The miRNome of Depression

Depression is an effect of complex interactions between genetic, epigenetic and environmental factors. It is well established that stress responses are associated with multiple modest and often dynamic molecular changes in the homeostatic balance, rather than with a single genetic factor that has a...

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Vydáno v:International journal of molecular sciences Ročník 22; číslo 21; s. 11312
Hlavní autoři: Żurawek, Dariusz, Turecki, Gustavo
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 20.10.2021
MDPI
Témata:
Animals
Antidepressants
Biological Evolution
Biomarkers
Biosynthesis
Brain research
Depression - genetics
Depressive Disorder, Major - genetics
Drugs
Enzymes
Epigenesis, Genetic - genetics
Epigenetics
Gene expression
Gene Expression - genetics
Gene Expression Profiling - methods
Gene Expression Regulation - genetics
Genomes
Humans
Mammals
Mental depression
MicroRNAs
MicroRNAs - genetics
Multifactorial Inheritance - genetics
Proteins
Review
RNA Interference - physiology
Transcriptome - genetics
antidepressant treatment
microRNA
human brain
miRNome
depression
biomarker
ISSN:1422-0067, 1661-6596, 1422-0067
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Shrnutí:Depression is an effect of complex interactions between genetic, epigenetic and environmental factors. It is well established that stress responses are associated with multiple modest and often dynamic molecular changes in the homeostatic balance, rather than with a single genetic factor that has a strong phenotypic penetration. As depression is a multifaceted phenotype, it is important to study biochemical pathways that can regulate the overall allostasis of the brain. One such biological system that has the potential to fine-tune a multitude of diverse molecular processes is RNA interference (RNAi). RNAi is an epigenetic process showing a very low level of evolutionary diversity, and relies on the posttranscriptional regulation of gene expression using, in the case of mammals, primarily short (17–23 nucleotides) noncoding RNA transcripts called microRNAs (miRNA). In this review, our objective was to examine, summarize and discuss recent advances in the field of biomedical and clinical research on the role of miRNA-mediated regulation of gene expression in the development of depression. We focused on studies investigating post-mortem brain tissue of individuals with depression, as well as research aiming to elucidate the biomarker potential of miRNAs in depression and antidepressant response.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms222111312