Use of the Open Field Maze to Measure Locomotor and Anxiety-like Behavior in Mice

Animal models have proven to be invaluable to researchers trying to answer questions regarding the mechanisms of behavior. The Open Field Maze is one of the most commonly used platforms to measure behaviors in animal models. It is a fast and relatively easy test that provides a variety of behavioral...

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Vydáno v:Journal of visualized experiments číslo 96; s. e52434
Hlavní autoři: Seibenhener, Michael L., Wooten, Michael C.
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States MyJove Corporation 06.02.2015
Témata:
animal models
Animals
anxiety
Anxiety - physiopathology
Anxiety - psychology
Behavior
Behavior, Animal - physiology
Locomotion - physiology
Maze Learning
Mice
Mice, Inbred C57BL
Mice, Knockout
rats
tranquilizers
ISSN:1940-087X, 1940-087X
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Shrnutí:Animal models have proven to be invaluable to researchers trying to answer questions regarding the mechanisms of behavior. The Open Field Maze is one of the most commonly used platforms to measure behaviors in animal models. It is a fast and relatively easy test that provides a variety of behavioral information ranging from general ambulatory ability to data regarding the emotionality of the subject animal. As it relates to rodent models, the procedure allows the study of different strains of mice or rats both laboratory bred and wild-captured. The technique also readily lends itself to the investigation of different pharmacological compounds for anxiolytic or anxiogenic effects. Here, a protocol for use of the open field maze to describe mouse behaviors is detailed and a simple analysis of general locomotor ability and anxiety-related emotional behaviors between two strains of C57BL/6 mice is performed. Briefly, using the described protocol we show Wild Type mice exhibited significantly less anxiety related behaviors than did age-matched Knock Out mice while both strains exhibited similar ambulatory ability.
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Correspondence to: Michael L. Seibenhener at SEIBEMI@auburn.edu
ISSN:1940-087X
1940-087X
DOI:10.3791/52434