Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

Oncogene-induced DNA replication stress activates the DNA damage response (DDR), a crucial anticancer barrier. DDR inactivation in these conditions promotes genome instability and tumor progression, but the underlying molecular mechanisms are elusive. We found that overexpression of both Cyclin E an...

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Bibliographic Details
Published in:	The Journal of cell biology Vol. 200; no. 6; p. 699
Main Authors:	Neelsen, Kai J, Zanini, Isabella M Y, Herrador, Raquel, Lopes, Massimo
Format:	Journal Article
Language:	English
Published:	United States 18.03.2013
Subjects:	CDC2 Protein Kinase - genetics CDC2 Protein Kinase - metabolism cdc25 Phosphatases - genetics cdc25 Phosphatases - metabolism Cell Line, Tumor Chromosome Breakage Cyclin E - genetics Cyclin E - metabolism DNA Replication DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endonucleases - genetics Endonucleases - metabolism G2 Phase Humans Mitosis Oncogenes
ISSN:	1540-8140, 1540-8140
Online Access:	Get more information
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