In vivo evaluation of a breast-specific magnetic resonance guided focused ultrasound system in a goat udder model

Purpose: This work further evaluates the functionality, efficacy, and safety of a new breast-specific magnetic resonance guided high intensity focused ultrasound (MRgFUS) system in anin vivo goat udder model. Methods: Eight female goats underwent an MRgFUS ablation procedure using the breast-specifi...

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Vydáno v:Medical physics (Lancaster) Ročník 40; číslo 7; s. 073302 - n/a
Hlavní autoři: Payne, A., Todd, N., Minalga, E., Wang, Y., Diakite, M., Hadley, R., Merrill, R., Factor, R., Neumayer, L., Parker, D. L.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States American Association of Physicists in Medicine 01.07.2013
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ISSN:0094-2405, 2473-4209, 2473-4209, 0094-2405
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Abstract Purpose: This work further evaluates the functionality, efficacy, and safety of a new breast-specific magnetic resonance guided high intensity focused ultrasound (MRgFUS) system in anin vivo goat udder model. Methods: Eight female goats underwent an MRgFUS ablation procedure using the breast-specific MRgFUS system. Tissue classification was achieved through the 3D magnetic resonance imaging (MRI) acquisition of several contrasts (T1w, T2w, PDw, 3-point Dixon). The MRgFUS treatment was performed with a grid trajectory executed in one or two planes within the glandular tissue of the goat udder. Temperature was monitored using a 3D proton resonance frequency (PRF) MRI technique. Delayed contrast enhanced-MR images were acquired immediately and 14 days post MRgFUS treatment. A localized tissue excision was performed in one animal and histological analysis was performed. Animals were available for adoption at the conclusion of the study. Results: The breast-specific MRgFUS system was able to ablate regions ranging in size from 0.4 to 3.6 cm3 in the goat udder model. Tissue damage was confirmed through the correlation of thermal dose measurements obtained with realtime 3D MR thermometry to delayed contrast enhanced-MR images immediately after the treatment and 14 days postablation. In general, lesions were longer in the ultrasound propagation direction, which is consistent with the dimensions of the ultrasound focal spot. Thermal dose volumes had better agreement with nonenhancing areas of the DCE-MRI images obtained 14 days after the MRgFUS treatment. Conclusions: The system was able to successfully ablate lesions up to 3.6 cm3. The thermal dose volume was found to correlate better with the 14-day postablation nonenhancing delayed contrast enhanced-MR image volumes. While the goat udder is not an ideal model for the human breast, this study has proven the feasibility of using this system on a wide variety of udder shapes and sizes, demonstrating the flexibility that would be required in order to treat human subjects.
AbstractList Purpose: This work further evaluates the functionality, efficacy, and safety of a new breast‐specific magnetic resonance guided high intensity focused ultrasound (MRgFUS) system in anin vivo goat udder model. Methods: Eight female goats underwent an MRgFUS ablation procedure using the breast‐specific MRgFUS system. Tissue classification was achieved through the 3D magnetic resonance imaging (MRI) acquisition of several contrasts (T1w, T2w, PDw, 3‐point Dixon). The MRgFUS treatment was performed with a grid trajectory executed in one or two planes within the glandular tissue of the goat udder. Temperature was monitored using a 3D proton resonance frequency (PRF) MRI technique. Delayed contrast enhanced‐MR images were acquired immediately and 14 days post MRgFUS treatment. A localized tissue excision was performed in one animal and histological analysis was performed. Animals were available for adoption at the conclusion of the study. Results: The breast‐specific MRgFUS system was able to ablate regions ranging in size from 0.4 to 3.6 cm3 in the goat udder model. Tissue damage was confirmed through the correlation of thermal dose measurements obtained with realtime 3D MR thermometry to delayed contrast enhanced‐MR images immediately after the treatment and 14 days postablation. In general, lesions were longer in the ultrasound propagation direction, which is consistent with the dimensions of the ultrasound focal spot. Thermal dose volumes had better agreement with nonenhancing areas of the DCE‐MRI images obtained 14 days after the MRgFUS treatment. Conclusions: The system was able to successfully ablate lesions up to 3.6 cm3. The thermal dose volume was found to correlate better with the 14‐day postablation nonenhancing delayed contrast enhanced‐MR image volumes. While the goat udder is not an ideal model for the human breast, this study has proven the feasibility of using this system on a wide variety of udder shapes and sizes, demonstrating the flexibility that would be required in order to treat human subjects.
