How do real tumors become resistant to cisplatin?

Lab research on cultured tumor cells selected for resistance to platinum compounds has turned up a diverse array of resistance mechanisms. In contrast, we recently found that mouse mammary tumors containing irrepairable null alleles of the Brca1 gene do not become resistant to cisplatin ever, althou...

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Vol. 7; no. 10; pp. 1353 - 1359
Main Authors:	Borst, Piet, Rottenberg, Sven, Jonkers, Jos
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 15.05.2008
Subjects:	Animals Antineoplastic Agents - toxicity Binding Biology Bioscience Breast Neoplasms - drug therapy Breast Neoplasms - genetics Calcium Cancer Cell Cisplatin - toxicity Cycle DNA Repair - genetics Drug Resistance, Neoplasm - genetics Genes, BRCA1 Landes Maximum Tolerated Dose Mice Mutation - genetics Organogenesis Proteins Tumor Cells, Cultured
ISSN:	1538-4101, 1551-4005, 1551-4005
Online Access:	Get full text
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