The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies

Atopic dermatitis (AD), the most common chronic inflammatory skin disease, is driven by both terminal keratinocyte differentiation defects and strong type 2 immune responses. In contrast to chronic plaque-type psoriasis, AD is now understood to be a much more heterogeneous disease, with additional a...

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Vydáno v:	Journal of allergy and clinical immunology Ročník 139; číslo 4; s. S65 - S76
Hlavní autoři:	Brunner, Patrick M., Guttman-Yassky, Emma, Leung, Donald Y.M.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Elsevier Inc 01.04.2017 Elsevier Limited
Témata:	Accreditation Allergies Allergy and Immunology Animals Anti-Inflammatory Agents - therapeutic use Atopic dermatitis Chronic illnesses Copyright Cytokines Cytokines - metabolism Dermatitis Dermatitis, Atopic - immunology Dermatitis, Atopic - therapy Eczema Health education Human subjects Humans immune Immune response Immunology Inflammation keratinocyte Keratinocytes - physiology Kinases Light therapy Molecular Targeted Therapy Pathogenesis Pharmaceutical industry Psoriasis Skin Skin diseases skin immune map Studies targeted therapy Th17 Cells - immunology Th2 Cells - immunology T helper cell FLG targeted therapy immune AD AMP TSLP OX40L PDE T helper cell EASI Atopic dermatitis keratinocyte JAK eczema CRTH2 skin immune map Prostaglandin DP2 receptor Eczema Area and Severity Index Filaggrin OX40 ligand Thymic stromal lymphopoietin Janus kinase Antimicrobial peptide Phosphodiesterase
ISSN:	0091-6749, 1097-6825, 1097-6825
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