New Insights and Potential Therapeutic Interventions in Metabolic Diseases

Endocrine homeostasis and metabolic diseases have been the subject of extensive research in recent years. The development of new techniques and insights has led to a deeper understanding of the mechanisms underlying these conditions and opened up new avenues for diagnosis and treatment. In this revi...

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Vydané v:International journal of molecular sciences Ročník 24; číslo 13; s. 10672
Hlavní autori: Clemente-Suárez, Vicente Javier, Martín-Rodríguez, Alexandra, Redondo-Flórez, Laura, López-Mora, Clara, Yáñez-Sepúlveda, Rodrigo, Tornero-Aguilera, José Francisco
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Switzerland MDPI AG 26.06.2023
MDPI
Predmet:
Antioxidants
Behavior
Body fat
Cardiovascular disease
Care and treatment
Development and progression
Diabetes
Diet
Disease prevention
DNA methylation
Epigenesis, Genetic
Epigenetic inheritance
Epigenetics
Exercise
Gastrointestinal Microbiome
Gene expression
Glucose
Humans
Insulin resistance
Lipids
Liver diseases
Magnetic resonance imaging
Metabolic Diseases - metabolism
Metabolic Diseases - therapy
Metabolic disorders
Nutrition research
Obesity
Oxidative stress
Physical fitness
Review
Type 2 diabetes
Spain
genetic
microbiota
nutrition
single-cell transcriptomics
advanced imaging techniques
cell-based therapies
psychology
gut
epigenetics
physical activity
ISSN:1422-0067, 1661-6596, 1422-0067
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Abstract Endocrine homeostasis and metabolic diseases have been the subject of extensive research in recent years. The development of new techniques and insights has led to a deeper understanding of the mechanisms underlying these conditions and opened up new avenues for diagnosis and treatment. In this review, we discussed the rise of metabolic diseases, especially in Western countries, the genetical, psychological, and behavioral basis of metabolic diseases, the role of nutrition and physical activity in the development of metabolic diseases, the role of single-cell transcriptomics, gut microbiota, epigenetics, advanced imaging techniques, and cell-based therapies in metabolic diseases. Finally, practical applications derived from this information are made.
AbstractList Endocrine homeostasis and metabolic diseases have been the subject of extensive research in recent years. The development of new techniques and insights has led to a deeper understanding of the mechanisms underlying these conditions and opened up new avenues for diagnosis and treatment. In this review, we discussed the rise of metabolic diseases, especially in Western countries, the genetical, psychological, and behavioral basis of metabolic diseases, the role of nutrition and physical activity in the development of metabolic diseases, the role of single-cell transcriptomics, gut microbiota, epigenetics, advanced imaging techniques, and cell-based therapies in metabolic diseases. Finally, practical applications derived from this information are made.
Endocrine homeostasis and metabolic diseases have been the subject of extensive research in recent years. The development of new techniques and insights has led to a deeper understanding of the mechanisms underlying these conditions and opened up new avenues for diagnosis and treatment. In this review, we discussed the rise of metabolic diseases, especially in Western countries, the genetical, psychological, and behavioral basis of metabolic diseases, the role of nutrition and physical activity in the development of metabolic diseases, the role of single-cell transcriptomics, gut microbiota, epigenetics, advanced imaging techniques, and cell-based therapies in metabolic diseases. Finally, practical applications derived from this information are made.Endocrine homeostasis and metabolic diseases have been the subject of extensive research in recent years. The development of new techniques and insights has led to a deeper understanding of the mechanisms underlying these conditions and opened up new avenues for diagnosis and treatment. In this review, we discussed the rise of metabolic diseases, especially in Western countries, the genetical, psychological, and behavioral basis of metabolic diseases, the role of nutrition and physical activity in the development of metabolic diseases, the role of single-cell transcriptomics, gut microbiota, epigenetics, advanced imaging techniques, and cell-based therapies in metabolic diseases. Finally, practical applications derived from this information are made.
