Implications of reactive oxygen species on cancer formation and its treatment

Elevated levels of reactive oxygen species (ROS) are a hallmark of cancer. Although increased ROS concentrations play important roles in cancer formation and progression, levels above a cytotoxic threshold cause cancer cell death. Cancer cells adapt to high concentrations of ROS via antioxidant prod...

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Vydáno v:Seminars in oncology Ročník 48; číslo 3; s. 238
Hlavní autoři: Shah, Manish A, Rogoff, Harry A
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.06.2021
Témata:
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Humans
Neoplasms - drug therapy
Neoplasms - pathology
Oxidative Stress
Reactive Oxygen Species - metabolism
Reactive Oxygen Species - pharmacology
Reactive Oxygen Species - therapeutic use
treatment
cancer
drug resistance
reduction-oxidation balance
reactive oxygen species
ISSN:1532-8708, 1532-8708
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Shrnutí:Elevated levels of reactive oxygen species (ROS) are a hallmark of cancer. Although increased ROS concentrations play important roles in cancer formation and progression, levels above a cytotoxic threshold cause cancer cell death. Cancer cells adapt to high concentrations of ROS via antioxidant production and reprogrammed cellular metabolism (eg, the Warburg effect). Because some widely used anticancer therapies such as radiation therapy and chemotherapy rely on ROS accumulation as a mechanism to induce cancer cell death, a cancer cell's ability to control ROS levels is a driver of treatment resistance and a critical consideration for successful cancer treatment. The necessity for cancer cells to adapt to elevated levels of ROS to survive may represent an Achilles heel for some malignancies, as therapies designed to interfere with this adaptation would be expected to kill cancer cells. In this review, we provide an overview of the implications of ROS on cancer formation and anticancer treatment strategies, with a focus on treatment-resistant disease.
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SourceType-Scholarly Journals-1
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ISSN:1532-8708
1532-8708
DOI:10.1053/j.seminoncol.2021.05.002