Influence of APOE-2 genotype on the relation between adiposity and plasma lipid levels in patients with vascular disease

Background: Apolipoprotein E ( APOE ) genotypes are associated with different plasma lipid levels. People with the APO ɛ2 genotype can develop a disorder called dysbetalipoproteinemia (DBL). A possible predisposing factor for DBL is adiposity. We evaluated whether and to what extent the APOE genotyp...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	International Journal of Obesity Ročník 39; číslo 2; s. 265 - 269
Hlavní autoři:	Koopal, C, van der Graaf, Y, Asselbergs, F W, Westerink, J, Visseren, F L J
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 01.02.2015 Nature Publishing Group
Témata:	631/208/205 692/308/174 692/699/2743/393 692/699/75/2099 692/699/75/593 Abdomen Adipose tissue Adiposity - genetics Analysis Apolipoprotein E Apolipoprotein E2 - genetics Apolipoprotein E2 - metabolism Apolipoproteins Blood circulation disorders Blood lipids Body fat Body Fat Distribution Body Mass Index Body size Cardiovascular disease Causes of Cholesterol Cohort analysis Complications and side effects Confidence intervals Dependent variables Epidemiology Evaluation Female Genetic aspects Genetic Predisposition to Disease - genetics Genotype Genotype & phenotype Genotypes Health Promotion and Disease Prevention Health risk assessment Health sciences Heterozygotes High density lipoprotein Homozygotes Humans Hyperlipoproteinemia Type III - genetics Hyperlipoproteinemia Type III - metabolism Hyperlipoproteinemia Type III - physiopathology Internal Medicine Lipid metabolism Lipids Lipids - blood Lipids - genetics Lipoproteins Male Medicine Medicine & Public Health Metabolic Diseases Metabolic disorders Metabolic syndrome Metabolic Syndrome - genetics Metabolic Syndrome - metabolism Middle Aged Obesity Obesity, Abdominal - genetics Obesity, Abdominal - metabolism original-article Patients Physiological aspects Plasma Prospective Studies Public Health Regression analysis Statistical analysis Vascular diseases Vascular Diseases - genetics Vascular Diseases - metabolism Vascular Diseases - physiopathology Vein & artery diseases Netherlands
ISSN:	0307-0565, 1476-5497, 1476-5497
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	Background: Apolipoprotein E ( APOE ) genotypes are associated with different plasma lipid levels. People with the APO ɛ2 genotype can develop a disorder called dysbetalipoproteinemia (DBL). A possible predisposing factor for DBL is adiposity. We evaluated whether and to what extent the APOE genotype modifies the relation between adiposity and lipids in patients with manifest arterial disease and we looked at possible determinants of DBL in ɛ2 homo- and heterozygote patients. Methods: This prospective cohort study was performed in 5450 patients with manifest arterial disease from the Secondary Manifestations of ARTerial disease (SMART) study. The APOE genotype was measured in all patients and revealed 58 ɛ2 homozygotes, 663 ɛ2 heterozygotes, 3181 ɛ3 homozygotes and 1548 ɛ4 carriers. The main dependent variable was non-high-density lipoprotein cholesterol (non-HDL-c). The relation between adiposity (including body mass index (BMI), waist circumference (waist), visceral adipose tissue (VAT) and metabolic syndrome (MetS)) and lipids was evaluated with linear regression analyses. Determinants of DBL were evaluated using logistic regression. Results: There was significant effect modification by the APOE genotype on the relation between non-HDL-c and BMI, waist, VAT and MetS. There was an association between BMI and non-HDL-c in ɛ2 homozygotes ( β 0.173, 95% confidence interval (CI) 0.031–0.314, P =0.018) and ɛ4 carriers ( β 0.033, 95% CI 0.020–0.046, P <0.001). In all genotypes, there was an effect of waist, VAT and MetS on non-HDL-c, but these effects were most distinct in ɛ2 homozygotes (waist β 0.063, 95% CI 0.015–0.110, P =0.011; VAT β 0.580, 95% CI 0.270–0.889, P =0.001; MetS β 1.760, 95% CI 0.668–2.852, P =0.002). Determinants of DBL in ɛ2 homo- and heterozygotes were VAT and MetS. Conclusion: The APOE genotype modifies the relation between adiposity and plasma lipid levels in patients with vascular disease. The relation between adiposity and lipids is present in all patients, but it is most distinct in ɛ2 homozygote patients. Abdominal fat and MetS are determinants of DBL.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	0307-0565 1476-5497 1476-5497
DOI:	10.1038/ijo.2014.105