Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells

Histone ubiquitination at DNA breaks is required for activation of the DNA damage response (DDR) and DNA repair. How the dynamic removal of this modification by deubiquitinating enzymes (DUBs) impacts genome maintenance in vivo is largely unknown. To address this question, we generated mice deficien...

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Veröffentlicht in:	The Journal of experimental medicine Jg. 211; H. 9; S. 1759
Hauptverfasser:	Lancini, Cesare, van den Berk, Paul C M, Vissers, Joseph H A, Gargiulo, Gaetano, Song, Ji-Ying, Hulsman, Danielle, Serresi, Michela, Tanger, Ellen, Blom, Marleen, Vens, Conchita, van Lohuizen, Maarten, Jacobs, Heinz, Citterio, Elisabetta
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 25.08.2014
Schlagworte:	Animals Carcinogenesis Cell Proliferation Cellular Senescence DNA Breaks, Double-Stranded DNA Damage - physiology DNA Repair - physiology Female Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Histones - metabolism Homeostasis Lymphopenia - etiology Male Mice Mice, 129 Strain Mice, Inbred C57BL Mice, Knockout Ubiquitin-Specific Proteases - deficiency Ubiquitin-Specific Proteases - genetics Ubiquitin-Specific Proteases - metabolism Ubiquitination
ISSN:	1540-9538, 1540-9538
Online-Zugang:	Weitere Angaben
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