Cytochrome P450 Enzymes and Drug Metabolism in Humans

Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In humans, almost 80% of oxidative metabolism and approximately 50% of the overall elimination of common clinical drugs can be attributed to...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 22; no. 23; p. 12808
Main Authors:	Zhao, Mingzhe, Ma, Jingsong, Li, Mo, Zhang, Yingtian, Jiang, Bixuan, Zhao, Xianglong, Huai, Cong, Shen, Lu, Zhang, Na, He, Lin, Qin, Shengying
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 26.11.2021 MDPI
Subjects:	Animals Cancer therapies Clinical outcomes Cytochrome Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Drugs Enzymes Epigenetics Humans Inactivation, Metabolic Ligands Metabolic Clearance Rate Metabolism Metabolites Pharmaceutical Preparations - metabolism Pharmaceuticals Polymorphism, Genetic Review Xenobiotics - metabolism protein structure cytochrome P450 genetic polymorphisms drug metabolism
ISSN:	1422-0067, 1661-6596, 1422-0067
Online Access:	Get full text
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