Immunological Mechanisms Responsible for Radiation-Induced Abscopal Effect

Radiotherapy has been used for more than a hundred years as a local tumor treatment. The occurrence of systemic antitumor effects manifesting as regression of tumors outside of the irradiated field (abscopal effect) was occasionally observed but deemed too rare and unpredictable to be a therapeutic...

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Vydáno v:	Trends in immunology Ročník 39; číslo 8; s. 644 - 655
Hlavní autoři:	Rodríguez-Ruiz, María E., Vanpouille-Box, Claire, Melero, Ignacio, Formenti, Silvia Chiara, Demaria, Sandra
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Elsevier Ltd 01.08.2018 Elsevier Limited
Témata:	abscopal effect Animals Antitumor activity antitumor immunity Apoptosis Breast cancer Cancer Cancer therapies Combined Modality Therapy Deoxyribonucleic acid DNA DNA damage Humans Immune checkpoint Immune system Immunology Immunotherapy Immunotherapy - methods ionizing radiation Kinases Lymphocyte Activation Lymphocytes Lymphocytes T Mutation Neoplasm Metastasis Neoplasms - radiotherapy Proteins Radiation therapy Radiotherapy - methods T-Lymphocytes - immunology Tumor Burden tumor microenvironment Tumors abscopal effect tumor microenvironment antitumor immunity DNA damage ionizing radiation immunotherapy
ISSN:	1471-4906, 1471-4981, 1471-4981
On-line přístup:	Získat plný text
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