Ketones and lactate "fuel" tumor growth and metastasis Evidence that epithelial cancer cells use oxidative mitochondrial metabolism

Previously, we proposed a new model for understanding the "Warburg effect" in tumor metabolism. In this scheme, cancer-associated fibroblasts undergo aerobic glycolysis and the resulting energy-rich metabolites are then transferred to epithelial cancer cells, where they enter the TCA cycle...

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Vol. 9; no. 17; pp. 3506 - 3514
Main Authors:	Bonuccelli, Gloria, Tsirigos, Aristotelis, Whitaker-Menezes, Diana, Pavlides, Stephanos, Pestell, Richard G., Chiavarina, Barbara, Frank, Philippe G., Flomenberg, Neal, Howell, Anthony, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 01.09.2010 Landes Bioscience
Subjects:	3-Hydroxybutyric Acid - metabolism 3-Hydroxybutyric Acid - pharmacology Animals Autophagy Binding Biology Bioscience Breast Neoplasms - metabolism Breast Neoplasms - pathology Calcium Cancer Cell Cell Line, Tumor Cell Movement Cycle Female Glycolysis Humans Lactic Acid - pharmacology Landes Lung Neoplasms - pathology Lung Neoplasms - secondary Mice Mitochondria - metabolism Organogenesis Oxidative Phosphorylation Proteins Stromal Cells - metabolism Transplantation, Heterologous Up-Regulation
ISSN:	1538-4101, 1551-4005, 1551-4005
Online Access:	Get full text
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