Roles of the immune system in cancer: from tumor initiation to metastatic progression

The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells; however, as the tumor develops from neopla...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Genes & development Ročník 32; číslo 19-20; s. 1267
Hlavní autoři:	Gonzalez, Hugo, Hagerling, Catharina, Werb, Zena
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.10.2018
Témata:	B-Lymphocytes - immunology Carcinoma - immunology Carcinoma - secondary Dendritic Cells - immunology Disease Progression Humans Immunologic Surveillance Inflammation - immunology Killer Cells, Natural - immunology Macrophages - immunology Neoplasm Metastasis - immunology Neoplasms - immunology Neutrophils - immunology T-Lymphocytes - immunology disseminated tumor cells immune cross-talk patient-derived xenograft cancer heterogeneity metastasis-associated immune cells tumor-associated macrophages
ISSN:	1549-5477, 1549-5477
On-line přístup:	Zjistit podrobnosti o přístupu
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Abstract	The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells; however, as the tumor develops from neoplastic tissue to clinically detectable tumors, cancer cells evolve different mechanisms that mimic peripheral immune tolerance in order to avoid tumoricidal attack. Here, we provide an update of recent accomplishments, unifying concepts, and future challenges to study tumor-associated immune cells, with an emphasis on metastatic carcinomas.
AbstractList	The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells; however, as the tumor develops from neoplastic tissue to clinically detectable tumors, cancer cells evolve different mechanisms that mimic peripheral immune tolerance in order to avoid tumoricidal attack. Here, we provide an update of recent accomplishments, unifying concepts, and future challenges to study tumor-associated immune cells, with an emphasis on metastatic carcinomas.The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells; however, as the tumor develops from neoplastic tissue to clinically detectable tumors, cancer cells evolve different mechanisms that mimic peripheral immune tolerance in order to avoid tumoricidal attack. Here, we provide an update of recent accomplishments, unifying concepts, and future challenges to study tumor-associated immune cells, with an emphasis on metastatic carcinomas. The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune attack? In principle, tumor development can be controlled by cytotoxic innate and adaptive immune cells; however, as the tumor develops from neoplastic tissue to clinically detectable tumors, cancer cells evolve different mechanisms that mimic peripheral immune tolerance in order to avoid tumoricidal attack. Here, we provide an update of recent accomplishments, unifying concepts, and future challenges to study tumor-associated immune cells, with an emphasis on metastatic carcinomas.
Author	Werb, Zena Hagerling, Catharina Gonzalez, Hugo
Author_xml	– sequence: 1 givenname: Hugo surname: Gonzalez fullname: Gonzalez, Hugo organization: Department of Anatomy, the Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA – sequence: 2 givenname: Catharina surname: Hagerling fullname: Hagerling, Catharina organization: Department of Anatomy, the Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA – sequence: 3 givenname: Zena orcidid: 0000-0002-6525-3872 surname: Werb fullname: Werb, Zena organization: Department of Anatomy, the Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94143, USA
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/30275043$$D View this record in MEDLINE/PubMed
BookMark	eNpNkM1LAzEQxYNU7IdePUqOXrZmkt1k602KX1AQpJ6XbDqpkc2mbrKH_vcGrOBp3m_m8R7MnEz60CMh18CWAAzu9nq3FFBKUJnrMzKDqlwVVanU5J-eknmMX4wxyaS8IFPBuKpYKWbk4z10GGmwNH0idd6PPdJ4jAk9dT01ujc43FM7BE_T6MOQty45nVzoaQrUY9IxZTT0MIT9gDHmyyU5t7qLeHWaC7J9etyuX4rN2_Pr-mFTmLIWqUCuuBErsIzvlGhRtLqVgC1rpVJCy1pl1gBY1aUUIKywtpVmxTSYCku-ILe_sbn6e8SYGu-iwa7TPYYxNhygUlWOqbP15mQdW4-75jA4r4dj8_cJ_gNolGKa
CitedBy_id	crossref_primary_10_1016_j_devcel_2023_05_010 crossref_primary_10_1016_j_modpat_2024_100624 crossref_primary_10_1016_j_pharmthera_2021_108052 crossref_primary_10_3390_ijms222212409 crossref_primary_10_1007_s12672_025_02859_8 crossref_primary_10_1016_j_lungcan_2020_03_018 crossref_primary_10_1186_s12885_025_14118_8 crossref_primary_10_3390_biomedicines11010107 crossref_primary_10_1016_j_ejca_2020_06_009 crossref_primary_10_1016_j_bbii_2024_100088 crossref_primary_10_1016_j_cellsig_2025_111843 crossref_primary_10_1016_j_oor_2024_100622 crossref_primary_10_1002_1878_0261_13649 crossref_primary_10_1016_j_chaos_2025_116969 crossref_primary_10_1002_pro_4486 crossref_primary_10_3389_fcell_2021_795133 crossref_primary_10_3389_fimmu_2022_813015 crossref_primary_10_1038_s41388_022_02288_9 crossref_primary_10_1016_j_prp_2025_155864 crossref_primary_10_1016_j_prp_2024_155120 crossref_primary_10_1093_bib_bbab003 crossref_primary_10_3390_ijms25147974 crossref_primary_10_1016_j_taap_2022_115863 crossref_primary_10_3390_diagnostics15162019 crossref_primary_10_1038_s41392_024_01885_2 crossref_primary_10_3390_cancers13112788 crossref_primary_10_1590_0001_3765202020191500 crossref_primary_10_3389_fimmu_2019_02801 crossref_primary_10_3389_fchem_2021_686303 crossref_primary_10_1038_s41392_021_00658_5 crossref_primary_10_1016_j_canlet_2020_04_016 crossref_primary_10_1016_j_ebiom_2020_103137 crossref_primary_10_3389_fonc_2024_1308651 crossref_primary_10_3389_fonc_2020_00992 crossref_primary_10_3390_cancers13246388 crossref_primary_10_3389_fonc_2019_00626 crossref_primary_10_2147_IJN_S317626 crossref_primary_10_1007_s12032_021_01488_9 crossref_primary_10_3390_metabo14120683 crossref_primary_10_3390_biom10060933 crossref_primary_10_3390_biomedicines10061268 crossref_primary_10_1016_j_addr_2022_114365 crossref_primary_10_3389_fimmu_2022_894021 crossref_primary_10_1016_j_intimp_2022_108727 crossref_primary_10_3390_antiox12061210 crossref_primary_10_1016_j_tcb_2020_10_002 crossref_primary_10_1002_1878_0261_12773 crossref_primary_10_1016_j_adcanc_2025_100147 crossref_primary_10_1186_s12885_024_13003_0 crossref_primary_10_1016_j_matdes_2023_112202 crossref_primary_10_3390_math11204226 crossref_primary_10_1016_j_pharmthera_2022_108114 crossref_primary_10_1159_000507055 crossref_primary_10_3389_fmolb_2020_611847 crossref_primary_10_1158_2159_8290_CD_24_0861 crossref_primary_10_7717_peerj_18719 crossref_primary_10_1016_j_bbcan_2025_189390 crossref_primary_10_1038_s12276_024_01163_9 crossref_primary_10_1111_cas_16425 crossref_primary_10_1186_s12929_022_00796_0 crossref_primary_10_3389_fcell_2022_861000 crossref_primary_10_1002_adfm_202307433 crossref_primary_10_1186_s13048_019_0557_6 crossref_primary_10_1038_s41467_022_30874_8 crossref_primary_10_3390_cells13100844 crossref_primary_10_3389_fimmu_2023_1228458 crossref_primary_10_1016_j_ejca_2019_09_002 crossref_primary_10_1016_j_omtn_2020_07_024 crossref_primary_10_3390_cancers16020470 crossref_primary_10_7759_cureus_52890 crossref_primary_10_1186_s40001_025_02497_4 crossref_primary_10_1016_j_jconrel_2021_07_040 crossref_primary_10_1038_s12276_023_01090_1 crossref_primary_10_1016_j_disamonth_2022_101353 crossref_primary_10_1186_s12885_025_14432_1 crossref_primary_10_1016_j_intimp_2024_112564 crossref_primary_10_1016_j_labinv_2025_104223 crossref_primary_10_3389_fimmu_2023_1239151 crossref_primary_10_3390_ph17121591 crossref_primary_10_1007_s42485_021_00056_z crossref_primary_10_1186_s12931_023_02327_3 crossref_primary_10_1165_rcmb_2023_0410OC crossref_primary_10_3390_jof9080812 crossref_primary_10_1038_s41587_025_02629_5 crossref_primary_10_3389_fmolb_2024_1361377 crossref_primary_10_1016_j_canlet_2020_11_034 crossref_primary_10_3390_cancers17111847 crossref_primary_10_1210_endocr_bqab152 crossref_primary_10_1016_j_cellsig_2024_111507 crossref_primary_10_1136_bmjresp_2021_001194 crossref_primary_10_1038_s41467_025_57123_y crossref_primary_10_3390_ijms22094384 crossref_primary_10_1080_14712598_2025_2484305 