Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management

Staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. It is a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections. This review comprehensively covers the epid...

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Veröffentlicht in:Clinical microbiology reviews Jg. 28; H. 3; S. 603
Hauptverfasser: Tong, Steven Y C, Davis, Joshua S, Eichenberger, Emily, Holland, Thomas L, Fowler, Jr, Vance G
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.07.2015
Schlagworte:
beta-Lactam Resistance - genetics
Community-Acquired Infections - epidemiology
Community-Acquired Infections - microbiology
Cross Infection - epidemiology
Cross Infection - microbiology
Humans
Prosthesis-Related Infections - epidemiology
Prosthesis-Related Infections - microbiology
Risk Factors
Staphylococcal Infections - epidemiology
Staphylococcal Infections - microbiology
Staphylococcal Infections - pathology
Staphylococcal Infections - therapy
Staphylococcus aureus - genetics
Staphylococcus aureus - pathogenicity
Virulence Factors - genetics
ISSN:1098-6618, 1098-6618
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Zusammenfassung:Staphylococcus aureus is a major human pathogen that causes a wide range of clinical infections. It is a leading cause of bacteremia and infective endocarditis as well as osteoarticular, skin and soft tissue, pleuropulmonary, and device-related infections. This review comprehensively covers the epidemiology, pathophysiology, clinical manifestations, and management of each of these clinical entities. The past 2 decades have witnessed two clear shifts in the epidemiology of S. aureus infections: first, a growing number of health care-associated infections, particularly seen in infective endocarditis and prosthetic device infections, and second, an epidemic of community-associated skin and soft tissue infections driven by strains with certain virulence factors and resistance to β-lactam antibiotics. In reviewing the literature to support management strategies for these clinical manifestations, we also highlight the paucity of high-quality evidence for many key clinical questions.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1098-6618
1098-6618
DOI:10.1128/CMR.00134-14