Three Months of Rifapentine and Isoniazid for Latent Tuberculosis Infection

Treatment of latent TB is an important public-health strategy, but 9 months of daily isoniazid (270 doses) poses challenges for compliance. In this study, 3 months of weekly isoniazid plus rifapentine (12 doses) was found to be noninferior to 9 months of isoniazid alone. Tuberculosis results in near...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 365; no. 23; pp. 2155 - 2166
Main Authors:	Sterling, Timothy R, Villarino, M. Elsa, Borisov, Andrey S, Shang, Nong, Gordin, Fred, Bliven-Sizemore, Erin, Hackman, Judith, Hamilton, Carol Dukes, Menzies, Dick, Kerrigan, Amy, Weis, Stephen E, Weiner, Marc, Wing, Diane, Conde, Marcus B, Bozeman, Lorna, Horsburgh, C. Robert, Chaisson, Richard E
Format:	Journal Article
Language:	English
Published:	Waltham, MA Massachusetts Medical Society 08.12.2011
Subjects:	Adult Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antitubercular Agents - administration & dosage Antitubercular Agents - adverse effects Bacterial diseases Biological and medical sciences Directly Observed Therapy Drug Administration Schedule Drug Therapy, Combination Follow-Up Studies General aspects Hepatotoxicity HIV Human bacterial diseases Human immunodeficiency virus Humans Infections Infectious diseases Intention to Treat Analysis Isoniazid Isoniazid - administration & dosage Isoniazid - adverse effects Male Medical sciences Middle Aged Motivation Pharmacology. Drug treatments Prospective Studies Rifampin - administration & dosage Rifampin - adverse effects Rifampin - analogs & derivatives Risk Factors Self Administration Skin Tuberculosis Tuberculosis - drug therapy Tuberculosis - epidemiology Tuberculosis - prevention & control Tuberculosis and atypical mycobacterial infections Virus Latency Infection Medicine Antituberculous agent Antibacterial agent Isoniazid Rifapentine
ISSN:	0028-4793, 1533-4406, 1533-4406
Online Access:	Get full text
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