0061
  publication-title: Eur J Neurosci
  doi: 10.1046/j.1460-9568.2003.02848.x
– volume: 41
  start-page: 556
  issue: 4
  year: 2012
  ident: CIT0012
  publication-title: Semin Arthritis Rheum
  doi: 10.1016/j.semarthrit.2011.08.001
– volume: 23
  start-page: 54
  issue: 1
  year: 2009
  ident: CIT0025
  publication-title: J Orofac Pain
– volume: 27
  start-page: 1289
  issue: 10
  year: 2008
  ident: CIT0041
  publication-title: Clin Rheumatol
  doi: 10.1007/s10067-008-0910-4
– volume: 42
  start-page: 183
  issue: 2
  year: 2005
  ident: CIT0104
  publication-title: J Rehabil Res Dev
  doi: 10.1682/JRRD.2004.06.0065
– volume: 101
  start-page: 229
  issue: 3
  year: 2001
  ident: CIT0034
  publication-title: Acta Neuropathol
  doi: 10.1007/s004010000268
– volume: 79
  start-page: 176
  issue: 2
  year: 2012
  ident: CIT0100
  publication-title: Joint Bone Spine
  doi: 10.1016/j.jbspin.2011.03.019
– volume: 34
  start-page: 1153
  issue: 8
  year: 2014
  ident: CIT0038
  publication-title: Rheumatol
– volume: 17
  start-page: 447
  year: 2014
  ident: CIT0017
  publication-title: Pain Physician
  doi: 10.36076/ppj.2014/17/447
– volume: 137
  start-page: 724
  issue: 3
  year: 2014
  ident: CIT0049
  publication-title: Brain
  doi: 10.1093/brain/awt334
– volume: 2011
  start-page: 650685
  year: 2011
  ident: CIT0111
  publication-title: Int J Inflamm
  doi: 10.4061/2011/650685
– year: 2013
  ident: CIT0125
  publication-title: Eur J Pain
– volume: 12
  start-page: 2963
  issue: 13
  year: 2001
  ident: CIT0119
  publication-title: Neuroreport
  doi: 10.1097/00001756-200109170-00041
– volume-title: Textbook of pain
  year: 1994
  ident: CIT0001
– volume: 189
  start-page: 159
  issue: 1
  year: 2008
  ident: CIT0029
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2007.12.022
– volume: 13
  start-page: 936
  issue: 10
  year: 2012
  ident: CIT0065
  publication-title: J Pain
  doi: 10.1016/j.jpain.2012.07.005
– volume: 289
  start-page: 22196
  issue: 32
  year: 2014
  ident: CIT0039
  publication-title: J Biol
– ident: CIT0074
  doi: 10.1016/j.neuropharm.2014.04.006
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Snippet Introduction: Central sensitization is a form of maladaptive neuroplasticity underlying many chronic pain disorders, including neuropathic pain, fibromyalgia,...
Central sensitization is a form of maladaptive neuroplasticity underlying many chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash,...
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SubjectTerms Animals
Brain-Derived Neurotrophic Factor - metabolism
Central Nervous System Sensitization - physiology
chronic pain
Chronic Pain - physiopathology
Chronic Pain - therapy
Combined Modality Therapy
descending inhibition
exercise
Humans
long-term potentiation
Molecular Targeted Therapy
Neuralgia - physiopathology
Neuralgia - therapy
Neuronal Plasticity - physiology
neuropathic
pharmacotherapy
Signal Transduction - physiology
Title Brain-derived neurotrophic factor as a driving force behind neuroplasticity in neuropathic and central sensitization pain: a new therapeutic target?
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https://www.ncbi.nlm.nih.gov/pubmed/25519921
https://www.proquest.com/docview/1662637530
Volume 19
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