SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis

Postreplication repair (PRR) pathways play important roles in restarting stalled replication forks and regulating mutagenesis. In yeast, Rad5-mediated damage avoidance and Rad18-mediated translesion synthesis (TLS) are two forms of PRR. Two Rad5-related proteins, SHPRH and HLTF, have been identified...

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Veröffentlicht in:	Molecular cell Jg. 42; H. 2; S. 237
Hauptverfasser:	Lin, Jia-Ren, Zeman, Michelle K, Chen, Jia-Yun, Yee, Muh-Ching, Cimprich, Karlene A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 22.04.2011
Schlagworte:	Cell Nucleus - drug effects Cell Nucleus - enzymology Cell Nucleus - radiation effects DNA Damage DNA Helicases - genetics DNA Helicases - metabolism DNA Repair DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-Directed DNA Polymerase - metabolism Dose-Response Relationship, Drug Dose-Response Relationship, Radiation HEK293 Cells Humans Methyl Methanesulfonate - pharmacology Mutagenesis Mutagens - pharmacology Proliferating Cell Nuclear Antigen - metabolism Protein Processing, Post-Translational Recombinant Fusion Proteins - metabolism RNA Interference Transcription Factors - genetics Transcription Factors - metabolism Transfection Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination Ultraviolet Rays
ISSN:	1097-4164, 1097-4164
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