Autophagy in cancer associated fibroblasts promotes tumor cell survival Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment

Recently, using a co-culture system, we demonstrated that MCF7 epithelial cancer cells induce oxidative stress in adjacent cancer-associated fibroblasts, resulting in the autophagic/lysosomal degradation of stromal caveolin-1 (Cav-1). However, the detailed signaling mechanism(s) underlying this proc...

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Vol. 9; no. 17; pp. 3515 - 3533
Main Authors:	Martinez-Outschoorn, Ubaldo E., Trimmer, Casey, Lin, Zhao, Whitaker-Menezes, Diana, Chiavarina, Barbara, Zhou, Jie, Wang, Chenguang, Pavlides, Stephanos, Martinez-Cantarin, Maria P., Capozza, Franco, Witkiewicz, Agnieszka K., Flomenberg, Neal, Howell, Anthony, Pestell, Richard G., Caro, Jaime, Lisanti, Michael P., Sotgia, Federica
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 01.09.2010 Landes Bioscience
Subjects:	Animals Antirheumatic Agents - pharmacology Apoptosis Regulatory Proteins Autophagy Binding Biology Bioscience Breast Neoplasms - metabolism Breast Neoplasms - pathology Calcium Cancer Caveolin 1 - genetics Caveolin 1 - metabolism Cell Cell Hypoxia Cell Line, Tumor Cell Survival Chloroquine - pharmacology Coculture Techniques Cycle Female Fibroblasts - metabolism Glutathione Synthase - antagonists & inhibitors Glutathione Synthase - metabolism Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Intracellular Signaling Peptides and Proteins - metabolism Landes Membrane Proteins - metabolism Mice Mice, Knockout Microtubule-Associated Proteins - metabolism NF-kappa B - metabolism Organogenesis Oxidative Stress Paracrine Communication Proteins Proto-Oncogene Proteins - metabolism RNA Interference RNA, Small Interfering - metabolism Stromal Cells - metabolism Tumor Microenvironment Tumor Suppressor Proteins - metabolism Up-Regulation
ISSN:	1538-4101, 1551-4005, 1551-4005
Online Access:	Get full text
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