Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

Oncogene-induced DNA replication stress activates the DNA damage response (DDR), a crucial anticancer barrier. DDR inactivation in these conditions promotes genome instability and tumor progression, but the underlying molecular mechanisms are elusive. We found that overexpression of both Cyclin E an...

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Vydané v:	The Journal of cell biology Ročník 200; číslo 6; s. 699
Hlavní autori:	Neelsen, Kai J, Zanini, Isabella M Y, Herrador, Raquel, Lopes, Massimo
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 18.03.2013
Predmet:	CDC2 Protein Kinase - genetics CDC2 Protein Kinase - metabolism cdc25 Phosphatases - genetics cdc25 Phosphatases - metabolism Cell Line, Tumor Chromosome Breakage Cyclin E - genetics Cyclin E - metabolism DNA Replication DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endonucleases - genetics Endonucleases - metabolism G2 Phase Humans Mitosis Oncogenes
ISSN:	1540-8140, 1540-8140
On-line prístup:	Zistit podrobnosti o prístupe
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