Aortic stiffness, pressure and flow pulsatility, and target organ damage

Measures of aortic stiffness and pressure and flow pulsatility have emerged as correlates of and potential contributors to cardiovascular disease, dementia, and kidney disease. Higher aortic stiffness and greater pressure and flow pulsatility are associated with excessive pulsatile load on the heart...

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Veröffentlicht in:Journal of applied physiology (1985) Jg. 125; H. 6; S. 1871
1. Verfasser: Mitchell, Gary F
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.12.2018
Schlagworte:
Animals
Aorta - physiology
Brain - physiology
Disease - etiology
Humans
Hypertension - physiopathology
Kidney - physiology
Microvessels - physiology
Pulsatile Flow
Sex Characteristics
Vascular Stiffness
Ventricular Function, Left
cardiovascular disease
dementia
chronic kidney disease
aorta
pulsatility index
hemodynamics
ISSN:1522-1601, 1522-1601
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Abstract Measures of aortic stiffness and pressure and flow pulsatility have emerged as correlates of and potential contributors to cardiovascular disease, dementia, and kidney disease. Higher aortic stiffness and greater pressure and flow pulsatility are associated with excessive pulsatile load on the heart, which increases mass and reduces global longitudinal strain of the left ventricle. Excessive stiffness and pulsatility are also associated with microvascular lesions in high-flow organs, such as the brain and kidney, suggesting that small vessels in these organs are damaged by pulsatility. This brief review will summarize evidence relating aortic stiffness to cardiovascular, brain, and kidney disease.
AbstractList Measures of aortic stiffness and pressure and flow pulsatility have emerged as correlates of and potential contributors to cardiovascular disease, dementia, and kidney disease. Higher aortic stiffness and greater pressure and flow pulsatility are associated with excessive pulsatile load on the heart, which increases mass and reduces global longitudinal strain of the left ventricle. Excessive stiffness and pulsatility are also associated with microvascular lesions in high-flow organs, such as the brain and kidney, suggesting that small vessels in these organs are damaged by pulsatility. This brief review will summarize evidence relating aortic stiffness to cardiovascular, brain, and kidney disease.Measures of aortic stiffness and pressure and flow pulsatility have emerged as correlates of and potential contributors to cardiovascular disease, dementia, and kidney disease. Higher aortic stiffness and greater pressure and flow pulsatility are associated with excessive pulsatile load on the heart, which increases mass and reduces global longitudinal strain of the left ventricle. Excessive stiffness and pulsatility are also associated with microvascular lesions in high-flow organs, such as the brain and kidney, suggesting that small vessels in these organs are damaged by pulsatility. This brief review will summarize evidence relating aortic stiffness to cardiovascular, brain, and kidney disease.
Measures of aortic stiffness and pressure and flow pulsatility have emerged as correlates of and potential contributors to cardiovascular disease, dementia, and kidney disease. Higher aortic stiffness and greater pressure and flow pulsatility are associated with excessive pulsatile load on the heart, which increases mass and reduces global longitudinal strain of the left ventricle. Excessive stiffness and pulsatility are also associated with microvascular lesions in high-flow organs, such as the brain and kidney, suggesting that small vessels in these organs are damaged by pulsatility. This brief review will summarize evidence relating aortic stiffness to cardiovascular, brain, and kidney disease.
Author Mitchell, Gary F
Author_xml – sequence: 1
  givenname: Gary F
  surname: Mitchell
  fullname: Mitchell, Gary F
  organization: Cardiovascular Engineering, Incorporated, Norwood, Massachusetts
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30359540$$D View this record in MEDLINE/PubMed
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Keywords cardiovascular disease
dementia
chronic kidney disease
aorta
pulsatility index
hemodynamics
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SubjectTerms Animals
Aorta - physiology
Brain - physiology
Disease - etiology
Humans
Hypertension - physiopathology
Kidney - physiology
Microvessels - physiology
Pulsatile Flow
Sex Characteristics
Vascular Stiffness
Ventricular Function, Left
Title Aortic stiffness, pressure and flow pulsatility, and target organ damage
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