A Role for ER-Beta in the Effects of Low-Density Lipoprotein Cholesterol and 27-Hydroxycholesterol on Breast Cancer Progression: Involvement of the IGF Signalling Pathway?

Cholesterol—in particular, high levels of low-density lipoprotein (LDL) and its metabolite, 27-hydroxycholesterol (27-OHC)—is correlated with increases in the risks of breast cancer and obesity. Although the high expression of LDL/27-OHC has been reported in breast cancer, its effects and mechanism...

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Bibliographic Details
Published in:	Cells (Basel, Switzerland) Vol. 11; no. 1; p. 94
Main Authors:	Mashat, Reham M., Zielinska, Hanna A., Holly, Jeff M. P., Perks, Claire M.
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 29.12.2021 MDPI
Subjects:	27-OHC Biomarkers, Tumor - metabolism Breast cancer Breast carcinoma Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell adhesion & migration Cell growth Cell Line, Tumor Cell migration Cell Movement Cell Proliferation Cholesterol Cholesterol, LDL - metabolism Cytochrome Cytochrome P450 Disease Progression Epidermal growth factor Epithelial-Mesenchymal Transition ErbB Receptors - metabolism Estrogen Receptor beta - agonists Estrogen Receptor beta - antagonists & inhibitors Estrogen Receptor beta - metabolism Female Gene expression Humans Hydroxycholesterols - metabolism Hydroxylase IGF-I Insulin Insulin-like growth factor I Insulin-Like Growth Factor I - metabolism Insulin-like growth factors Invasiveness Kinases Lipoproteins Low density lipoprotein Medical research Metabolism Metabolites Metabolome Mortality Neoplasm Invasiveness oestrogen receptor-beta Proteins Receptor, IGF Type 1 Signal Transduction Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology Tumors Chicago Illinois St Louis Missouri United Kingdom > UK United States > US oestrogen receptor-beta breast cancer IGF-I 27-OHC
ISSN:	2073-4409, 2073-4409
Online Access:	Get full text
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