crossref_primary_10_1016_j_ccell_2024_03_011 crossref_primary_10_1016_j_clim_2023_109637 crossref_primary_10_3389_fimmu_2024_1433185 crossref_primary_10_1002_smtd_202201307 crossref_primary_10_1007_s11033_021_06876_y crossref_primary_10_1002_1878_0261_13614 crossref_primary_10_3390_cancers13081926 crossref_primary_10_1103_xjh4_mfvx crossref_primary_10_3390_ijms21207504 crossref_primary_10_3389_fonc_2021_720951 crossref_primary_10_3390_ijms22052550 crossref_primary_10_3390_cancers14061539 crossref_primary_10_3390_ph14040337 crossref_primary_10_1021_acs_jmedchem_5c02098 crossref_primary_10_1155_2021_6694392 crossref_primary_10_1002_ijc_34911 crossref_primary_10_1038_s41467_021_20935_9 crossref_primary_10_1016_j_cmpb_2024_108421 crossref_primary_10_1186_s12935_023_03136_w crossref_primary_10_3390_cancers15174266 crossref_primary_10_1016_j_intimp_2020_107238 crossref_primary_10_1002_cam4_70798 crossref_primary_10_1016_j_pdpdt_2020_102034 crossref_primary_10_1016_j_bja_2019_04_062 crossref_primary_10_3389_fimmu_2021_670324 crossref_primary_10_1016_j_coi_2021_09_004 crossref_primary_10_3233_TUB_210001 crossref_primary_10_3389_fimmu_2025_1655176 crossref_primary_10_3389_fimmu_2020_01624 crossref_primary_10_3389_fonc_2022_873722 crossref_primary_10_3390_pharmaceutics14122709 crossref_primary_10_3390_cancers16112003 crossref_primary_10_1097_MD_0000000000031113 crossref_primary_10_1016_j_clbc_2025_08_003 crossref_primary_10_3389_fgene_2022_1016085 crossref_primary_10_1016_j_molmet_2024_101964 crossref_primary_10_3389_fonc_2021_732702 crossref_primary_10_1007_s13346_021_01040_2 crossref_primary_10_1016_j_bcp_2024_116231 crossref_primary_10_3892_or_2024_8846 crossref_primary_10_1038_s41590_024_01932_8 crossref_primary_10_3390_cancers13051086 crossref_primary_10_1002_ctm2_70319 crossref_primary_10_1007_s00262_025_04074_4 crossref_primary_10_1159_000522000 crossref_primary_10_1177_1534735419886655 crossref_primary_10_1016_j_ejrad_2024_111441 crossref_primary_10_3390_jpm12060958 crossref_primary_10_1063_5_0011583 crossref_primary_10_3389_fonc_2020_605633 crossref_primary_10_1186_s43682_022_00011_z crossref_primary_10_1038_s41467_025_58662_0 crossref_primary_10_1186_s12935_020_01179_x crossref_primary_10_3389_fimmu_2024_1336023 crossref_primary_10_1186_s40164_024_00549_9 crossref_primary_10_3390_cancers12092351 crossref_primary_10_1080_1040841X_2022_2035313 crossref_primary_10_3390_cancers14071716 crossref_primary_10_3390_genes15050531 crossref_primary_10_1016_j_micres_2024_127871 crossref_primary_10_1186_s43556_022_00109_9 crossref_primary_10_3389_fimmu_2020_620166 crossref_primary_10_1016_j_critrevonc_2024_104311 crossref_primary_10_1007_s10456_020_09734_w crossref_primary_10_3390_ijms252313113 crossref_primary_10_1093_genetics_iyac095 crossref_primary_10_1111_bcp_14979 crossref_primary_10_3390_biom10030477 crossref_primary_10_3389_fimmu_2021_716469 crossref_primary_10_3389_fonc_2020_01698 crossref_primary_10_1007_s00262_021_02866_y crossref_primary_10_1093_bib_bbab408 crossref_primary_10_3390_bioengineering10040485 crossref_primary_10_1186_s12885_024_12014_1 crossref_primary_10_1016_j_immuni_2021_08_019 crossref_primary_10_1186_s13073_024_01294_8 crossref_primary_10_1007_s12274_024_6492_x crossref_primary_10_2147_IJGM_S338135 crossref_primary_10_14309_crj_0000000000000834 crossref_primary_10_3390_biomedicines10081987 crossref_primary_10_3390_molecules26082201 crossref_primary_10_1016_j_lfs_2020_118035 crossref_primary_10_1186_s10020_025_01264_9 crossref_primary_10_3390_ijms25168854 crossref_primary_10_3390_medicina60050721 crossref_primary_10_3390_cancers14041053 crossref_primary_10_1093_bib_bbaa300 crossref_primary_10_3389_fonc_2021_762709 crossref_primary_10_1038_s41598_022_07628_z crossref_primary_10_1161_ATVBAHA_124_319870 crossref_primary_10_1111_odi_13542 crossref_primary_10_7554_eLife_50731 crossref_primary_10_1007_s10867_019_09535_3 crossref_primary_10_1016_j_ebiom_2024_105031 crossref_primary_10_3389_fimmu_2024_1504220 crossref_primary_10_1016_j_semcancer_2021_01_007 crossref_primary_10_1007_s00432_019_03041_8 crossref_primary_10_1016_j_scitotenv_2024_170178 crossref_primary_10_3390_biomedicines10051065 crossref_primary_10_1016_j_heliyon_2024_e37092 crossref_primary_10_3389_fimmu_2025_1563858 crossref_primary_10_3390_v14040812 crossref_primary_10_1016_j_heliyon_2024_e41358 crossref_primary_10_3389_fimmu_2022_1066359 crossref_primary_10_3390_cancers12102902 crossref_primary_10_1097_CMR_0000000000000783 crossref_primary_10_1177_00368504211011836 crossref_primary_10_1016_j_bcp_2024_116048 crossref_primary_10_1038_s41598_020_79260_8 crossref_primary_10_1007_s13206_020_4201_8 crossref_primary_10_3390_cancers15205060 crossref_primary_10_1016_j_bbcan_2025_189328 crossref_primary_10_1016_j_oraloncology_2023_106556 crossref_primary_10_1002_ijc_33860 crossref_primary_10_1007_s11094_024_03159_1 crossref_primary_10_1007_s12032_023_02184_6 crossref_primary_10_1007_s13346_023_01378_9 crossref_primary_10_1186_s13073_022_01141_8 crossref_primary_10_3390_biology13100816 crossref_primary_10_3390_vaccines10101764 crossref_primary_10_1080_2162402X_2021_1896643 crossref_primary_10_1016_j_matdes_2023_111750 crossref_primary_10_1016_j_phymed_2022_153939 crossref_primary_10_1002_cm_22041 crossref_primary_10_1136_bmjopen_2019_034522 crossref_primary_10_1016_j_cyto_2021_155760 crossref_primary_10_1038_s41598_024_52153_w crossref_primary_10_1111_pin_70037 crossref_primary_10_3390_cancers13010127 crossref_primary_10_3390_cancers14184410 crossref_primary_10_1080_08830185_2024_2333275 crossref_primary_10_3389_fimmu_2022_920253 crossref_primary_10_3390_ijms21113969 crossref_primary_10_1016_j_actbio_2024_02_010 crossref_primary_10_1186_s12014_022_09362_0 crossref_primary_10_1016_j_jlb_2025_100312 crossref_primary_10_3389_fimmu_2021_730765 crossref_primary_10_3390_cancers15184526 crossref_primary_10_3389_fonc_2021_785850 crossref_primary_10_3390_cancers14092216 crossref_primary_10_1016_j_micres_2023_127392 crossref_primary_10_3389_fonc_2022_897968 crossref_primary_10_3390_sym16060676 crossref_primary_10_1097_JCMA_0000000000000283 crossref_primary_10_3389_fonc_2022_896633 crossref_primary_10_1016_j_radonc_2022_07_014 crossref_primary_10_3389_fimmu_2020_02105 crossref_primary_10_1016_j_jbc_2023_102935 crossref_primary_10_1007_s00253_022_11839_9 crossref_primary_10_1016_j_jtbi_2022_111383 crossref_primary_10_1080_87559129_2020_1817065 crossref_primary_10_3389_fimmu_2021_771201 crossref_primary_10_1134_S1990519X23060111 crossref_primary_10_1186_s13046_022_02439_6 crossref_primary_10_3389_fonc_2020_00562 crossref_primary_10_2147_OTT_S259516 crossref_primary_10_3389_fonc_2024_1360358 crossref_primary_10_1038_s41598_020_77657_z crossref_primary_10_3390_cancers13153725 crossref_primary_10_3390_cancers16162797 crossref_primary_10_1016_j_mehy_2021_110663 crossref_primary_10_1002_pros_24432 crossref_primary_10_3389_fonc_2020_00317 crossref_primary_10_3389_fonc_2022_1020121 crossref_primary_10_1038_s42003_021_02296_7 crossref_primary_10_1016_j_bios_2023_115644 crossref_primary_10_1016_j_phrs_2022_106364 crossref_primary_10_1038_s41598_023_49441_2 crossref_primary_10_1007_s00018_020_03696_4 crossref_primary_10_3389_fonc_2020_576615 crossref_primary_10_3390_microorganisms9051021 crossref_primary_10_1007_s11481_021_10018_3 crossref_primary_10_1007_s12032_025_02862_7 crossref_primary_10_2147_CCID_S500654 crossref_primary_10_1111_jcmm_15443 crossref_primary_10_1111_ejh_14103 crossref_primary_10_3389_fonc_2025_1585433 crossref_primary_10_1016_j_semcancer_2021_02_004 crossref_primary_10_1038_s41571_022_00699_x crossref_primary_10_1007_s00438_023_02022_4 crossref_primary_10_1016_j_prp_2023_154846 crossref_primary_10_1038_s41598_023_28653_6 crossref_primary_10_1016_j_cellsig_2023_111014 crossref_primary_10_1158_0008_5472_CAN_20_1852 crossref_primary_10_1016_j_genrep_2021_101403 crossref_primary_10_1080_10408398_2024_2354937 crossref_primary_10_1186_s11658_021_00293_6 crossref_primary_10_3390_ijms26010088 crossref_primary_10_3389_fphar_2022_833584 crossref_primary_10_4155_tde_2020_0028 