Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition

Antibodies targeting the SARS-CoV-2 spike receptor-binding domain (RBD) are being developed as therapeutics and are a major contributor to neutralizing antibody responses elicited by infection. Here, we describe a deep mutational scanning method to map how all amino-acid mutations in the RBD affect...

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Vydáno v:	Cell host & microbe Ročník 29; číslo 1; s. 44
Hlavní autoři:	Greaney, Allison J, Starr, Tyler N, Gilchuk, Pavlo, Zost, Seth J, Binshtein, Elad, Loes, Andrea N, Hilton, Sarah K, Huddleston, John, Eguia, Rachel, Crawford, Katharine H D, Dingens, Adam S, Nargi, Rachel S, Sutton, Rachel E, Suryadevara, Naveenchandra, Rothlauf, Paul W, Liu, Zhuoming, Whelan, Sean P J, Carnahan, Robert H, Crowe, Jr, James E, Bloom, Jesse D
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 13.01.2021
Témata:	Angiotensin-Converting Enzyme 2 - chemistry Angiotensin-Converting Enzyme 2 - metabolism Antibodies, Monoclonal - immunology Antibodies, Neutralizing - immunology Binding Sites Epitopes - immunology Gene Library High-Throughput Nucleotide Sequencing Humans Protein Domains Saccharomyces cerevisiae - genetics SARS-CoV-2 - genetics SARS-CoV-2 - immunology Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - genetics Spike Glycoprotein, Coronavirus - immunology Spike Glycoprotein, Coronavirus - metabolism antibody escape SARS-CoV-2 deep mutational scanning antigenic evolution
ISSN:	1934-6069, 1934-6069
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