Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells

Histone ubiquitination at DNA breaks is required for activation of the DNA damage response (DDR) and DNA repair. How the dynamic removal of this modification by deubiquitinating enzymes (DUBs) impacts genome maintenance in vivo is largely unknown. To address this question, we generated mice deficien...

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Bibliographic Details
Published in:	The Journal of experimental medicine Vol. 211; no. 9; p. 1759
Main Authors:	Lancini, Cesare, van den Berk, Paul C M, Vissers, Joseph H A, Gargiulo, Gaetano, Song, Ji-Ying, Hulsman, Danielle, Serresi, Michela, Tanger, Ellen, Blom, Marleen, Vens, Conchita, van Lohuizen, Maarten, Jacobs, Heinz, Citterio, Elisabetta
Format:	Journal Article
Language:	English
Published:	United States 25.08.2014
Subjects:	Animals Carcinogenesis Cell Proliferation Cellular Senescence DNA Breaks, Double-Stranded DNA Damage - physiology DNA Repair - physiology Female Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Histones - metabolism Homeostasis Lymphopenia - etiology Male Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Ubiquitin-Specific Proteases - deficiency Ubiquitin-Specific Proteases - genetics Ubiquitin-Specific Proteases - metabolism Ubiquitination
ISSN:	1540-9538, 1540-9538
Online Access:	Get more information
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