crossref_primary_10_2147_JIR_S401451 crossref_primary_10_1016_j_tox_2021_152840 crossref_primary_10_3389_fimmu_2019_02876 crossref_primary_10_3390_cancers15092531 crossref_primary_10_1002_jgm_3441 crossref_primary_10_1007_s00044_024_03333_w crossref_primary_10_1186_s13046_022_02590_0 crossref_primary_10_3390_cancers17091547 crossref_primary_10_1038_s41577_021_00540_z crossref_primary_10_1097_HC9_0000000000000668 crossref_primary_10_1016_j_psyneuen_2021_105163 crossref_primary_10_2174_0929867327999200817104912 crossref_primary_10_1038_s41416_023_02191_4 crossref_primary_10_1002_jcsm_13517 crossref_primary_10_57603_EJT_1546 crossref_primary_10_1007_s10637_020_00921_6 crossref_primary_10_1155_2021_6649314 crossref_primary_10_1186_s12967_019_02194_x crossref_primary_10_3389_fonc_2022_911309 crossref_primary_10_1038_s41434_025_00550_9 crossref_primary_10_1038_s41433_023_02434_x crossref_primary_10_1016_j_ijpharm_2024_124057 crossref_primary_10_1002_pon_5851 crossref_primary_10_3390_ijms242316771 crossref_primary_10_3389_fonc_2023_1228076 crossref_primary_10_1126_science_abc1944 crossref_primary_10_1016_j_ijbiomac_2025_143440 crossref_primary_10_1002_adbi_202000035 crossref_primary_10_1007_s40134_020_00369_9 crossref_primary_10_3390_cancers15113014 crossref_primary_10_1038_s41467_025_57697_7 crossref_primary_10_1186_s13046_023_02835_6 crossref_primary_10_1186_s12929_022_00866_3 crossref_primary_10_3389_fbioe_2023_1150764 crossref_primary_10_1007_s00262_022_03280_8 crossref_primary_10_1038_s41467_020_17873_3 crossref_primary_10_3390_ani10081437 crossref_primary_10_3390_cancers16040683 crossref_primary_10_3390_bioengineering11010093 crossref_primary_10_2147_OTT_S234819 crossref_primary_10_1038_s42003_024_06812_3 crossref_primary_10_3892_mco_2023_2625 crossref_primary_10_1080_14737159_2023_2246893 crossref_primary_10_1007_s11538_024_01323_y crossref_primary_10_1158_0008_5472_CAN_22_1270 crossref_primary_10_3390_biomedicines9040359 crossref_primary_10_1186_s12951_022_01458_x crossref_primary_10_2147_CMAR_S259197 crossref_primary_10_3390_biomedicines9040374 crossref_primary_10_3390_ijms231810906 crossref_primary_10_3390_cancers16173085 crossref_primary_10_1007_s12035_021_02544_1 crossref_primary_10_1016_j_csbj_2020_08_001 crossref_primary_10_3389_fimmu_2022_1024224 crossref_primary_10_1007_s11764_021_01126_3 crossref_primary_10_1080_07357907_2021_1960992 crossref_primary_10_7717_peerj_19148 crossref_primary_10_3390_biology13100765 crossref_primary_10_3390_cancers14133213 crossref_primary_10_3390_molecules28155804 crossref_primary_10_1016_j_ejca_2020_11_033 crossref_primary_10_1177_11795549211035540 crossref_primary_10_1016_j_bioactmat_2024_10_010 crossref_primary_10_1177_10732748251349919 crossref_primary_10_1080_14737140_2023_2181162 crossref_primary_10_1186_s12967_021_02829_y crossref_primary_10_2217_fon_2023_0545 crossref_primary_10_1016_j_canlet_2021_02_004 crossref_primary_10_1016_j_intimp_2022_109011 crossref_primary_10_1093_omcr_omad076 crossref_primary_10_3390_cancers16030612 crossref_primary_10_1016_j_jconrel_2023_05_018 crossref_primary_10_1016_j_lfs_2022_120761 crossref_primary_10_3390_cancers15123080 crossref_primary_10_2147_JIR_S460109 crossref_primary_10_1016_j_tifs_2021_03_008 crossref_primary_10_1038_s41556_020_00628_z crossref_primary_10_1073_pnas_2421060122 crossref_primary_10_3389_fonc_2021_688896 crossref_primary_10_1007_s10787_021_00796_w crossref_primary_10_1016_j_nantod_2020_101045 crossref_primary_10_1038_s41392_020_00436_9 crossref_primary_10_1038_s41416_021_01338_5 crossref_primary_10_3389_fonc_2021_649004 crossref_primary_10_3389_fonc_2021_667715 crossref_primary_10_1016_j_apsb_2023_03_004 crossref_primary_10_1016_j_ajog_2022_06_056 crossref_primary_10_1208_s12249_024_02883_x crossref_primary_10_1186_s12876_020_1177_8 crossref_primary_10_3389_fonc_2021_716042 crossref_primary_10_1186_s13059_022_02828_2 crossref_primary_10_4049_jimmunol_2300642 crossref_primary_10_1002_adtp_202000267 crossref_primary_10_3390_cancers15245847 crossref_primary_10_3390_vaccines11111701 crossref_primary_10_1002_cam4_4755 crossref_primary_10_1016_j_prp_2022_154295 crossref_primary_10_3390_mi11090849 crossref_primary_10_1038_s41467_023_41101_3 crossref_primary_10_2340_actadv_v104_27571 crossref_primary_10_1038_s41467_025_59186_3 crossref_primary_10_1111_srt_13782 crossref_primary_10_3389_fimmu_2024_1458884 crossref_primary_10_1371_journal_pone_0289519 crossref_primary_10_3390_cancers14194887 crossref_primary_10_3390_molecules28135152 crossref_primary_10_3389_fcell_2021_748631 crossref_primary_10_1016_j_actbio_2021_04_034 crossref_primary_10_3389_fimmu_2025_1529847 crossref_primary_10_1038_s41598_022_06427_w crossref_primary_10_2147_JIR_S492356 crossref_primary_10_2147_DDDT_S286529 crossref_primary_10_1016_j_addr_2022_114504 crossref_primary_10_1177_00368504241304195 crossref_primary_10_1111_fcp_70008 crossref_primary_10_3389_fonc_2024_1347650 crossref_primary_10_1002_jcp_30907 crossref_primary_10_1155_2023_8646088 crossref_primary_10_1111_imm_13455 crossref_primary_10_1007_s12094_022_02950_4 crossref_primary_10_1016_j_ygyno_2022_07_010 crossref_primary_10_1111_imm_13694 crossref_primary_10_1371_journal_pone_0266827 crossref_primary_10_3390_cancers15010216 crossref_primary_10_1002_1878_0261_13063 crossref_primary_10_1186_s13036_023_00372_6 crossref_primary_10_1016_j_trecan_2025_02_006 crossref_primary_10_1111_1759_7714_15493 crossref_primary_10_3390_ijms22010265 crossref_primary_10_1186_s40164_025_00689_6 crossref_primary_10_1038_s41568_023_00602_5 crossref_primary_10_1016_j_actbio_2021_04_041 crossref_primary_10_1016_j_biomaterials_2022_121550 crossref_primary_10_1016_j_rvsc_2025_105807 crossref_primary_10_3390_cancers17132162 crossref_primary_10_3389_fimmu_2025_1575452 crossref_primary_10_3389_fphar_2022_1034129 crossref_primary_10_1136_jitc_2022_005845 crossref_primary_10_1007_s00432_022_04084_0 crossref_primary_10_1007_s12672_022_00562_6 crossref_primary_10_1016_j_engmed_2024_100027 crossref_primary_10_1016_j_it_2020_11_006 crossref_primary_10_1093_gigascience_giad010 crossref_primary_10_1038_s41586_023_06367_z crossref_primary_10_1016_j_cell_2021_12_043 crossref_primary_10_1186_s12935_024_03227_2 crossref_primary_10_4251_wjgo_v16_i3_919 crossref_primary_10_2174_0115734099266822231219073332 crossref_primary_10_3390_cancers15010206 crossref_primary_10_3390_cancers13205159 crossref_primary_10_1038_s41392_024_01979_x crossref_primary_10_3748_wjg_v26_i33_4900 crossref_primary_10_1002_advs_202204335 crossref_primary_10_1016_j_drudis_2020_11_029 crossref_primary_10_1016_j_humimm_2021_06_007 crossref_primary_10_3389_fimmu_2020_01077 crossref_primary_10_1186_s41181_022_00163_2 crossref_primary_10_1016_j_bbrc_2020_10_037 crossref_primary_10_1186_s12967_024_05393_3 crossref_primary_10_1016_j_ejphar_2023_175611 crossref_primary_10_1016_j_semcancer_2022_02_016 crossref_primary_10_1177_11795549241311408 crossref_primary_10_3389_fvets_2021_760603 crossref_primary_10_1038_s41409_025_02718_8 crossref_primary_10_4274_imj_galenos_2025_59254 crossref_primary_10_3389_fnut_2023_1259929 crossref_primary_10_2147_OTT_S242018 crossref_primary_10_3390_molecules27123742 crossref_primary_10_32604_biocell_2024_046178 crossref_primary_10_1093_carcin_bgaa092 crossref_primary_10_3389_fimmu_2024_1422717 crossref_primary_10_1016_j_brainres_2020_146650 crossref_primary_10_1155_sci5_4211238 crossref_primary_10_1016_j_semcancer_2022_02_005 crossref_primary_10_3390_biology12091230 crossref_primary_10_3390_cancers15020466 crossref_primary_10_1177_17588359221144108 crossref_primary_10_1186_s12890_023_02809_6 crossref_primary_10_1016_j_nano_2021_102415 crossref_primary_10_17816_KMJ636640 crossref_primary_10_3390_cancers14143429 crossref_primary_10_1080_09553002_2019_1564082 crossref_primary_10_3390_ijms23126374 crossref_primary_10_1007_s10238_023_01201_2 crossref_primary_10_1051_shsconf_202317403004 crossref_primary_10_1111_sji_13137 crossref_primary_10_1186_s12943_025_02337_3 crossref_primary_10_3390_jcm13237248 crossref_primary_10_1155_2022_7356992 