A live-attenuated Listeria vaccine (ANZ-100) and a live-attenuated Listeria vaccine expressing mesothelin (CRS-207) for advanced cancers: phase I studies of safety and immune induction

Listeria monocytogenes (Lm)-based vaccines stimulate both innate and adaptive immunity. ANZ-100 is a live-attenuated Lm strain (Lm ΔactA/ΔinlB). Uptake by phagocytes in the liver results in local inflammatory responses and activation and recruitment of natural killer (NK) and T cells, in association...

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Veröffentlicht in:	Clinical cancer research Jg. 18; H. 3; S. 858
Hauptverfasser:	Le, Dung T, Brockstedt, Dirk G, Nir-Paz, Ran, Hampl, Johannes, Mathur, Shruti, Nemunaitis, John, Sterman, Daniel H, Hassan, Raffit, Lutz, Eric, Moyer, Bentley, Giedlin, Martin, Louis, Jana-Lynn, Sugar, Elizabeth A, Pons, Alice, Cox, Andrea L, Levine, Jordana, Murphy, Aimee Luck, Illei, Peter, Dubensky, Jr, Thomas W, Eiden, Joseph E, Jaffee, Elizabeth M, Laheru, Daniel A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.02.2012
Schlagworte:	Adult Aged Bacterial Vaccines - administration & dosage Bacterial Vaccines - adverse effects Bacterial Vaccines - immunology Cancer Vaccines - administration & dosage Cancer Vaccines - adverse effects Cancer Vaccines - immunology Carcinoma - secondary Carcinoma - therapy Cytokines - blood Female Flow Cytometry GPI-Linked Proteins - immunology Humans Immunohistochemistry Listeria monocytogenes - immunology Liver Neoplasms - immunology Liver Neoplasms - secondary Liver Neoplasms - therapy Lung Neoplasms - pathology Lung Neoplasms - therapy Lymphocyte Activation - immunology Lymphocyte Count Male Maximum Tolerated Dose Mesothelin Mesothelioma - pathology Mesothelioma - therapy Middle Aged Ovarian Neoplasms - pathology Ovarian Neoplasms - therapy Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - adverse effects Vaccines, Attenuated - immunology
ISSN:	1557-3265, 1557-3265
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