Physical Activity, Brain Volume, and Dementia Risk: The Framingham Study

Several longitudinal studies found an inverse relationship between levels of physical activity and cognitive decline, dementia, and/or Alzheimer's disease (AD), but results have been inconsistent. We followed an older, community-based cohort for over a decade to examine the association of physi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The journals of gerontology. Series A, Biological sciences and medical sciences Jg. 72; H. 6; S. 789
Hauptverfasser: Tan, Zaldy S, Spartano, Nicole L, Beiser, Alexa S, DeCarli, Charles, Auerbach, Sanford H, Vasan, Ramachandran S, Seshadri, Sudha
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.06.2017
Schlagworte:
Age Factors
Aged
Alleles
Alzheimer Disease - epidemiology
Apolipoprotein E4 - genetics
Brain - diagnostic imaging
Cohort Studies
Dementia - epidemiology
Exercise
Female
Humans
Longitudinal Studies
Magnetic Resonance Imaging
Male
Risk
United States - epidemiology
Neuroimaging
Physical activity
Epidemiology
Alzheimer’s
Neurological disorders
ISSN:1758-535X, 1758-535X
Online-Zugang:Weitere Angaben
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Several longitudinal studies found an inverse relationship between levels of physical activity and cognitive decline, dementia, and/or Alzheimer's disease (AD), but results have been inconsistent. We followed an older, community-based cohort for over a decade to examine the association of physical activity with the risk of incident dementia and subclinical brain MRI markers of dementia. The physical activity index (PAI) was assessed in the Framingham Study Original and Offspring cohorts, aged 60 years or older. We examined the association between PAI and risk of incident all-cause dementia and AD in participants of both cohorts who were cognitively intact and had available PAI (n = 3,714; 54% women; mean age = 70±7 years). We additionally examined the association between PAI and brain MRI in the Offspring cohort (n = 1,987). Over a decade of follow-up, 236 participants developed dementia (188 AD). Participants in the lowest quintile of PAI had an increased risk of incident dementia compared with those in higher quintiles (hazard ratio [HR] = 1.50, 95% confidence interval [CI] = 1.04-1.97, p = .028) in a multivariable-adjusted model. Secondary analysis revealed that this relation was limited to participants who were apolipoprotein (APO)E ε4 allele noncarriers (HR = 1.58, 95% CI = 1.08-2.32; p = .018) and strongest in participants aged 75 years or older. PAI was also linearly related to total brain and hippocampal volumes (β ± SE = 0.24±0.06; p < .01 and 0.004±0.001; p = .003, respectively). Low physical activity is associated with a higher risk for dementia in older individuals, suggesting that a reduced risk of dementia and higher brain volumes may be additional health benefits of maintaining physical activity into old age.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1758-535X
1758-535X
DOI:10.1093/gerona/glw130