crossref_primary_10_12688_f1000research_27952_1 crossref_primary_10_4252_wjsc_v12_i11_1307 crossref_primary_10_1007_s12672_025_02291_y crossref_primary_10_1080_2162402X_2020_1824644 crossref_primary_10_3389_fphar_2022_874637 crossref_primary_10_1016_j_lfs_2024_122528 crossref_primary_10_12688_f1000research_27952_2 crossref_primary_10_1007_s40484_020_0212_7 crossref_primary_10_1093_nutrit_nuae108 crossref_primary_10_3390_cancers14133044 crossref_primary_10_3390_cancers14102545 crossref_primary_10_3390_cancers17142392 crossref_primary_10_1016_j_carbpol_2020_116715 crossref_primary_10_1007_s00018_020_03581_0 crossref_primary_10_3390_ijms21134585 crossref_primary_10_1186_s12957_020_02059_4 crossref_primary_10_1097_PAI_0000000000001139 crossref_primary_10_1186_s40001_024_01711_z crossref_primary_10_1038_s42003_025_07710_y crossref_primary_10_2147_CMAR_S238643 crossref_primary_10_3389_fgene_2022_835540 crossref_primary_10_1002_1878_0261_13260 crossref_primary_10_3390_ijms22063137 crossref_primary_10_1016_j_ejphar_2021_173921 crossref_primary_10_3390_cancers14030843 crossref_primary_10_3389_fonc_2025_1598170 crossref_primary_10_1007_s12672_024_01253_0 crossref_primary_10_1186_s12885_024_11889_4 crossref_primary_10_1002_EXP_20210106 crossref_primary_10_1186_s12302_025_01156_z crossref_primary_10_3389_fonc_2019_01556 crossref_primary_10_3390_ijms26136310 crossref_primary_10_3389_fimmu_2024_1430551 crossref_primary_10_1007_s00262_024_03704_7 crossref_primary_10_3390_cells9041018 crossref_primary_10_3390_cancers13051100 crossref_primary_10_52711_0975_4385_2024_00052 crossref_primary_10_1016_j_phrs_2020_105231 crossref_primary_10_1155_2021_9972927 crossref_primary_10_1186_s12935_023_03058_7 crossref_primary_10_3390_cells9020335 crossref_primary_10_1007_s40487_024_00299_y crossref_primary_10_1002_biof_1867 crossref_primary_10_1016_j_isci_2022_104492 crossref_primary_10_1177_15330338211038488 crossref_primary_10_1186_s12916_022_02670_0 crossref_primary_10_3389_fimmu_2025_1621812 crossref_primary_10_1186_s12894_024_01569_7 crossref_primary_10_1186_s12985_025_02771_1 crossref_primary_10_1007_s00428_023_03577_8 crossref_primary_10_1038_s41366_020_0549_z crossref_primary_10_3390_jcm10010136 crossref_primary_10_3389_fimmu_2020_609948 crossref_primary_10_1002_ggn2_202300201 crossref_primary_10_3390_pharmaceutics12010062 crossref_primary_10_3390_cells12131673 crossref_primary_10_3390_biology12020280 crossref_primary_10_3390_immuno5010001 crossref_primary_10_1073_pnas_2010103117 crossref_primary_10_3390_genes11010006 crossref_primary_10_1016_j_lfs_2024_122506 crossref_primary_10_1007_s13346_022_01282_8 crossref_primary_10_1039_D4MO00112E crossref_primary_10_1097_MD_0000000000043523 crossref_primary_10_1016_j_bprint_2022_e00243 crossref_primary_10_3390_immuno1020007 crossref_primary_10_1002_adhm_202202279 crossref_primary_10_3390_jcm13071920 crossref_primary_10_3390_life15060971 crossref_primary_10_1111_imm_13871 crossref_primary_10_1177_15330338251359716 crossref_primary_10_3390_cancers13061353 crossref_primary_10_1002_adhm_202400323 crossref_primary_10_1007_s11538_025_01466_6 crossref_primary_10_1016_j_semcancer_2020_11_022 crossref_primary_10_3389_fphar_2024_1416705 crossref_primary_10_1186_s13045_020_00893_3 crossref_primary_10_1002_1873_3468_70010 crossref_primary_10_1016_j_humpath_2022_04_012 crossref_primary_10_1016_j_lfs_2024_122978 crossref_primary_10_3390_cancers16132393 crossref_primary_10_1016_j_jconrel_2023_04_001 crossref_primary_10_1007_s13402_023_00773_1 crossref_primary_10_1007_s11307_025_02010_7 crossref_primary_10_1002_advs_202405084 crossref_primary_10_1007_s12192_021_01211_7 crossref_primary_10_1158_2159_8290_CD_22_0427 crossref_primary_10_1016_j_micromeso_2021_110967 crossref_primary_10_3389_fonc_2024_1399047 crossref_primary_10_1016_j_clinbiochem_2021_06_007 crossref_primary_10_1007_s00262_025_04050_y crossref_primary_10_1111_faf_12803 crossref_primary_10_3390_cancers12051337 crossref_primary_10_3390_biom11010065 crossref_primary_10_1016_j_molimm_2020_03_012 crossref_primary_10_1038_s41375_024_02405_5 crossref_primary_10_1038_s41391_021_00392_7 crossref_primary_10_3390_pharmaceutics15020452 crossref_primary_10_1016_j_omton_2025_200975 crossref_primary_10_1016_j_jhazmat_2021_127769 crossref_primary_10_7554_eLife_95106_3 crossref_primary_10_3390_cancers14246058 crossref_primary_10_3390_life12050706 crossref_primary_10_1007_s11010_021_04099_0 crossref_primary_10_1080_14737140_2023_2173175 crossref_primary_10_1097_TP_0000000000004487 crossref_primary_10_1016_j_trecan_2025_04_004 crossref_primary_10_1002_cac2_12620 crossref_primary_10_3390_cancers14051359 crossref_primary_10_3389_fimmu_2024_1500676 crossref_primary_10_1186_s13027_021_00395_y crossref_primary_10_3390_cells11223551 crossref_primary_10_1186_s12890_022_02095_8 crossref_primary_10_1016_j_jksus_2021_101708 crossref_primary_10_3390_cancers13164171 crossref_primary_10_3390_ijms24076216 crossref_primary_10_1134_S1022795421100069 crossref_primary_10_1016_j_critrevonc_2022_103799 crossref_primary_10_3389_fonc_2025_1657392 crossref_primary_10_3390_cancers15102729 crossref_primary_10_1016_j_apsb_2023_08_034 crossref_primary_10_1016_j_heliyon_2023_e16261 crossref_primary_10_1002_jbt_23067 crossref_primary_10_1016_j_jhazmat_2025_138798 crossref_primary_10_1002_cbin_11701 crossref_primary_10_1136_jitc_2020_001524 crossref_primary_10_3390_biomedicines11102706 crossref_primary_10_1186_s40824_023_00343_4 crossref_primary_10_1177_17588359221110176 crossref_primary_10_1098_rsif_2024_0710 crossref_primary_10_3390_ijms22126560 crossref_primary_10_2147_CMAR_S265828 crossref_primary_10_3390_molecules29091913 crossref_primary_10_1158_1940_6207_CAPR_23_0423 crossref_primary_10_3389_fdmed_2023_1116402 crossref_primary_10_1096_fj_202001581RR crossref_primary_10_1002_cmdc_202300305 crossref_primary_10_1016_j_prp_2025_155818 crossref_primary_10_1080_14756366_2022_2085694 crossref_primary_10_3389_fonc_2022_863094 crossref_primary_10_1177_03000605251331250 crossref_primary_10_1186_s12885_024_12239_0 crossref_primary_10_1186_s13046_024_03117_5 crossref_primary_10_3389_fcell_2021_730726 crossref_primary_10_1186_s12920_021_01010_0 crossref_primary_10_1016_j_mbs_2024_109186 crossref_primary_10_3390_ijms26157218 crossref_primary_10_1038_s41568_020_00320_2 crossref_primary_10_3389_fonc_2021_735803 crossref_primary_10_1016_j_lfs_2020_118956 crossref_primary_10_1182_blood_2021014495 crossref_primary_10_1016_j_bbrc_2022_04_125 crossref_primary_10_1007_s10495_025_02080_6 crossref_primary_10_1016_j_jconrel_2024_12_056 crossref_primary_10_3389_fonc_2021_671333 crossref_primary_10_1002_vms3_909 crossref_primary_10_1002_adma_202107406 crossref_primary_10_1002_wdev_394 crossref_primary_10_1016_j_fct_2020_111418 crossref_primary_10_1038_s44319_025_00370_3 crossref_primary_10_7759_cureus_56868 crossref_primary_10_3389_fimmu_2022_823225 crossref_primary_10_1016_j_bbcan_2023_188873 crossref_primary_10_1096_fj_202500022R crossref_primary_10_3390_vaccines11020239 crossref_primary_10_1016_j_phymed_2022_154137 crossref_primary_10_3390_ijms25179245 crossref_primary_10_1097_SLA_0000000000006050 crossref_primary_10_1186_s13027_023_00521_y crossref_primary_10_1016_j_jbo_2025_100689 crossref_primary_10_1016_j_lungcan_2023_107263 crossref_primary_10_3390_cancers15072010 crossref_primary_10_2217_fon_2020_0362 crossref_primary_10_3390_ijms21103452 crossref_primary_10_7554_eLife_95106 crossref_primary_10_1002_iid3_523 crossref_primary_10_1186_s40364_025_00783_1 crossref_primary_10_2217_fon_2020_1218 crossref_primary_10_3390_cells11152340 crossref_primary_10_1158_0008_5472_CAN_20_3337 crossref_primary_10_1186_s43067_024_00150_4 crossref_primary_10_3390_cells10092245 crossref_primary_10_3390_cells10092486 crossref_primary_10_3389_fgene_2021_730920 crossref_primary_10_1186_s12967_023_03943_9 crossref_primary_10_3390_fractalfract8070394 crossref_primary_10_1007_s11033_023_08852_0 crossref_primary_10_3390_foods10061268 crossref_primary_10_3390_pharmaceutics15112622 crossref_primary_10_1002_tox_24011 