Friedreich's ataxia–associated GAA repeats induce replication-fork reversal and unusual molecular junctions

Friedreich's ataxia is one of several hereditary neurodegenerative disorders caused expansion of trinucleotide repeats, but the mechanism of their genomic propagation is unknown. A new plasmid-based system to probe human replicative intermediates reveals that GAA/TTC repeats interfere with repl...

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Vydané v:	Nature structural & molecular biology Ročník 20; číslo 4; s. 486 - 494
Hlavní autori:	Follonier, Cindy, Oehler, Judith, Herrador, Raquel, Lopes, Massimo
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	New York Nature Publishing Group US 01.04.2013 Nature Publishing Group
Predmet:	631/337/151 631/378/1689/2014 631/45/535 Ataxia Biochemistry Biological Microscopy Care and treatment Crystal structure DNA Replication Electrophoresis Friedreich Ataxia - genetics Genetic aspects Genetic disorders Humans Life Sciences Membrane Biology Molecular biology Neurodegeneration Plasmids Protein Structure Repetitive Sequences, Nucleic Acid Signal transduction Switzerland
ISSN:	1545-9993, 1545-9985, 1545-9985
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