Muscle Quality and Muscle Fat Infiltration in Relation to Incident Mobility Disability and Gait Speed Decline: the Age, Gene/Environment Susceptibility-Reykjavik Study

Aging is associated with increased risk of reduced mobility. However, data on muscle components in relation to subjective and objective indicators of disability is limited. Data were from 2,725 participants (43% men) aged 74.8±4.7 years from the AGES-Reykjavik Study. At baseline, maximal isometric t...

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Vydáno v:	The journals of gerontology. Series A, Biological sciences and medical sciences Ročník 70; číslo 8; s. 1030
Hlavní autoři:	Reinders, Ilse, Murphy, Rachel A, Koster, Annemarie, Brouwer, Ingeborg A, Visser, Marjolein, Garcia, Melissa E, Launer, Lenore J, Siggeirsdottir, Kristin, Eiriksdottir, Gudny, Jonsson, Palmi V, Gudnason, Vilmundur, Harris, Tamara B
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.08.2015
Témata:	Adipose Tissue - metabolism Aged Aging - physiology Female Gait - physiology Gene-Environment Interaction Humans Male Mobility Limitation Muscle Strength Muscle, Skeletal - metabolism Muscle Gait Epidemiology Imaging Functional performance
ISSN:	1758-535X, 1758-535X
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Abstract	Aging is associated with increased risk of reduced mobility. However, data on muscle components in relation to subjective and objective indicators of disability is limited. Data were from 2,725 participants (43% men) aged 74.8±4.7 years from the AGES-Reykjavik Study. At baseline, maximal isometric thigh strength (dynamometer chair), and midthigh muscle area and muscle fat infiltration were assessed with computed tomography. Usual 6 m gait speed and mobility disability were assessed at baseline and after 5.2±0.3 years. Incident mobility disability was defined as having much difficulty or unable to walk 500 m or climb-up 10 steps. A decrease of ≥0.1 m/s in gait speed was considered clinically relevant. Greater strength and area were protective for mobility disability risk and gait speed decline. After adjustment for other muscle components, greater strength was independently associated with lower mobility disability risk in women odds ratios (OR) 0.78 (95% CI 0.62, 0.99), and lower decline in gait speed risk among both men OR 0.64 (0.54, 0.76), and women OR 0.72 (0.62, 0.82). Larger muscle area was independently associated with lower mobility disability risk in women OR 0.67 (0.52, 0.87) and lower decline in gait speed risk in men OR 0.74 (0.61, 0.91). Greater muscle strength and area were independently associated with 15-30% decreased risk of mobility disability in women and gait speed decline in men. Among women, greater muscle strength was also associated with lower risk of gait speed decline. Interventions aimed at maintaining muscle strength and area in old age might delay functional decline.
AbstractList	Aging is associated with increased risk of reduced mobility. However, data on muscle components in relation to subjective and objective indicators of disability is limited.BACKGROUNDAging is associated with increased risk of reduced mobility. However, data on muscle components in relation to subjective and objective indicators of disability is limited.Data were from 2,725 participants (43% men) aged 74.8±4.7 years from the AGES-Reykjavik Study. At baseline, maximal isometric thigh strength (dynamometer chair), and midthigh muscle area and muscle fat infiltration were assessed with computed tomography. Usual 6 m gait speed and mobility disability were assessed at baseline and after 5.2±0.3 years. Incident mobility disability was defined as having much difficulty or unable to walk 500 m or climb-up 10 steps. A decrease of ≥0.1 m/s in gait speed was considered clinically relevant.METHODSData were from 2,725 participants (43% men) aged 74.8±4.7 years from the AGES-Reykjavik Study. At baseline, maximal isometric thigh strength (dynamometer chair), and midthigh muscle area and muscle fat infiltration were assessed with computed tomography. Usual 6 m gait speed and mobility disability were assessed at baseline and after 5.2±0.3 years. Incident mobility disability was defined as having much difficulty or unable to walk 500 m or climb-up 10 steps. A decrease of ≥0.1 m/s in gait speed was considered clinically relevant.Greater strength and area were protective for mobility disability risk and gait speed decline. After adjustment for other muscle components, greater strength was independently associated with lower mobility disability risk in women odds ratios (OR) 0.78 (95% CI 0.62, 0.99), and lower decline in gait speed risk among both men OR 0.64 (0.54, 0.76), and women OR 0.72 (0.62, 0.82). Larger muscle area was independently associated with lower mobility disability risk in women OR 0.67 (0.52, 0.87) and lower decline in gait speed risk in men OR 0.74 (0.61, 0.91).RESULTSGreater strength and area were protective for mobility disability risk and gait speed decline. After adjustment for other muscle components, greater strength was independently associated with lower mobility disability risk in women odds ratios (OR) 0.78 (95% CI 0.62, 0.99), and lower decline in gait speed risk among both men OR 0.64 (0.54, 0.76), and women OR 0.72 (0.62, 0.82). Larger muscle area was independently associated with lower mobility disability risk in women OR 0.67 (0.52, 0.87) and lower decline in gait speed risk in men OR 0.74 (0.61, 0.91).Greater muscle strength and area were independently associated