Natural killer T cells in adipose tissue prevent insulin resistance

Lipid overload and adipocyte dysfunction are key to the development of insulin resistance and can be induced by a high-fat diet. CD1d-restricted invariant natural killer T (iNKT) cells have been proposed as mediators between lipid overload and insulin resistance, but recent studies found decreased i...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 122; no. 9; pp. 3343 - 3354
Main Authors:	Schipper, Henk S., Rakhshandehroo, Maryam, van de Graaf, Stan F.J., Venken, Koen, Koppen, Arjen, Stienstra, Rinke, Prop, Serge, Meerding, Jenny, Hamers, Nicole, Besra, Gurdyal, Boon, Louis, Nieuwenhuis, Edward E.S., Elewaut, Dirk, Prakken, Berent, Kersten, Sander, Boes, Marianne, Kalkhoven, Eric
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01.09.2012
Subjects:	Adipocytes Adipocytes - metabolism Adipose tissues alternatively activated macrophages Animals Antibodies Antigens Antigens, CD1d - genetics Antigens, CD1d - metabolism Biomedical research Body fat Cell Line Cells Coculture Techniques Cytokines Cytokines - genetics Cytokines - metabolism Cytokines - secretion Diet Diet, High-Fat disease Down-Regulation fat Gene Expression Genotype & phenotype Glucose hepatic steatosis Homeostasis Humans Inflammation innate immunity Insulin resistance Insulin Resistance - immunology Intra-Abdominal Fat - immunology Intra-Abdominal Fat - pathology Intra-Abdominal Fat - physiopathology invariant nkt cells Killer cells Lipids Liver Liver - metabolism Liver - pathology Lymphocyte Depletion Lymphocytes metabolic syndrome Metabolism Mice Mice, Inbred C57BL Natural Killer T-Cells - metabolism Natural Killer T-Cells - physiology nonobese diabetic mice obese mice Oligonucleotide Array Sequence Analysis Physiological aspects Prevention Receptors, CCR2 - metabolism Risk factors Subcutaneous Fat - immunology Subcutaneous Fat - pathology Subcutaneous Fat - physiopathology T cells T-Lymphocytes, Regulatory - pathology Transcriptome Triglycerides - metabolism United States
ISSN:	0021-9738, 1558-8238, 1558-8238
Online Access:	Get full text
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