Caveolin-1 is a negative regulator of tumor growth in glioblastoma and modulates chemosensitivity to temozolomide

Caveolin-1 (Cav-1) is a critical regulator of tumor progression in a variety of cancers where it has been shown to act as either a tumor suppressor or tumor promoter. In glioblastoma multiforme, it has been previously demonstrated to function as a putative tumor suppressor. Our studies here, using t...

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Vol. 12; no. 10; pp. 1510 - 1520
Main Authors:	Quann, Kevin, Gonzales, Donna M., Mercier, Isabelle, Wang, Chenguang, Sotgia, Federica, Pestell, Richard G., Lisanti, Michael P., Jasmin, Jean-François
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 15.05.2013 Landes Bioscience
Subjects:	Animals Apoptosis - drug effects Biomarkers, Tumor - metabolism brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Brain Neoplasms - pathology Caveolin 1 - genetics Caveolin 1 - metabolism Caveolin-1 Cell Line, Tumor chemotherapy Dacarbazine - analogs & derivatives Dacarbazine - pharmacology Dacarbazine - therapeutic use Down-Regulation Glioblastoma - drug therapy Glioblastoma - metabolism Glioblastoma - pathology glioma Humans Lentivirus - genetics Mice microarray Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism mouse model Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Signal Transduction temozolomide TOR Serine-Threonine Kinases - metabolism Transplantation, Heterologous tumor progression tumor suppressor Caveolin-1 temozolomide microarray tumor progression mouse model glioma tumor suppressor brain cancer chemotherapy
ISSN:	1538-4101, 1551-4005, 1551-4005
Online Access:	Get full text
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