Risk factors for severe and critically ill COVID‐19 patients: A review

The pandemic of coronavirus disease 2019 (COVID‐19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused an unprecedented global social and economic impact, and high numbers of deaths. Many risk factors have been identified in the progression of COVID‐19 into a sev...

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Vydáno v:Allergy (Copenhagen) Ročník 76; číslo 2; s. 428 - 455
Hlavní autoři: Gao, Ya‐dong, Ding, Mei, Dong, Xiang, Zhang, Jin‐jin, Kursat Azkur, Ahmet, Azkur, Dilek, Gan, Hui, Sun, Yuan‐li, Fu, Wei, Li, Wei, Liang, Hui‐ling, Cao, Yi‐yuan, Yan, Qi, Cao, Can, Gao, Hong‐yu, Brüggen, Marie‐Charlotte, Veen, Willem, Sokolowska, Milena, Akdis, Mübeccel, Akdis, Cezmi A.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Denmark Blackwell Publishing Ltd 01.02.2021
Témata:
Computed tomography
Coronary artery disease
Coronaviridae
Coronaviruses
COVID-19
Critical Illness
Cytokine storm
Diabetes mellitus
Disease
Disease Progression
Eosinopenia
Female
Ferritin
Heart diseases
Humans
Inflammation
Interferon
Kidney diseases
L-Lactate dehydrogenase
Laboratories
Lactic acid
Liver diseases
Lung diseases
Lymphopenia
Male
Pandemics
Pregnancy complications
Procalcitonin
Risk Factors
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
severity
Tumors
COVID-19
severity
SARS-CoV-2
risk factors
critical illness
ISSN:0105-4538, 1398-9995, 1398-9995
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Popis
Shrnutí:The pandemic of coronavirus disease 2019 (COVID‐19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused an unprecedented global social and economic impact, and high numbers of deaths. Many risk factors have been identified in the progression of COVID‐19 into a severe and critical stage, including old age, male gender, underlying comorbidities such as hypertension, diabetes, obesity, chronic lung diseases, heart, liver and kidney diseases, tumors, clinically apparent immunodeficiencies, local immunodeficiencies, such as early type I interferon secretion capacity, and pregnancy. Possible complications include acute kidney injury, coagulation disorders, thoromboembolism. The development of lymphopenia and eosinopenia are laboratory indicators of COVID‐19. Laboratory parameters to monitor disease progression include lactate dehydrogenase, procalcitonin, high‐sensitivity C‐reactive protein, proinflammatory cytokines such as interleukin (IL)‐6, IL‐1β, Krebs von den Lungen‐6 (KL‐6), and ferritin. The development of a cytokine storm and extensive chest computed tomography imaging patterns are indicators of a severe disease. In addition, socioeconomic status, diet, lifestyle, geographical differences, ethnicity, exposed viral load, day of initiation of treatment, and quality of health care have been reported to influence individual outcomes. In this review, we highlight the scientific evidence on the risk factors of severity of COVID‐19.
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ISSN:0105-4538
1398-9995
1398-9995
DOI:10.1111/all.14657