Oncogenes induce the cancer-associated fibroblast phenotype: Metabolic symbiosis and "fibroblast addiction" are new therapeutic targets for drug discovery

Metabolic coupling, between mitochondria in cancer cells and catabolism in stromal fibroblasts, promotes tumor growth, recurrence, metastasis, and predicts anticancer drug resistance. Catabolic fibroblasts donate the necessary fuels (such as L-lactate, ketones, glutamine, other amino acids, and fatt...

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Vol. 12; no. 17; pp. 2723 - 2732
Main Authors:	Lisanti, Michael P., Martinez-Outschoorn, Ubaldo E., Sotgia, Federica
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 01.09.2013 Landes Bioscience
Subjects:	BRCA1 cancer-associated fibroblast Drug Discovery Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology glycolysis Humans metabolic symbiosis Molecular Targeted Therapy Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology NFkB oncogene Oncogenes - genetics oxidative stress Phenotype RAS stromal biomarkers TGF-beta tumor microenvironment tumor suppressor cancer-associated fibroblast TGF-beta RAS glycolysis tumor suppressor BRCA1 NFkB stromal biomarkers tumor microenvironment oncogene metabolic symbiosis oxidative stress
ISSN:	1538-4101, 1551-4005, 1551-4005
Online Access:	Get full text
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