Implications of new monoclonal antibodies and the crystal structure of the TSH receptor for the treatment and management of thyroid diseases

Autoantibodies to the thyroid-stimulating hormone receptor (TSHR) cause the hyperthyroidism of Graves ’ disease and contribute to Graves ’ eye signs. Human monoclonal TSHR autoantibodies prepared from patients ’ lymphocytes have important clinical applications in terms of their ability to stimulate...

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Bibliographic Details
Published in:	Biomarkers in medicine Vol. 2; no. 6; pp. 567 - 576
Main Authors:	Rees Smith, Bernard, Sanders, Jane, Furmaniak, Jadwiga
Format:	Journal Article
Language:	English
Published:	England Future Medicine Ltd 01.12.2008
Subjects:	Autoantibodies Autoimmunity Binding sites Cancer Care and treatment Crystals Disease Eye diseases Graves ’ disease Hormones Hypothyroidism Immune system Inventors Lymphocytes Molecular weight Monoclonal antibodies Proteins Structure thyroid Thyroid diseases Thyroid gland thyroid-stimulating hormone Thyrotropin TSH TSH receptor
ISSN:	1752-0363, 1752-0371, 1752-0371
Online Access:	Get full text
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