crossref_primary_10_3390_molecules26041162 crossref_primary_10_1007_s12672_025_02629_6 crossref_primary_10_1038_s41420_023_01337_w crossref_primary_10_1177_2399369320953869 crossref_primary_10_1016_j_jconrel_2020_04_023 crossref_primary_10_1002_path_6377 crossref_primary_10_1080_17474086_2020_1755958 crossref_primary_10_1186_s12943_024_01990_4 crossref_primary_10_3389_fimmu_2020_595835 crossref_primary_10_1016_S1470_2045_20_30324_7 crossref_primary_10_1039_D2FO01720B crossref_primary_10_3390_ijms26136388 crossref_primary_10_1186_s13046_023_02620_5 crossref_primary_10_1109_TVCG_2022_3209378 crossref_primary_10_1007_s00210_023_02781_2 crossref_primary_10_1007_s11033_022_07706_5 crossref_primary_10_1038_s41598_023_38822_2 crossref_primary_10_1177_15330338221085360 crossref_primary_10_1016_j_oor_2024_100500 crossref_primary_10_1016_j_cyto_2024_156730 crossref_primary_10_1128_spectrum_02792_24 crossref_primary_10_3390_cells13181518 crossref_primary_10_3390_ijms25179463 crossref_primary_10_1016_j_actbio_2022_08_005 crossref_primary_10_1016_j_prp_2025_155981 crossref_primary_10_1140_epje_s10189_025_00517_z crossref_primary_10_2174_1574893618666230502102712 crossref_primary_10_3389_fcell_2023_1187989 crossref_primary_10_3390_genes16040437 crossref_primary_10_1007_s10911_021_09495_2 crossref_primary_10_1038_s41388_019_1088_8 crossref_primary_10_1073_pnas_2102718118 crossref_primary_10_1080_2162402X_2021_1964189 crossref_primary_10_3390_jcm9103248 crossref_primary_10_1177_2399369320972122 crossref_primary_10_1002_mma_70115 crossref_primary_10_1186_s12951_023_01909_z crossref_primary_10_3389_fimmu_2024_1497522 crossref_primary_10_3390_ijms19123959 crossref_primary_10_1016_j_omto_2021_08_008 crossref_primary_10_1016_j_semcancer_2020_02_008 crossref_primary_10_1016_j_intimp_2023_111055 crossref_primary_10_1186_s13072_024_00525_x crossref_primary_10_3389_fimmu_2024_1326753 crossref_primary_10_1063_5_0129602 crossref_primary_10_1177_03946320231178769 crossref_primary_10_1016_j_jconrel_2022_09_066 crossref_primary_10_3389_fimmu_2019_02716 crossref_primary_10_7759_cureus_66521 crossref_primary_10_1083_jcb_202403096 crossref_primary_10_3389_fbioe_2021_771153 crossref_primary_10_3389_fimmu_2022_864739 crossref_primary_10_3389_fimmu_2021_690499 crossref_primary_10_1097_MCP_0000000000001163 crossref_primary_10_3390_biom15060828 crossref_primary_10_3390_ijms22189794 crossref_primary_10_2174_0109298673320179240803071001 crossref_primary_10_1177_20503121211069012 crossref_primary_10_2147_JIR_S392082 crossref_primary_10_3390_v13040654 crossref_primary_10_1016_j_addr_2022_114239 crossref_primary_10_1007_s11538_021_00933_0 crossref_primary_10_3390_ijms22189791 crossref_primary_10_1093_stcltm_szab029 crossref_primary_10_1055_a_2008_7732 crossref_primary_10_1080_13880209_2024_2349042 crossref_primary_10_1038_s41421_021_00312_y crossref_primary_10_3390_ijerph17217995 crossref_primary_10_3389_fonc_2022_1004871 crossref_primary_10_1038_s41416_023_02379_8 crossref_primary_10_3892_ijo_2023_5572 crossref_primary_10_1038_s41417_022_00582_y crossref_primary_10_1038_s41416_019_0717_x crossref_primary_10_1038_s41598_023_46476_3 crossref_primary_10_1016_j_jddst_2023_105040 crossref_primary_10_3390_cancers14040976 crossref_primary_10_3390_genes14040798 crossref_primary_10_1158_1078_0432_CCR_21_0163 crossref_primary_10_1016_j_biopha_2025_118308 crossref_primary_10_1186_s12876_022_02510_8 crossref_primary_10_3389_fimmu_2020_603341 crossref_primary_10_1016_j_neo_2024_101100 crossref_primary_10_35516_jjps_v18i2_2989 crossref_primary_10_3389_fgene_2022_912190 crossref_primary_10_1016_j_critrevonc_2021_103541 crossref_primary_10_3390_v17070885 crossref_primary_10_3390_cancers12082237 crossref_primary_10_1038_s41416_021_01330_z crossref_primary_10_1080_01621459_2024_2408777 crossref_primary_10_1158_0008_5472_CAN_23_2957 crossref_primary_10_1016_j_phrs_2023_106756 crossref_primary_10_31083_j_ceog4902035 crossref_primary_10_59717_j_xinn_life_2023_100014 crossref_primary_10_1007_s10238_023_01230_x crossref_primary_10_3389_fendo_2024_1358416 crossref_primary_10_3390_ijms24054922 crossref_primary_10_2147_OTT_S263998 crossref_primary_10_1186_s13046_023_02786_y crossref_primary_10_3390_cells10113097 crossref_primary_10_1186_s12885_023_11691_8 crossref_primary_10_2147_OTT_S293148 crossref_primary_10_1038_s41571_019_0266_5 crossref_primary_10_1001_jamanetworkopen_2019_16526 crossref_primary_10_1007_s13555_023_00905_3 crossref_primary_10_1182_bloodadvances_2022008722 crossref_primary_10_1186_s12935_022_02769_7 crossref_primary_10_1007_s11033_025_10626_9 crossref_primary_10_3390_ph13110389 crossref_primary_10_3897_pharmacia_71_e114556 crossref_primary_10_3390_jcm9123912 crossref_primary_10_3389_fmolb_2022_888020 crossref_primary_10_3390_jcm10112243 crossref_primary_10_3390_ijms241713269 crossref_primary_10_1016_j_chempr_2023_12_020 crossref_primary_10_1002_eji_202250036 crossref_primary_10_1109_ACCESS_2021_3123569 crossref_primary_10_3389_fmolb_2022_823911 crossref_primary_10_1002_smsc_202400248 crossref_primary_10_1016_j_jtocrr_2025_100845 crossref_primary_10_1007_s00285_022_01851_y crossref_primary_10_3390_ijms24076709 crossref_primary_10_1038_s43018_022_00480_0 crossref_primary_10_1097_MD_0000000000041273 crossref_primary_10_1186_s12935_021_02396_8 crossref_primary_10_1158_0008_5472_CAN_24_3686 crossref_primary_10_1007_s10142_024_01445_5 crossref_primary_10_1016_j_canlet_2019_10_020 crossref_primary_10_1016_j_bbcan_2024_189164 crossref_primary_10_1016_j_ymthe_2020_12_032 crossref_primary_10_1038_s41388_023_02669_8 crossref_primary_10_1016_j_canlet_2024_217241 crossref_primary_10_1126_science_aay9040 crossref_primary_10_62347_EANH4082 crossref_primary_10_3389_fimmu_2023_1298891 crossref_primary_10_1016_j_critrevonc_2023_103919 crossref_primary_10_1155_bmri_5086946 crossref_primary_10_2147_CMAR_S523419 crossref_primary_10_3390_cancers16162820 crossref_primary_10_3390_plants10122749 crossref_primary_10_1186_s12943_023_01818_7 crossref_primary_10_3390_diagnostics11071298 crossref_primary_10_3389_fimmu_2024_1373738 crossref_primary_10_3390_ijms21010170 crossref_primary_10_1088_1758_5090_adb51c crossref_primary_10_1097_MD_0000000000043218 crossref_primary_10_1186_s12935_025_03817_8 crossref_primary_10_3390_ijms24087604 crossref_primary_10_3390_ijms22126385 crossref_primary_10_1097_JN9_0000000000000049 crossref_primary_10_1007_s00285_025_02253_6 crossref_primary_10_3389_fimmu_2024_1487782 crossref_primary_10_1016_j_prostaglandins_2025_107028 crossref_primary_10_1038_s41467_022_35345_8 crossref_primary_10_1002_adbi_202400735 crossref_primary_10_3389_fimmu_2021_751594 crossref_primary_10_31083_j_fbl2910349 crossref_primary_10_1016_j_canlet_2024_216766 crossref_primary_10_1016_j_critrevonc_2024_104437 crossref_primary_10_1016_j_lfs_2021_119750 crossref_primary_10_1002_mef2_23 crossref_primary_10_1089_omi_2019_0093 crossref_primary_10_1016_j_biopha_2024_116207 crossref_primary_10_3389_fimmu_2022_831636 crossref_primary_10_1016_j_neuron_2022_03_027 crossref_primary_10_1245_s10434_022_12578_x crossref_primary_10_1146_annurev_animal_020420_033029 crossref_primary_10_3390_cancers13184543 crossref_primary_10_1186_s13058_021_01403_0 crossref_primary_10_1038_s41467_025_61685_2 crossref_primary_10_3390_cancers13153801 crossref_primary_10_1038_s41420_022_01059_5 crossref_primary_10_1242_dmm_050770 crossref_primary_10_3390_ijms242216292 crossref_primary_10_3390_nano10122453 crossref_primary_10_1007_s12013_022_01120_1 crossref_primary_10_3390_jcm13216537 crossref_primary_10_3389_fonc_2022_871085 crossref_primary_10_1016_j_socscimed_2023_116448 crossref_primary_10_1016_j_tranon_2020_100932 crossref_primary_10_1182_bloodadvances_2024014008 crossref_primary_10_1002_ctm2_730 crossref_primary_10_3389_fmolb_2022_962743 crossref_primary_10_3389_fonc_2025_1622008 crossref_primary_10_1016_j_ccell_2019_06_009 crossref_primary_10_3389_fimmu_2024_1282680 crossref_primary_10_1007_s40801_023_00399_7 crossref_primary_10_1038_s43018_023_00695_9 crossref_primary_10_1016_j_biopha_2024_117750 