Agmatine inhibits the proliferation of rat hepatoma cells by modulation of polyamine metabolism

Background/Aims: Previous experiments have shown that agmatine, the product of arginine decarboxylase, is transported in competition with putrescine into quiescent rat hepatocytes, where it promotes several effects, including marked decrease of intracellular polyamines and induction of apoptosis. Th...

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Bibliographic Details
Published in:	Journal of hepatology Vol. 39; no. 5; pp. 793 - 799
Main Authors:	Gardini, Giulia, Cravanzola, Carlo, Autelli, Riccardo, Testore, Giovanni, Cesa, Roberta, Morando, Laura, Solinas, Sandro Paolo, Muzio, Giuliana, Grillo, Maria Angelica, Colombatto, Sebastiano
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.11.2003
Subjects:	Actins - metabolism Agmatine Agmatine - administration & dosage Agmatine - pharmacology Animals Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - ultrastructure Cell Division - drug effects Cell Line, Tumor Cytoskeleton - metabolism Cytoskeleton - ultrastructure Dose-Response Relationship, Drug G2 Phase Hepatoma cell Immunohistochemistry - methods Liver Neoplasms - metabolism Liver Neoplasms - pathology Liver Neoplasms - ultrastructure Microscopy, Electron Mitosis Polyamine Polyamines - antagonists & inhibitors Rats Staining and Labeling Tubulin - metabolism Hepatoma cell Agmatine Polyamine
ISSN:	0168-8278, 1600-0641
Online Access:	Get full text
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