High secretion of interferons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus

The Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in 2012 as the causative agent of a severe respiratory disease with a fatality rate of approximately 30%. The high virulence and mortality rate prompted us to analyze aspects of MERS-CoV pathogenesis, especially its interaction with...

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Bibliographic Details

Published in:	Journal of virology Vol. 89; no. 7; p. 3859
Main Authors:	Scheuplein, Vivian A, Seifried, Janna, Malczyk, Anna H, Miller, Lilija, Höcker, Lena, Vergara-Alert, Júlia, Dolnik, Olga, Zielecki, Florian, Becker, Björn, Spreitzer, Ingo, König, Renate, Becker, Stephan, Waibler, Zoe, Mühlebach, Michael D
Format:	Journal Article
Language:	English
Published:	United States 01.04.2015
Subjects:	Animals Dendritic Cells - immunology Dendritic Cells - virology Dipeptidyl Peptidase 4 - metabolism Endocytosis Endosomes - metabolism Endosomes - virology Humans Interferons - secretion Mice, Inbred C57BL Middle East Respiratory Syndrome Coronavirus - immunology Virus Internalization
ISSN:	1098-5514, 1098-5514
Online Access:	Get more information
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