Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

Replication fork reversal protects forks from breakage after poisoning of Topoisomerase 1. We here investigated fork progression and chromosomal breakage in human cells in response to a panel of sublethal genotoxic treatments, using other topoisomerase poisons, DNA synthesis inhibitors, interstrand...

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Vydané v:	The Journal of cell biology Ročník 208; číslo 5; s. 563
Hlavní autori:	Zellweger, Ralph, Dalcher, Damian, Mutreja, Karun, Berti, Matteo, Schmid, Jonas A, Herrador, Raquel, Vindigni, Alessandro, Lopes, Massimo
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 02.03.2015
Predmet:	Cell Line, Tumor DNA Damage DNA Replication HEK293 Cells Humans Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Rad51 Recombinase - metabolism RecQ Helicases - genetics RecQ Helicases - metabolism Topoisomerase Inhibitors - toxicity
ISSN:	1540-8140, 1540-8140
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