A noncatalytic function of the ligation complex during nonhomologous end joining

Nonhomologous end joining is the primary deoxyribonucleic acid (DNA) double-strand break repair pathway in multicellular eukaryotes. To initiate repair, Ku binds DNA ends and recruits the DNA-dependent protein kinase (DNA-PK) catalytic subunit (DNA-PKcs) forming the holoenzyme. Early end synapsis is...

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Veröffentlicht in:	The Journal of cell biology Jg. 200; H. 2; S. 173
Hauptverfasser:	Cottarel, Jessica, Frit, Philippe, Bombarde, Oriane, Salles, Bernard, Négrel, Aurélie, Bernard, Stéphanie, Jeggo, Penny A, Lieber, Michael R, Modesti, Mauro, Calsou, Patrick
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 21.01.2013
Schlagworte:	Cell-Free System - metabolism Cells, Cultured DNA Damage DNA End-Joining Repair - physiology DNA Helicases - metabolism DNA Helicases - physiology DNA Ligase ATP DNA Ligases - metabolism DNA Ligases - physiology DNA Repair Enzymes - metabolism DNA Repair Enzymes - physiology DNA-Activated Protein Kinase - metabolism DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Genomic Instability Holoenzymes Humans Ku Autoantigen Phosphorylation
ISSN:	1540-8140, 1540-8140
Online-Zugang:	Weitere Angaben
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