The role of plasminogen activator inhibitor type 1 in the inflammatory response to local tissue injury

Background: The plasma levels of the plasminogen activator‐inhibitor type 1 (PAI‐1) are consistently elevated in patients with sterile tissue injury, often accompanied by a systemic acute phase protein response. It remains unknown, however, whether and to what extent PAI‐1 affects the host response...

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Bibliographic Details
Published in:	Journal of thrombosis and haemostasis Vol. 3; no. 5; pp. 1018 - 1025
Main Authors:	RENCKENS, R., ROELOFS, J. J. T. H., DE WAARD, V., FLORQUIN, S., LIJNEN, H. R., CARMELIET, P., VAN DER POLL, T.
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Science Inc 01.05.2005
Subjects:	acute phase response Acute-Phase Proteins - metabolism Acute-Phase Reaction Animals Body Weight Chemokines - metabolism Dose-Response Relationship, Drug Edema Endothelium, Vascular - metabolism Female In Situ Hybridization Inflammation Interleukin-1 - biosynthesis Interleukin-6 - biosynthesis Interleukin-6 - metabolism Macrophages - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Necrosis Neutrophils - metabolism PAI‐1 Plasminogen Activator Inhibitor 1 - physiology RNA, Messenger - metabolism Time Factors Turpentine - pharmacology
ISSN:	1538-7933, 1538-7836, 1538-7836
Online Access:	Get full text
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