with 15-30% decreased risk of mobility disability in women and gait speed decline in men. Among women, greater muscle strength was also associated with lower risk of gait speed decline. Interventions aimed at maintaining muscle strength and area in old age might delay functional decline.CONCLUSIONSGreater muscle strength and area were independently associated with 15-30% decreased risk of mobility disability in women and gait speed decline in men. Among women, greater muscle strength was also associated with lower risk of gait speed decline. Interventions aimed at maintaining muscle strength and area in old age might delay functional decline. Aging is associated with increased risk of reduced mobility. However, data on muscle components in relation to subjective and objective indicators of disability is limited. Data were from 2,725 participants (43% men) aged 74.8±4.7 years from the AGES-Reykjavik Study. At baseline, maximal isometric thigh strength (dynamometer chair), and midthigh muscle area and muscle fat infiltration were assessed with computed tomography. Usual 6 m gait speed and mobility disability were assessed at baseline and after 5.2±0.3 years. Incident mobility disability was defined as having much difficulty or unable to walk 500 m or climb-up 10 steps. A decrease of ≥0.1 m/s in gait speed was considered clinically relevant. Greater strength and area were protective for mobility disability risk and gait speed decline. After adjustment for other muscle components, greater strength was independently associated with lower mobility disability risk in women odds ratios (OR) 0.78 (95% CI 0.62, 0.99), and lower decline in gait speed risk among both men OR 0.64 (0.54, 0.76), and women OR 0.72 (0.62, 0.82). Larger muscle area was independently associated with lower mobility disability risk in women OR 0.67 (0.52, 0.87) and lower decline in gait speed risk in men OR 0.74 (0.61, 0.91). Greater muscle strength and area were independently associated with 15-30% decreased risk of mobility disability in women and gait speed decline in men. Among women, greater muscle strength was also associated with lower risk of gait speed decline. Interventions aimed at maintaining muscle strength and area in old age might delay functional decline.
Author	Garcia, Melissa E Jonsson, Palmi V Harris, Tamara B Visser, Marjolein Murphy, Rachel A Koster, Annemarie Siggeirsdottir, Kristin Eiriksdottir, Gudny Reinders, Ilse Brouwer, Ingeborg A Launer, Lenore J Gudnason, Vilmundur
Author_xml	– sequence: 1 givenname: Ilse surname: Reinders fullname: Reinders, Ilse email: ilse.reinders@nih.gov organization: Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland. Department of Health Sciences and the EMGO Institute for Health and Care Research, Faculty of Earth and Life Sciences, VU University Amsterdam, The Netherlands. ilse.reinders@nih.gov – sequence: 2 givenname: Rachel A surname: Murphy fullname: Murphy, Rachel A organization: Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland – sequence: 3 givenname: Annemarie surname: Koster fullname: Koster, Annemarie organization: Department of Social Medicine, School for Public Health and Primary Care (CAPHRI), Maastricht University, Maastricht, The Netherlands – sequence: 4 givenname: Ingeborg A surname: Brouwer fullname: Brouwer, Ingeborg A organization: Department of Health Sciences and the EMGO Institute for Health and Care Research, Faculty of Earth and Life Sciences, VU University Amsterdam, The Netherlands – sequence: 5 givenname: Marjolein surname: Visser fullname: Visser, Marjolein organization: Department of Health Sciences and the EMGO Institute for Health and Care Research, Faculty of Earth and Life Sciences, VU University Amsterdam, The Netherlands. Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands – sequence: 6 givenname: Melissa E surname: Garcia fullname: Garcia, Melissa E organization: Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland – sequence: 7 givenname: Lenore J surname: Launer fullname: Launer, Lenore J organization: Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland – sequence: 8 givenname: Kristin surname: Siggeirsdottir fullname: Siggeirsdottir, Kristin organization: Icelandic Heart Association Research Institute, Kopavogur, Iceland – sequence: 9 givenname: Gudny surname: Eiriksdottir fullname: Eiriksdottir, Gudny organization: Icelandic Heart Association Research Institute, Kopavogur, Iceland – sequence: 10 givenname: Palmi V surname: Jonsson fullname: Jonsson, Palmi V organization: Department of Geriatrics, Landspitali National University Hospital and Faculty of Medicine, University of Iceland, Reykjavik, Iceland – sequence: 11 givenname: Vilmundur surname: Gudnason fullname: Gudnason, Vilmundur organization: Icelandic Heart Association Research Institute, Kopavogur, Iceland. Faculty of Medicine, University of Iceland, Reykjavik, Iceland – sequence: 12 givenname: Tamara B surname: Harris fullname: Harris, Tamara B organization: Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Bethesda, Maryland
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SubjectTerms	Adipose Tissue - metabolism Aged Aging - physiology Female Gait - physiology Gene-Environment Interaction Humans Male Mobility Limitation Muscle Strength Muscle, Skeletal - metabolism
Title	Muscle Quality and Muscle Fat Infiltration in Relation to Incident Mobility Disability and Gait Speed Decline: the Age, Gene/Environment Susceptibility-Reykjavik Study
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