Audience Academic
Author Redondo-Flórez, Laura
Clemente-Suárez, Vicente Javier
López-Mora, Clara
Martín-Rodríguez, Alexandra
Yáñez-Sepúlveda, Rodrigo
Tornero-Aguilera, José Francisco
AuthorAffiliation 2 Grupo de Investigación en Cultura, Educación y Sociedad, Universidad de la Costa, Barranquilla 080002, Colombia
5 Faculty of Education and Social Sciences, Universidad Andres Bello, Viña del Mar 2520000, Chile
3 Department of Health Sciences, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Tajo Street s/n, 28670 Villaviciosa de Odon, Spain
1 Faculty of Sports Sciences, Universidad Europea de Madrid, Tajo Street, s/n, 28670 Madrid, Spain
4 Facultad de Ciencias Biomédicas y de la Salud, Universidad Europea de Valencia, Pg. de l’Albereda, 7, 46010 València, Spain
AuthorAffiliation_xml – name: 2 Grupo de Investigación en Cultura, Educación y Sociedad, Universidad de la Costa, Barranquilla 080002, Colombia
– name: 1 Faculty of Sports Sciences, Universidad Europea de Madrid, Tajo Street, s/n, 28670 Madrid, Spain
– name: 4 Facultad de Ciencias Biomédicas y de la Salud, Universidad Europea de Valencia, Pg. de l’Albereda, 7, 46010 València, Spain
– name: 3 Department of Health Sciences, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Tajo Street s/n, 28670 Villaviciosa de Odon, Spain
– name: 5 Faculty of Education and Social Sciences, Universidad Andres Bello, Viña del Mar 2520000, Chile
Author_xml – sequence: 1
  givenname: Vicente Javier
  orcidid: 0000-0002-2397-2801
  surname: Clemente-Suárez
  fullname: Clemente-Suárez, Vicente Javier
– sequence: 2
  givenname: Alexandra
  orcidid: 0000-0002-0087-4379
  surname: Martín-Rodríguez
  fullname: Martín-Rodríguez, Alexandra
– sequence: 3
  givenname: Laura
  orcidid: 0000-0002-1006-7642
  surname: Redondo-Flórez
  fullname: Redondo-Flórez, Laura
– sequence: 4
  givenname: Clara
  surname: López-Mora
  fullname: López-Mora, Clara
– sequence: 5
  givenname: Rodrigo
  orcidid: 0000-0002-9311-6576
  surname: Yáñez-Sepúlveda
  fullname: Yáñez-Sepúlveda, Rodrigo
– sequence: 6
  givenname: José Francisco
  surname: Tornero-Aguilera
  fullname: Tornero-Aguilera, José Francisco
BackLink https://www.ncbi.nlm.nih.gov/pubmed/37445852$$D View this record in MEDLINE/PubMed
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Keywords genetic
microbiota
nutrition
single-cell transcriptomics
advanced imaging techniques
cell-based therapies
psychology
gut
epigenetics
physical activity
Language English
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Snippet Endocrine homeostasis and metabolic diseases have been the subject of extensive research in recent years. The development of new techniques and insights has...
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SubjectTerms Antioxidants
Behavior
Body fat
Cardiovascular disease
Care and treatment
Development and progression
Diabetes
Diet
Disease prevention
DNA methylation
Epigenesis, Genetic
Epigenetic inheritance
Epigenetics
Exercise
Gastrointestinal Microbiome
Gene expression
Glucose
Humans
Insulin resistance
Lipids
Liver diseases
Magnetic resonance imaging
Metabolic Diseases - metabolism
Metabolic Diseases - therapy
Metabolic disorders
Nutrition research
Obesity
Oxidative stress
Physical fitness
Review
Type 2 diabetes
Title New Insights and Potential Therapeutic Interventions in Metabolic Diseases
URI https://www.ncbi.nlm.nih.gov/pubmed/37445852
https://www.proquest.com/docview/2836457008
https://www.proquest.com/docview/2838241916
https://pubmed.ncbi.nlm.nih.gov/PMC10342188
Volume 24
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