crossref_primary_10_1016_j_actbio_2020_02_006 crossref_primary_10_1155_2022_6100187 crossref_primary_10_52679_tabcj_2025_62002 crossref_primary_10_3390_ijms22136833 crossref_primary_10_1016_j_heliyon_2023_e23521 crossref_primary_10_1016_j_jbi_2023_104373 crossref_primary_10_3389_fonc_2021_591386 crossref_primary_10_3389_fonc_2022_885236 crossref_primary_10_1002_cam4_4341 crossref_primary_10_3390_cancers11121920 crossref_primary_10_1016_j_jshs_2024_100994 crossref_primary_10_1007_s12029_021_00769_w crossref_primary_10_1016_j_molimm_2024_11_009 crossref_primary_10_1007_s10555_021_09957_3 crossref_primary_10_1002_adhm_202001853 crossref_primary_10_1016_j_critrevonc_2025_104707 crossref_primary_10_3390_cancers12010150 crossref_primary_10_1136_ijgc_2022_003345 crossref_primary_10_3389_fmars_2020_614766 crossref_primary_10_3390_ijms241411673 crossref_primary_10_1016_j_bbadis_2024_167164 crossref_primary_10_3390_ph16121652 crossref_primary_10_3389_fcell_2022_816517 crossref_primary_10_1111_jcmm_70146 crossref_primary_10_1016_j_tox_2021_152994 crossref_primary_10_1016_j_jbc_2022_102106 crossref_primary_10_3390_cancers12082205 crossref_primary_10_3390_cells13231937 crossref_primary_10_1016_j_ecolmodel_2025_111326 crossref_primary_10_1016_j_cyto_2022_155948 crossref_primary_10_3390_biomedicines10051181 crossref_primary_10_3390_md22100462 crossref_primary_10_1016_j_jtbi_2023_111577 crossref_primary_10_1111_acel_13309 crossref_primary_10_1002_cnr2_1802 crossref_primary_10_1038_s41568_021_00347_z crossref_primary_10_3389_fcell_2020_607670 crossref_primary_10_3390_nu14224787 crossref_primary_10_1002_advs_202309348 crossref_primary_10_1038_s43587_025_00827_z crossref_primary_10_1111_jop_13568 crossref_primary_10_1186_s41065_021_00203_y crossref_primary_10_1186_s43046_025_00287_x crossref_primary_10_1111_febs_17034 crossref_primary_10_1159_000507581 crossref_primary_10_1002_cac2_12068 crossref_primary_10_3390_cancers16081508 crossref_primary_10_1080_01443615_2025_2541610 crossref_primary_10_1007_s12020_025_04212_z crossref_primary_10_1016_j_mtbio_2025_101716 crossref_primary_10_1038_s41467_021_23330_6 crossref_primary_10_1080_13102818_2022_2041485 crossref_primary_10_3390_cancers15245857 crossref_primary_10_3390_jpm11020149 crossref_primary_10_1007_s11701_024_01861_6 crossref_primary_10_1007_s12032_023_02010_z crossref_primary_10_3389_fonc_2022_799185 crossref_primary_10_1016_j_tig_2020_07_004 crossref_primary_10_3390_cancers14092339 crossref_primary_10_1155_2021_9250207 crossref_primary_10_3390_cancers17050817 crossref_primary_10_3390_ijms21155521 crossref_primary_10_3389_fonc_2022_862337 crossref_primary_10_3389_fonc_2022_903806 crossref_primary_10_2217_fmb_2020_0245 crossref_primary_10_3389_fimmu_2021_752888 crossref_primary_10_1111_sji_12999 crossref_primary_10_1016_j_prp_2023_154735 crossref_primary_10_3390_cancers12071748 crossref_primary_10_1016_j_clnu_2024_04_012 crossref_primary_10_3390_foods10040752 crossref_primary_10_3390_ijms241612931 crossref_primary_10_1038_s41598_024_62738_0 crossref_primary_10_3390_microbiolres14030059 crossref_primary_10_1038_s41467_024_48347_5 crossref_primary_10_1016_j_joms_2024_03_022 crossref_primary_10_3390_pharmaceutics15082022 crossref_primary_10_3389_fonc_2020_627701 crossref_primary_10_3390_md21050266 crossref_primary_10_2147_CMAR_S336268 crossref_primary_10_3389_fimmu_2024_1355945 crossref_primary_10_1126_scitranslmed_abf5473 crossref_primary_10_3389_fimmu_2021_633205 crossref_primary_10_2147_CMAR_S287152 crossref_primary_10_1097_TP_0000000000003851 crossref_primary_10_3390_cancers12071755 crossref_primary_10_1016_j_isci_2024_110632 crossref_primary_10_1007_s11912_021_01125_8 crossref_primary_10_1038_s41588_025_02086_5 crossref_primary_10_1136_jitc_2021_003416 crossref_primary_10_2147_IJN_S413831 crossref_primary_10_3390_cancers14092314 crossref_primary_10_3390_biology13050307 crossref_primary_10_1007_s12020_019_02145_y crossref_primary_10_1016_j_urolonc_2024_03_018 crossref_primary_10_1016_j_ccell_2021_01_017 crossref_primary_10_3389_fonc_2019_00739 crossref_primary_10_1038_s41378_023_00616_x crossref_primary_10_3389_fonc_2020_00423 crossref_primary_10_3390_cancers11121961 crossref_primary_10_1007_s12602_024_10288_2 crossref_primary_10_3390_biology12050694 crossref_primary_10_1007_s10856_021_06526_6 crossref_primary_10_1016_j_canlet_2021_10_012 crossref_primary_10_1016_j_omto_2022_02_019 crossref_primary_10_1007_s40883_024_00338_0 crossref_primary_10_1080_10408363_2022_2038539 crossref_primary_10_3390_cells13040361 crossref_primary_10_2217_imt_2021_0070 crossref_primary_10_3390_molecules26133952 crossref_primary_10_1016_j_xphs_2022_05_008 crossref_primary_10_1038_s41388_024_03104_2 crossref_primary_10_1016_j_critrevonc_2024_104465 crossref_primary_10_1186_s13058_022_01568_2 crossref_primary_10_1155_2019_7286737 crossref_primary_10_3390_medicina58121755 crossref_primary_10_1038_s41585_023_00827_x crossref_primary_10_2147_JIR_S340477 crossref_primary_10_15252_embj_2021108647 crossref_primary_10_3390_jcm10040893 crossref_primary_10_1007_s10555_020_09871_0 crossref_primary_10_3390_mi13122217 crossref_primary_10_3390_cancers12103071 crossref_primary_10_3389_fimmu_2021_679425 crossref_primary_10_3390_cells11233818 crossref_primary_10_1016_j_jddst_2024_106007 crossref_primary_10_1016_j_ctrv_2020_102089 crossref_primary_10_3390_cancers12041047 crossref_primary_10_1136_jitc_2022_004688 crossref_primary_10_1242_dmm_048977 crossref_primary_10_1097_GOX_0000000000006317 crossref_primary_10_1158_2767_9764_CRC_24_0257 crossref_primary_10_14712_fb2023069020059 crossref_primary_10_3389_fphar_2024_1410453 crossref_primary_10_1002_cam4_3754 crossref_primary_10_3390_cancers14112629 crossref_primary_10_3390_cells10102672 crossref_primary_10_1186_s12943_019_1102_3 crossref_primary_10_1016_j_cellsig_2021_110075 crossref_primary_10_3390_pharmaceutics12121186 crossref_primary_10_1089_dna_2021_1118 crossref_primary_10_3390_ijms26125911 crossref_primary_10_1186_s12859_021_04526_5 crossref_primary_10_3390_life13051097 crossref_primary_10_1080_21655979_2021_1955558 crossref_primary_10_3389_fcell_2021_720494 crossref_primary_10_3390_ijms222112015 crossref_primary_10_1007_s00262_022_03337_8 crossref_primary_10_3390_pharmaceutics14122686 crossref_primary_10_1093_oxfimm_iqaf005 crossref_primary_10_3390_ijms252011045 crossref_primary_10_1016_j_pathol_2024_11_004 crossref_primary_10_3389_fnut_2022_945833 crossref_primary_10_3390_ijms232416190 crossref_primary_10_1016_j_jconrel_2021_10_010 crossref_primary_10_3389_fimmu_2023_1189323 crossref_primary_10_3390_microorganisms9061262 crossref_primary_10_1093_jscr_rjad223 crossref_primary_10_1016_j_addr_2020_09_001 crossref_primary_10_1007_s12032_024_02435_0 crossref_primary_10_3390_vaccines11040770 crossref_primary_10_1142_S0192415X21500117 crossref_primary_10_4103_jcrt_jcrt_1950_23 crossref_primary_10_1158_0008_5472_CAN_22_2217 crossref_primary_10_1007_s00432_020_03424_2 crossref_primary_10_3389_fonc_2020_573399 crossref_primary_10_3390_cancers14122890 crossref_primary_10_3390_cells12030491 crossref_primary_10_3390_antiox9111109 crossref_primary_10_3389_fsurg_2022_917061 crossref_primary_10_1016_j_apm_2022_05_038 crossref_primary_10_1038_s42003_021_02825_4 crossref_primary_10_1016_j_cellsig_2022_110371 crossref_primary_10_3390_jpm12040534 crossref_primary_10_1007_s11095_021_03143_4 crossref_primary_10_2147_IJN_S496664 crossref_primary_10_1007_s12032_024_02337_1 crossref_primary_10_3390_pharmaceutics14051068 crossref_primary_10_1007_s00285_021_01673_4 crossref_primary_10_1080_07391102_2024_2329302 crossref_primary_10_1016_j_ctrv_2021_102157 crossref_primary_10_1007_s40435_024_01474_9 crossref_primary_10_1002_advs_202204487 crossref_primary_10_1038_s41588_025_02077_6 crossref_primary_10_1016_j_nucmedbio_2024_108917 crossref_primary_10_1134_S1560354724050010 crossref_primary_10_3389_fonc_2021_780744 crossref_primary_10_4103_jimr_jimr_28_23 crossref_primary_10_4103_NRR_NRR_D_24_00901 crossref_primary_10_5937_arhfarm1906490F crossref_primary_10_3390_jcm13247597 crossref_primary_10_3389_fimmu_2022_740588 