Keeping Mammalian Mutation Load in Check: Regulation of the Activity of Error-Prone DNA Polymerases by p53 and p21

To overcome DNA lesions that block replication the cell employs translesion DNA synthesis (TLS) polymerases, a group of low fidelity DNA polymerases that have the capacity to bypass a wide range of DNA lesions. This TLS process is also termed error-prone repair, due to its inherent mutagenic nature....

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Vol. 5; no. 17; pp. 1918 - 1922
Main Author:	Livneh, Zvi
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 01.09.2006
Subjects:	Animals Binding Biology Bioscience Calcium Cancer Cell Cycle Cyclin-Dependent Kinase Inhibitor p21 - metabolism DNA - biosynthesis DNA Damage DNA Repair DNA-Directed DNA Polymerase - metabolism Landes Models, Genetic Mutation Organogenesis Proliferating Cell Nuclear Antigen - metabolism Proteins Tumor Suppressor Protein p53 - metabolism Ubiquitin - metabolism
ISSN:	1538-4101, 1551-4005, 1551-4005
Online Access:	Get full text
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