Particle-to-PFU ratio of Ebola virus influences disease course and survival in cynomolgus macaques

This study addresses the role of Ebola virus (EBOV) specific infectivity in virulence. Filoviruses are highly lethal, enveloped, single-stranded negative-sense RNA viruses that can cause hemorrhagic fever. No approved vaccines or therapies exist for filovirus infections, and infectious virus must be...

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Veröffentlicht in:	Journal of virology Jg. 89; H. 13; S. 6773
Hauptverfasser:	Alfson, Kendra J, Avena, Laura E, Beadles, Michael W, Staples, Hilary, Nunneley, Jerritt W, Ticer, Anysha, Dick, Jr, Edward J, Owston, Michael A, Reed, Christopher, Patterson, Jean L, Carrion, Jr, Ricardo, Griffiths, Anthony
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.07.2015
Schlagworte:	Animals Disease Models, Animal Ebolavirus - growth & development Ebolavirus - pathogenicity Ebolavirus - physiology Haplorhini Hemorrhagic Fever, Ebola - mortality Hemorrhagic Fever, Ebola - pathology Hemorrhagic Fever, Ebola - virology Macaca fascicularis Serial Passage Survival Analysis Viral Load Viral Plaque Assay Virulence
ISSN:	1098-5514, 1098-5514
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