Single cell behavior in T cell differentiation

•Upon antigen encounter, proliferating T cells diversify in function and phenotype.•Lineage tracing demonstrates that the output of individual T cells is highly variable.•Reproducibility of T cell responses is due to the averaging of disparate single cell behaviors.•Variability in T cell output may...

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Bibliographic Details
Published in:	Trends in immunology Vol. 35; no. 4; pp. 170 - 177
Main Authors:	Rohr, Jan C., Gerlach, Carmen, Kok, Lianne, Schumacher, Ton N.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.04.2014 Elsevier Limited
Subjects:	Allergy and Immunology Animals Antigens Apoptosis asymmetric cell division Asymmetry Behavior Cell Differentiation - immunology Cell division cell-extrinsic signals cellular heterogeneity Daughters Epigenetics Humans Immunology Infections Lymphocyte Activation - immunology Lymphocytes Population population asymmetry single-cell tracking Stem cells Studies T cell differentiation T-Lymphocytes - cytology T-Lymphocytes - immunology asymmetric cell division cellular heterogeneity cell-extrinsic signals single-cell tracking population asymmetry T cell differentiation
ISSN:	1471-4906, 1471-4981, 1471-4981
Online Access:	Get full text
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