Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management

Staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. It is a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections. This review comprehensively covers the epid...

Full description

Saved in:

Bibliographic Details
Published in:	Clinical microbiology reviews Vol. 28; no. 3; p. 603
Main Authors:	Tong, Steven Y C, Davis, Joshua S, Eichenberger, Emily, Holland, Thomas L, Fowler, Jr, Vance G
Format:	Journal Article
Language:	English
Published:	United States 01.07.2015
Subjects:	beta-Lactam Resistance - genetics Community-Acquired Infections - epidemiology Community-Acquired Infections - microbiology Cross Infection - epidemiology Cross Infection - microbiology Humans Prosthesis-Related Infections - epidemiology Prosthesis-Related Infections - microbiology Risk Factors Staphylococcal Infections - epidemiology Staphylococcal Infections - microbiology Staphylococcal Infections - pathology Staphylococcal Infections - therapy Staphylococcus aureus - genetics Staphylococcus aureus - pathogenicity Virulence Factors - genetics
ISSN:	1098-6618, 1098-6618
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. It is a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections. This review comprehensively covers the epidemiology, pathophysiology, clinical manifestations, and management of each of these clinical entities. The past 2 decades have witnessed two clear shifts in the epidemiology of S. aureus infections: first, a growing number of health care-associated infections, particularly seen in infective endocarditis and prosthetic device infections, and second, an epidemic of community-associated skin and soft tissue infections driven by strains with certain virulence factors and resistance to β-lactam antibiotics. In reviewing the literature to support management strategies for these clinical manifestations, we also highlight the paucity of high-quality evidence for many key clinical questions.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1098-6618 1098-6618
DOI:	10.1128/CMR.00134-14