Transporter Regulation in Critical Protective Barriers: Focus on Brain and Placenta

Drug transporters play an important role in the maintenance of chemical balance and homeostasis in different tissues. In addition to their physiological functions, they are crucial for the absorption, distribution, and elimination of many clinically important drugs, thereby impacting therapeutic eff...

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Veröffentlicht in:Pharmaceutics Jg. 14; H. 7; S. 1376
Hauptverfasser: Taggi, Valerio, Riera Romo, Mario, Piquette-Miller, Micheline, Meyer zu Schwabedissen, Henriette E., Neuhoff, Sibylle
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Basel MDPI AG 29.06.2022
MDPI
Schlagworte:
ABC
Brain
diseases
drug transporters
Fetuses
Immunology
Localization
Mass spectrometry
Permeability
Physiology
Placenta
Proteins
regulation
Review
Scientific imaging
SLC
ISSN:1999-4923, 1999-4923
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Zusammenfassung:Drug transporters play an important role in the maintenance of chemical balance and homeostasis in different tissues. In addition to their physiological functions, they are crucial for the absorption, distribution, and elimination of many clinically important drugs, thereby impacting therapeutic efficacy and toxicity. Increasing evidence has demonstrated that infectious, metabolic, inflammatory, and neurodegenerative diseases alter the expression and function of drug transporters. However, the current knowledge on transporter regulation in critical protective barriers, such as the brain and placenta, is still limited and requires more research. For instance, while many studies have examined P-glycoprotein, it is evident that research on the regulation of highly expressed transporters in the blood–brain barrier and blood–placental barrier are lacking. The aim of this review is to summarize the currently available literature in order to better understand transporter regulation in these critical barriers.
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These authors contributed equally to this work.
ISSN:1999-4923
1999-4923
DOI:10.3390/pharmaceutics14071376