A Functional Variant Associated with Atrial Fibrillation Regulates PITX2c Expression through TFAP2a

The most significantly associated genetic locus for atrial fibrillation (AF) is in chromosomal region 4q25, where four independent association signals have been identified. Although model-system studies suggest that altered PITX2c expression might underlie the association, the link between specific...

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Vydáno v:	American journal of human genetics Ročník 99; číslo 6; s. 1281
Hlavní autoři:	Ye, Jiangchuan, Tucker, Nathan R, Weng, Lu-Chen, Clauss, Sebastian, Lubitz, Steven A, Ellinor, Patrick T
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.12.2016
Témata:	Alleles Animals Atrial Fibrillation - genetics Chromosomes, Human, Pair 4 - genetics Conserved Sequence - genetics Deoxyribonucleases - metabolism Enhancer Elements, Genetic - genetics Gene Expression Regulation Genetic Predisposition to Disease Histones - chemistry Histones - metabolism Homeobox Protein PITX2 Homeodomain Proteins - genetics Humans Mammals - genetics Myocytes, Cardiac - cytology Polymorphism, Single Nucleotide - genetics Transcription Factor AP-2 - metabolism Transcription Factors - genetics Zebrafish - genetics
ISSN:	1537-6605, 1537-6605
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