Determination of clavulanic acid in calf plasma by liquid chromatography tandem mass spectrometry

A method for the quantification of clavulanic acid in calf plasma using high‐performance liquid chromatography combined with electrospray ionization (ESI) mass spectrometry, operating in the negative ionization mode (LC‐MS/MS), is presented. Sample preparation includes a simple and fast deproteiniza...

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Bibliographic Details
Published in:	Journal of mass spectrometry. Vol. 41; no. 11; pp. 1414 - 1420
Main Authors:	Reyns, Tim, De Baere, Siegrid, Croubels, Siska, De Backer, Patrick
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01.11.2006 Wiley
Subjects:	Administration, Oral Amoxicillin - blood Animal productions Animals Biological and medical sciences Cattle Chromatography, High Pressure Liquid Chromatography, Liquid clavulanic acid Clavulanic Acid - administration & dosage Clavulanic Acid - blood Clavulanic Acid - pharmacokinetics Fundamental and applied biological sciences. Psychology liquid chromatography/electrospray ionization tandem mass spectrometry pharmacokinetics Reference Standards Sensitivity and Specificity Spectrometry, Mass, Electrospray Ionization stability Tandem Mass Spectrometry Terrestrial animal productions validation Vertebrates Biological fluid Chemical analysis Clavulanic acid liquid chromatography/electrospray ionization tandem mass spectrometry HPLC chromatography Ox β-Lactamase Solvent extraction Veterinary medicine Electrospray Blood Blood plasma Sample preparation Ungulata Validation Farming animal Stability Enzyme Liquid liquid extraction Coupled method Calf Oral administration Enzyme inhibitor Vertebrata Reversed phase chromatography Mammalia Animal Mass spectrometry MS/MS Hydrolases Artiodactyla Antibacterial agent Pharmacokinetics
ISSN:	1076-5174, 1096-9888
Online Access:	Get full text
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