Purpose: This work further evaluates the functionality, efficacy, and safety of a new breast-specific magnetic resonance guided high intensity focused ultrasound (MRgFUS) system in an in vivo goat udder model. Methods: Eight female goats underwent an MRgFUS ablation procedure using the breast-specific MRgFUS system. Tissue classification was achieved through the 3D magnetic resonance imaging (MRI) acquisition of several contrasts (T1w, T2w, PDw, 3-point Dixon). The MRgFUS treatment was performed with a grid trajectory executed in one or two planes within the glandular tissue of the goat udder. Temperature was monitored using a 3D proton resonance frequency (PRF) MRI technique. Delayed contrast enhanced-MR images were acquired immediately and 14 days post MRgFUS treatment. A localized tissue excision was performed in one animal and histological analysis was performed. Animals were available for adoption at the conclusion of the study. Results: The breast-specific MRgFUS system was able to ablate regions ranging in size from 0.4 to 3.6 cm3 in the goat udder model. Tissue damage was confirmed through the correlation of thermal dose measurements obtained with realtime 3D MR thermometry to delayed contrast enhanced-MR images immediately after the treatment and 14 days postablation. In general, lesions were longer in the ultrasound propagation direction, which is consistent with the dimensions of the ultrasound focal spot. Thermal dose volumes had better agreement with nonenhancing areas of the DCE-MRI images obtained 14 days after the MRgFUS treatment. Conclusions: The system was able to successfully ablate lesions up to 3.6 cm3. The thermal dose volume was found to correlate better with the 14-day postablation nonenhancing delayed contrast enhanced-MR image volumes. While the goat udder is not an ideal model for the human breast, this study has proven the feasibility of using this system on a wide variety of udder shapes and sizes, demonstrating the flexibility that would be required in order to treat human subjects.
This work further evaluates the functionality, efficacy, and safety of a new breast-specific magnetic resonance guided high intensity focused ultrasound (MRgFUS) system in an in vivo goat udder model. Eight female goats underwent an MRgFUS ablation procedure using the breast-specific MRgFUS system. Tissue classification was achieved through the 3D magnetic resonance imaging (MRI) acquisition of several contrasts (T1w, T2w, PDw, 3-point Dixon). The MRgFUS treatment was performed with a grid trajectory executed in one or two planes within the glandular tissue of the goat udder. Temperature was monitored using a 3D proton resonance frequency (PRF) MRI technique. Delayed contrast enhanced-MR images were acquired immediately and 14 days post MRgFUS treatment. A localized tissue excision was performed in one animal and histological analysis was performed. Animals were available for adoption at the conclusion of the study. The breast-specific MRgFUS system was able to ablate regions ranging in size from 0.4 to 3.6 cm(3) in the goat udder model. Tissue damage was confirmed through the correlation of thermal dose measurements obtained with realtime 3D MR thermometry to delayed contrast enhanced-MR images immediately after the treatment and 14 days postablation. In general, lesions were longer in the ultrasound propagation direction, which is consistent with the dimensions of the ultrasound focal spot. Thermal dose volumes had better agreement with nonenhancing areas of the DCE-MRI images obtained 14 days after the MRgFUS treatment. The system was able to successfully ablate lesions up to 3.6 cm(3). The thermal dose volume was found to correlate better with the 14-day postablation nonenhancing delayed contrast enhanced-MR image volumes. While the goat udder is not an ideal model for the human breast, this study has proven the feasibility of using this system on a wide variety of udder shapes and sizes, demonstrating the flexibility that would be required in order to treat human subjects.
This work further evaluates the functionality, efficacy, and safety of a new breast-specific magnetic resonance guided high intensity focused ultrasound (MRgFUS) system in an in vivo goat udder model.PURPOSEThis work further evaluates the functionality, efficacy, and safety of a new breast-specific magnetic resonance guided high intensity focused ultrasound (MRgFUS) system in an in vivo goat udder model.Eight female goats underwent an MRgFUS ablation procedure using the breast-specific MRgFUS system. Tissue classification was achieved through the 3D magnetic resonance imaging (MRI) acquisition of several contrasts (T1w, T2w, PDw, 3-point Dixon). The MRgFUS treatment was performed with a grid trajectory executed in one or two planes within the glandular tissue of the goat udder. Temperature was monitored using a 3D proton resonance frequency (PRF) MRI technique. Delayed contrast enhanced-MR images were acquired immediately and 14 days post MRgFUS treatment. A localized tissue excision was performed in one animal and histological analysis was performed. Animals were available for adoption at the conclusion of the study.METHODSEight female goats underwent an MRgFUS ablation procedure using the breast-specific MRgFUS system. Tissue classification was achieved through the 3D magnetic resonance imaging (MRI) acquisition of several contrasts (T1w, T2w, PDw, 3-point Dixon). The MRgFUS treatment was performed with a grid trajectory executed in one or two planes within the glandular tissue of the goat udder. Temperature was monitored using a 3D proton resonance frequency (PRF) MRI technique. Delayed contrast enhanced-MR images were acquired immediately and 14 days post MRgFUS treatment. A localized tissue excision was performed in one animal and histological analysis was performed. Animals were available for adoption at the conclusion of the study.The breast-specific MRgFUS system was able to ablate regions ranging in size from 0.4 to 3.6 cm(3) in the goat udder model. Tissue damage was confirmed through the correlation of thermal dose measurements obtained with realtime 3D MR thermometry to delayed contrast enhanced-MR images immediately after the treatment and 14 days postablation. In general, lesions were longer in the ultrasound propagation direction, which is consistent with the dimensions of the ultrasound focal spot. Thermal dose volumes had better agreement with nonenhancing areas of the DCE-MRI images obtained 14 days after the MRgFUS treatment.RESULTSThe breast-specific MRgFUS system was able to ablate regions ranging in size from 0.4 to 3.6 cm(3) in the goat udder model. Tissue damage was confirmed through the correlation of thermal dose measurements obtained with realtime 3D MR thermometry to delayed contrast enhanced-MR images immediately after the treatment and 14 days postablation. In general, lesions were longer in the ultrasound propagation direction, which is consistent with the dimensions of the ultrasound focal spot. Thermal dose volumes had better agreement with nonenhancing areas of the DCE-MRI images obtained 14 days after the MRgFUS treatment.The system was able to successfully ablate lesions up to 3.6 cm(3). The thermal dose volume was found to correlate better with the 14-day postablation nonenhancing delayed contrast enhanced-MR image volumes. While the goat udder is not an ideal model for the human breast, this study has proven the feasibility of using this system on a wide variety of udder shapes and sizes, demonstrating the flexibility that would be required in order to treat human subjects.CONCLUSIONSThe system was able to successfully ablate lesions up to 3.6 cm(3). The thermal dose volume was found to correlate better with the 14-day postablation nonenhancing delayed contrast enhanced-MR image volumes. While the goat udder is not an ideal model for the human breast, this study has proven the feasibility of using this system on a wide variety of udder shapes and sizes, demonstrating the flexibility that would be required in order to treat human subjects.
Author Factor, R.
Merrill, R.
Minalga, E.
Hadley, R.
Wang, Y.
Neumayer, L.
Diakite, M.
Payne, A.
Todd, N.
Parker, D. L.
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Keywords breast cancer
magnetic resonance
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Snippet Purpose: This work further evaluates the functionality, efficacy, and safety of a new breast-specific magnetic resonance guided high intensity focused...
Purpose: This work further evaluates the functionality, efficacy, and safety of a new breast‐specific magnetic resonance guided high intensity focused...
This work further evaluates the functionality, efficacy, and safety of a new breast-specific magnetic resonance guided high intensity focused ultrasound...
Purpose: This work further evaluates the functionality, efficacy, and safety of a new breast-specific magnetic resonance guided high intensity focused...
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pubmed
crossref
wiley
scitation
SourceType Open Access Repository
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StartPage 073302
SubjectTerms Animals
biological organs
biological tissues
biomedical MRI
biomedical ultrasonics
biothermics
Biothermics and thermal processes in biology
breast cancer
Contrast Media
Diagnosis using ultrasonic, sonic or infrasonic waves
Digital computing or data processing equipment or methods, specially adapted for specific applications
dosimetry
Female
focused ultrasound
Goats
image classification
Image data processing or generation, in general
Image enhancement
Image enhancement or restoration, e.g. from bit‐mapped to bit‐mapped creating a similar image
Involving electronic [emr] or nuclear [nmr] magnetic resonance, e.g. magnetic resonance imaging
magnetic resonance
Magnetic Resonance Imaging
Mammary Glands, Animal - diagnostic imaging
Measuring temperature; Measuring quantity of heat; Thermally‐sensitive elements not otherwise provided for
Medical image contrast
medical image processing
Medical imaging
Organ Specificity
Safety
temperature measurement
Therapeutic applications
Thermal imaging
Thermometers
thermometry
Thermotherapy Physics
Tissue ablation
Tissues
Transducers
ultrasonic propagation
ultrasonic therapy
Ultrasonic transducers
Ultrasonography
Ultrasonography, Mammary - methods
Ultrasound therapy
Title In vivo evaluation of a breast-specific magnetic resonance guided focused ultrasound system in a goat udder model
URI http://dx.doi.org/10.1118/1.4811103
https://onlinelibrary.wiley.com/doi/abs/10.1118%2F1.4811103
https://www.ncbi.nlm.nih.gov/pubmed/23822456
https://www.proquest.com/docview/1398424339
https://pubmed.ncbi.nlm.nih.gov/PMC3702593
Volume 40
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