crossref_primary_10_1016_j_ijrobp_2022_04_015 crossref_primary_10_1016_j_semcancer_2025_06_005 crossref_primary_10_3389_fonc_2022_1009881 crossref_primary_10_3389_fimmu_2022_1022190 crossref_primary_10_3389_fsens_2022_789771 crossref_primary_10_3389_fimmu_2024_1493978 crossref_primary_10_3389_fimmu_2022_995715 crossref_primary_10_3390_life12111807 crossref_primary_10_1007_s10549_025_07772_w crossref_primary_10_1007_s00262_021_02857_z crossref_primary_10_1007_s11307_021_01686_x crossref_primary_10_32604_or_2024_047933 crossref_primary_10_3390_ijms23116215 crossref_primary_10_37349_etat_2025_1002313 crossref_primary_10_3390_ijms222312739 crossref_primary_10_1007_s12539_024_00657_4 crossref_primary_10_3390_ijms25084561 crossref_primary_10_37349_emed_2025_1001314 crossref_primary_10_1089_ten_teb_2019_0302 crossref_primary_10_3390_cancers13164226 crossref_primary_10_1155_2022_1831211 crossref_primary_10_3390_cancers14143331 crossref_primary_10_1007_s00423_022_02432_9 crossref_primary_10_1080_10717544_2022_2161670 crossref_primary_10_1111_1440_1681_13875 crossref_primary_10_1136_bcr_2020_238037 crossref_primary_10_2217_fon_2023_0695 crossref_primary_10_3390_ijms25084314 crossref_primary_10_3389_fimmu_2024_1501009 crossref_primary_10_1186_s13058_025_01997_9 crossref_primary_10_1016_j_omto_2022_05_013 crossref_primary_10_3390_cancers11071008 crossref_primary_10_3390_vaccines10050816 crossref_primary_10_1038_s41568_021_00395_5 crossref_primary_10_1038_s41568_022_00544_4 crossref_primary_10_1016_j_bbcan_2020_188499 crossref_primary_10_1136_jitc_2024_010419 crossref_primary_10_3389_fmed_2024_1381492 crossref_primary_10_1038_s41598_024_68048_9 crossref_primary_10_3390_cancers12020392 crossref_primary_10_1155_2020_5494858 crossref_primary_10_1038_s41467_020_18125_0 crossref_primary_10_1515_ntrev_2025_0167 crossref_primary_10_3390_jpm13060968 crossref_primary_10_3390_vaccines10122018 crossref_primary_10_1186_s12964_024_01622_w crossref_primary_10_3390_cimb47010002 crossref_primary_10_4103_jcrt_JCRT_1685_20 crossref_primary_10_1038_s41467_023_36310_9 crossref_primary_10_3390_diagnostics15111437 crossref_primary_10_1007_s12026_024_09546_w crossref_primary_10_1177_15330338211036304 crossref_primary_10_1007_s12672_025_02775_x crossref_primary_10_1007_s12272_023_01473_y crossref_primary_10_1016_j_ijbiomac_2023_123670 crossref_primary_10_1161_STROKEAHA_119_027085 crossref_primary_10_1186_s40364_022_00399_9 crossref_primary_10_3390_cancers15082323 crossref_primary_10_2217_bmm_2023_0212 crossref_primary_10_1016_j_cell_2020_10_045 crossref_primary_10_3389_fimmu_2025_1529707 crossref_primary_10_1039_C9FO00865A crossref_primary_10_1186_s40478_023_01542_9 crossref_primary_10_1089_cell_2022_0047 crossref_primary_10_3389_fimmu_2023_1196033 crossref_primary_10_1245_s10434_023_14176_x crossref_primary_10_1016_j_ejphar_2022_175410 crossref_primary_10_1016_j_jconrel_2022_04_007 crossref_primary_10_2217_mmt_2020_0006 crossref_primary_10_1371_journal_pone_0298775 crossref_primary_10_1667_RADE_23_00050_1 crossref_primary_10_3390_cancers14215406 crossref_primary_10_3390_genes16080861 crossref_primary_10_3390_ijms242015332 crossref_primary_10_3389_fonc_2020_01109 crossref_primary_10_3389_fmicb_2021_624618 crossref_primary_10_1007_s00432_023_04737_8 crossref_primary_10_1016_j_lfs_2024_122652 crossref_primary_10_3390_genes13061017 crossref_primary_10_2147_OTT_S483753 crossref_primary_10_3390_cancers12020371 crossref_primary_10_1002_ijc_35338 crossref_primary_10_1126_science_add5327 crossref_primary_10_1002_adtp_202000186 crossref_primary_10_1080_2162402X_2023_2230666 crossref_primary_10_1016_S2468_1253_22_00235_7 crossref_primary_10_3389_fgene_2020_00314 crossref_primary_10_3389_fgene_2023_1112744 crossref_primary_10_1007_s00285_024_02123_7 crossref_primary_10_1111_imcb_12658 crossref_primary_10_3389_fonc_2022_840038 crossref_primary_10_1007_s00381_024_06461_1 crossref_primary_10_3389_fonc_2020_01101 crossref_primary_10_1016_j_oraloncology_2025_107417 crossref_primary_10_1186_s40164_022_00349_z crossref_primary_10_3389_fonc_2021_770500 crossref_primary_10_1111_imm_13300 crossref_primary_10_3389_fimmu_2022_997765 crossref_primary_10_3390_ijms26125524 crossref_primary_10_1016_j_vaccine_2024_126690 crossref_primary_10_1038_s41419_023_06230_z crossref_primary_10_1007_s11538_022_01054_y crossref_primary_10_3389_fgene_2023_1230998 crossref_primary_10_1038_s41416_020_0985_5 crossref_primary_10_1038_s41388_022_02525_1 crossref_primary_10_1093_oncolo_oyac128 crossref_primary_10_1007_s10585_024_10292_4 crossref_primary_10_1093_trstmh_trac015 crossref_primary_10_1007_s00405_022_07804_x crossref_primary_10_3390_ijms241914542 crossref_primary_10_3389_fimmu_2021_609762 crossref_primary_10_3389_fonc_2020_588221 crossref_primary_10_3389_fimmu_2021_662528 crossref_primary_10_3389_fonc_2020_607622 crossref_primary_10_1186_s12885_024_13044_5 crossref_primary_10_1002_mabi_202100272 crossref_primary_10_1016_j_heliyon_2024_e34046 crossref_primary_10_3390_ijms22147514 crossref_primary_10_3390_cancers15030702 crossref_primary_10_1016_j_jid_2021_11_013 crossref_primary_10_1016_j_bcp_2021_114803 crossref_primary_10_3390_biomedicines12040920 crossref_primary_10_3389_fendo_2022_1031210 crossref_primary_10_1021_jacs_9b07171 crossref_primary_10_3390_bioengineering9070280 crossref_primary_10_1007_s11426_020_9943_9 crossref_primary_10_1016_j_ejpb_2025_114675 crossref_primary_10_1002_jso_27748 crossref_primary_10_2147_CMAR_S366738 crossref_primary_10_1016_j_jtho_2023_11_017 crossref_primary_10_1016_j_phrs_2020_105111 crossref_primary_10_3389_fgene_2022_818994 crossref_primary_10_32604_biocell_2024_047965 crossref_primary_10_3390_ijms26104821 crossref_primary_10_3390_cells10092387 crossref_primary_10_1016_j_chembiol_2024_10_013 crossref_primary_10_1016_j_isci_2025_111765 crossref_primary_10_2147_OTT_S402389 crossref_primary_10_1038_s41419_023_06021_6 crossref_primary_10_3389_fimmu_2023_1235483 crossref_primary_10_3389_fphar_2022_922457 crossref_primary_10_1016_S2468_2667_23_00182_2 crossref_primary_10_3389_fendo_2024_1293842 crossref_primary_10_3233_BD_230047 crossref_primary_10_3389_fonc_2021_654922 crossref_primary_10_3390_molecules26051343 crossref_primary_10_1016_j_adcanc_2023_100107 crossref_primary_10_3390_cancers16172942 crossref_primary_10_71336_jabs_1009 crossref_primary_10_1007_s10439_019_02384_0 crossref_primary_10_3390_cancers13133179 crossref_primary_10_3389_fonc_2025_1404695 crossref_primary_10_1016_j_chaos_2024_115971 crossref_primary_10_3389_fonc_2024_1322897 crossref_primary_10_1016_j_mrfmmm_2024_111896 crossref_primary_10_52711_0974_360X_2025_00348 crossref_primary_10_2174_0115665232340926241105064739 crossref_primary_10_1016_j_heliyon_2023_e13048 crossref_primary_10_1016_j_intimp_2023_110015 crossref_primary_10_3390_cells10040927 crossref_primary_10_1038_s41571_020_0403_1 crossref_primary_10_1186_s12964_025_02139_6 crossref_primary_10_1007_s11538_024_01400_2 crossref_primary_10_1038_s41598_024_60347_5 crossref_primary_10_1177_15353702221121631 crossref_primary_10_1039_D4BM00995A crossref_primary_10_1007_s00262_022_03333_y crossref_primary_10_3389_fimmu_2023_1211064 crossref_primary_10_1007_s10911_025_09578_4 crossref_primary_10_1136_jitc_2023_007624 crossref_primary_10_26508_lsa_202000935 crossref_primary_10_1080_08977194_2022_2087520 crossref_primary_10_1136_jitc_2023_007625 crossref_primary_10_1016_j_biomaterials_2021_120654 crossref_primary_10_7759_cureus_48941 crossref_primary_10_3390_genes10110915 crossref_primary_10_1016_j_bbcan_2021_188585 crossref_primary_10_1038_s41392_023_01608_z crossref_primary_10_3389_fonc_2024_1435480 crossref_primary_10_1016_j_bbcan_2021_188587 crossref_primary_10_1080_10409238_2022_2088684 crossref_primary_10_1016_j_ctrv_2024_102845 crossref_primary_10_1186_s12957_022_02646_7 crossref_primary_10_3390_cancers14164032 crossref_primary_10_1016_j_mbs_2022_108868 crossref_primary_10_1111_1754_9485_13399 crossref_primary_10_3389_fonc_2024_1331355 crossref_primary_10_31083_j_fbl2909312 crossref_primary_10_1016_j_bbadis_2022_166565 crossref_primary_10_1016_j_oraloncology_2020_105084 crossref_primary_10_1080_1120009X_2023_2300224 crossref_primary_10_3389_fonc_2019_01004 crossref_primary_10_3389_fonc_2024_1380527 crossref_primary_10_3390_bioengineering11080830 crossref_primary_10_1007_s12032_023_02201_8 crossref_primary_10_1039_D0BM01943G crossref_primary_10_1002_advs_202304160 crossref_primary_10_3390_cancers16172927 crossref_primary_10_4251_wjgo_v15_i8_1349 crossref_primary_10_1016_j_semcancer_2020_06_010 crossref_primary_10_3390_cancers17071232 crossref_primary_10_1007_s12602_025_10741_w crossref_primary_10_1186_s12964_020_00596_9 crossref_primary_10_1038_s41598_024_80280_x crossref_primary_10_3390_biomedicines10092142 crossref_primary_10_3390_pharmaceutics13010103 crossref_primary_10_1038_s41423_020_0470_3 crossref_primary_10_3892_ol_2021_13046 crossref_primary_10_3390_cancers12123558 crossref_primary_10_1038_s42003_023_05756_4 crossref_primary_10_3389_fonc_2022_877147 crossref_primary_10_1080_2162402X_2022_2060907 crossref_primary_10_3389_fonc_2023_1292046 crossref_primary_10_1007_s10120_023_01426_w crossref_primary_10_1038_s41467_021_27088_9 crossref_primary_10_3389_fimmu_2022_964898 crossref_primary_10_3389_fcell_2020_598205 crossref_primary_10_3390_molecules29143252 crossref_primary_10_1016_j_semcancer_2023_02_008 crossref_primary_10_3390_cancers17172900 crossref_primary_10_1177_10732748241264704 crossref_primary_10_2147_JHC_S450825 crossref_primary_10_1016_j_copbio_2024_103169 crossref_primary_10_1002_jcla_24585 crossref_primary_10_1186_s13058_025_01982_2 crossref_primary_10_1038_s41467_021_22890_x crossref_primary_10_1016_j_jconrel_2024_05_030 crossref_primary_10_1016_j_jbc_2021_100523 crossref_primary_10_1111_febs_16563 crossref_primary_10_1038_s41598_024_74985_2 crossref_primary_10_1136_ijgc_2023_004360 crossref_primary_10_1177_15593258221076711 crossref_primary_10_1016_j_ijpx_2025_100384 crossref_primary_10_1186_s12885_022_10404_x crossref_primary_10_1186_s12885_025_14458_5 crossref_primary_10_1186_s12967_023_03924_y crossref_primary_10_3389_fcell_2022_913684 crossref_primary_10_3390_ijms21218363 crossref_primary_10_1016_j_taap_2022_116248 crossref_primary_10_3390_cells11121974 crossref_primary_10_1038_s41585_025_01031_9 crossref_primary_10_1002_path_6238 crossref_primary_10_1002_jso_27319 crossref_primary_10_1111_cns_70013 crossref_primary_10_1002_1878_0261_13302 crossref_primary_10_1038_s41420_025_02407_x crossref_primary_10_3389_fnut_2022_898417 crossref_primary_10_3389_fonc_2021_731323 crossref_primary_10_3390_cancers14102408 crossref_primary_10_3390_cancers13040599 crossref_primary_10_3389_fimmu_2021_672356 crossref_primary_10_3390_bioengineering10101187 crossref_primary_10_3390_cancers16132478 crossref_primary_10_1016_j_bja_2023_07_027 crossref_primary_10_3389_fimmu_2023_1145552 crossref_primary_10_1172_JCI143762 crossref_primary_10_1016_j_ijpharm_2021_120712 crossref_primary_10_1063_5_0210955 crossref_primary_10_3389_fonc_2021_692142 crossref_primary_10_1186_s12920_021_00883_5 crossref_primary_10_1002_ijc_35179 crossref_primary_10_1002_icd_2497 crossref_primary_10_1016_j_currproblcancer_2022_100848 crossref_primary_10_3390_cancers14112675 crossref_primary_10_3390_ijms22158234 crossref_primary_10_1186_s13000_024_01454_9
ContentType	Journal Article
Copyright	2018 Gonzalez et al.; Published by Cold Spring Harbor Laboratory Press.
Copyright_xml	– notice: 2018 Gonzalez et al.; Published by Cold Spring Harbor Laboratory Press.
DBID	CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1101/gad.314617.118
DatabaseName	Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE - Academic MEDLINE
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	no_fulltext_linktorsrc
Discipline	Biology
EISSN	1549-5477
ExternalDocumentID	30275043
Genre	Review Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural
GrantInformation_xml	– fundername: NCI NIH HHS grantid: R01 CA057621 – fundername: NCI NIH HHS grantid: U01 CA199315 – fundername: NCI NIH HHS grantid: R01 CA190851
GroupedDBID	--- -DZ -~X .55 18M 29H 2WC 39C 4.4 53G 5RE 5VS 85S ABCQX ABDIX ACGFO ACNCT ADBBV ADIYS AECCQ AENEX AFFNX AFOSN AHPUY ALMA_UNASSIGNED_HOLDINGS BAWUL BTFSW CGR CS3 CUY CVF DIK DU5 E3Z EBS ECM EIF EJD F5P FRP GX1 H13 HYE H~9 IH2 KQ8 L7B MV1 N9A NPM OK1 P2P R.V RCX RHF RHI RPM SJN TAE TN5 TR2 UHB VQA W8F WH7 WOQ X7M XSW YBU YHG YKV YSK 7X8 ACLKE ADXHL AETEA
ID	FETCH-LOGICAL-c483t-e272c391f02d73be3bab61eb0b6773a687ab6a11e5846313f3ffb6c90a1c5e42
IEDL.DBID	7X8
ISICitedReferencesCount	1546
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000447716700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	1549-5477
IngestDate	Sun Aug 24 04:13:01 EDT 2025 Wed Feb 19 02:30:38 EST 2025
IsDoiOpenAccess	false
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	19-20
Keywords	disseminated tumor cells immune cross-talk patient-derived xenograft cancer heterogeneity metastasis-associated immune cells tumor-associated macrophages
Language	English
License	2018 Gonzalez et al.; Published by Cold Spring Harbor Laboratory Press.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c483t-e272c391f02d73be3bab61eb0b6773a687ab6a11e5846313f3ffb6c90a1c5e42
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ORCID	0000-0002-6525-3872
OpenAccessLink	https://www.osti.gov/servlets/purl/1560566
PMID	30275043
PQID	2115756878
PQPubID	23479
ParticipantIDs	proquest_miscellaneous_2115756878 pubmed_primary_30275043
PublicationCentury	2000
PublicationDate	2018-10-01
PublicationDateYYYYMMDD	2018-10-01
PublicationDate_xml	– month: 10 year: 2018 text: 2018-10-01 day: 01
PublicationDecade	2010
PublicationPlace	United States
PublicationPlace_xml	– name: United States
PublicationTitle	Genes & development
PublicationTitleAlternate	Genes Dev
PublicationYear	2018
SSID	ssj0006066
Score	2.721506
SecondaryResourceType	review_article
Snippet	The presence of inflammatory immune cells in human tumors raises a fundamental question in oncology: How do cancer cells avoid the destruction by immune...
SourceID	proquest pubmed
SourceType	Aggregation Database Index Database
StartPage	1267
SubjectTerms	B-Lymphocytes - immunology Carcinoma - immunology Carcinoma - secondary Dendritic Cells - immunology Disease Progression Humans Immunologic Surveillance Inflammation - immunology Killer Cells, Natural - immunology Macrophages - immunology Neoplasm Metastasis - immunology Neoplasms - immunology Neutrophils - immunology T-Lymphocytes - immunology
Title	Roles of the immune system in cancer: from tumor initiation to metastatic progression
URI	https://www.ncbi.nlm.nih.gov/pubmed/30275043 https://www.proquest.com/docview/2115756878
Volume	32
WOSCitedRecordID	wos000447716700001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText
inHoldings	1
isFullTextHit
isPrint
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NS8MwFA_qFLz4_TG_iOA1rEnaJvUiIg4vjiETdhtJmkgPa-fWCf73vjQdOwmCl0AChebll-SXvLzfQ-gu5U5LlynCci-qTfOUaJ0bIq02ggFFt9I1ySbEYCDH42zYXrgt2meVqzWxWajzyvg78h7zqjBJKoV8mH0SnzXKe1fbFBqbqMOBynhUi_FaLdyT80YvNc5IEgvRijYCCnsfKofjagz7N9Tl7_Sy2Wb6-__9wQO01xJM_BgQcYg2bHmEdkLKye9j9P7mFZxw5TAwP1z46BCLg5wzLkpsPAjm99hHneB6Oa3m0FrUYfxwXeGprZUPQioMbp52BVmPEzTqP4-eXkibWoGYWPKaWCaY4Rl1EcsF15ZrpVNqdaRTIbiCXkBdUWo9PwHTOu6cTk0WKWoSG7NTtFVWpT1HGA4cUW5g8hoLZs6TLGM2YcoIaiW0ui66XZlrAsj17ghV2mq5mKwN1kVnweaTWZDYmDTe1CjmF3_4-hLtAosJIrX0CnUczFt7jbbNV10s5jcNJKAcDF9_AApFwiI
linkProvider	ProQuest
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Roles+of+the+immune+system+in+cancer%3A+from+tumor+initiation+to+metastatic+progression&rft.jtitle=Genes+%26+development&rft.au=Gonzalez%2C+Hugo&rft.au=Hagerling%2C+Catharina&rft.au=Werb%2C+Zena&rft.date=2018-10-01&rft.eissn=1549-5477&rft.volume=32&rft.issue=19-20&rft.spage=1267&rft_id=info:doi/10.1101%2Fgad.314617.118&rft_id=info%3Apmid%2F30275043&rft_id=info%3Apmid%2F30275043&rft.externalDocID=30275043
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1549-5477&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1549-5477&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1549-5477&client=summon